Anti-Cancer Light-Controllable Antibody-Peptide Conjugates

Project Information

ALISE

Grant agreement ID: 101007256

DOI

10.3030/101007256

EC signature date 19 October 2020

Start date 1 March 2021

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 745 200,00

EU contribution

€ 745 200,00

Coordinated by

ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE
Ukraine

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Deliverables

Documents, reports (6)

Mid-term meeting

Midterm meeting

Structures of the in silico-optimized novel light-controllable peptides

The structures of novel peptides formulae and the calculation results

Progress report 2
Web-site of the Project
Progress report 1
Manuscript of a paper describing new light-controllable peptides

Manuscript accepted for the publication in a peer-reviewed Journal

Publications

Peer reviewed articles (8)

Neural Network Models for Prediction of Biological Activity using Molecular Dynamics Data: A Case of Photoswitchable Peptides

Author(s): Anton Cherednichenko, Sergii Afonin, Oleg Babii, Taras Voitsitskyi, Roman Stratiichuk, Ihor Koleiev, Volodymyr Vozniak, Nazar Shevchuk, Zakhar Ostrovsky, Semen Yesylevskyy, Alan Nafiiev, Serhii Starosyla, Anne S. Ulrich, Aigars Jirgensons, Igor V. Komarov
Published in: Molecular Informatics, Issue 44, 2025, Page(s) e70001, ISSN 1868-1743
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/minf.70001

Highly Fluorinated Peptide Probes with Enhanced In Vivo Stability for 19F-MRI

Author(s): Beibei Meng, Stephan L. Grage, Oleg Babii, Masanari Takamiya, Neil MacKinnon, Tim Schober, Illia Hutskalov, Omar Nassar, Sergii Afonin, Serhii Koniev, Igor V. Komarov, Jan G. Korvink, Uwe Strähle, Anne S. Ulrich
Published in: Small, Issue 18 (41), 2022, Page(s) 2107308, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202107308

Insights into Modeling Approaches in Chemistry: Assessing Ligand-Protein Binding Thermodynamics Based on Rigid-Flexible Model Molecules

Author(s): Prof. Dr. Igor V. Komarov, Prof. Dr. Volodymyr A. Bugrov, Anton Cherednychenko, Dr. Oleksandr O. Grygorenko
Published in: The Chemical Record, Issue 24(2), 2023, Page(s) e202300276, ISSN 1527-8999
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/tcr.202300276

<i>In vitro</i> evaluation of the immunogenic potential of gramicidin S and its photocontrolled analogues

Author(s): Kateryna Horbatok, Iryna Semchuk, Oleksandr Horbach, Natalia Khranovska, Viktoriia Kosach, Petro Borysko, Serhii Koniev, Anne S. Ulrich, Sergii Afonin, Igor V. Komarov
Published in: RSC Medicinal Chemistry, Issue 12, 2025, ISSN 2632-8682
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5md00075k

Spiropyran‐Based Photoisomerizable α‐Amino Acid for Membrane‐Active Peptide Modification

Author(s): Andrii Hrebonkin, Sergii Afonin, Anna Nikitjuka, Oleksandr V. Borysov, Gundars Leitis, Oleg Babii, Serhii Koniev, Theo Lorig, Stephan L. Grage, Peter Nick, Anne S. Ulrich, Aigars Jirgensons, Igor V. Komarov
Published in: Chemistry – A European Journal, Issue 30, 2025, Page(s) e202400066, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202400066

Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution

Author(s): Mia Kapun, F. Javier Pérez-Areales, Nicola Ashman, Pamela J. E. Rowling, Tim Schober, Elaine Fowler, Laura S. Itzhaki, David R. Spring
Published in: RSC Chem. Biol., Issue 5, 2023, Page(s) 49-54, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cb00176h

Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules

Author(s): Thomas Wharton, Felicity Crawshay‐Williams, Tim Schober, R. Andres Floto, David R. Spring
Published in: Angewandte Chemie International Edition, Issue 63, 2024, Page(s) e202402267, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202402267

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

Author(s): Horbatok, Kateryna, Makhnii, Tetyana, Kosach, Viktoriia, Danko, Volodymyr, Kovalenko, Andrey, Fatiushchenkov, Stanislav,m Borysko, Petro, Pishel, Iryna, Babii, Oleg, Ulrich, Anne, Schober, Tim, Afonin, Sergii, Komarov, Igor V.
Published in: JoVE, Issue 199, 2023, Page(s) e64902, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/64902