Translational Research on Endometriosis

Deliverables

Platform to measure in vitro the effect of novel drugs on nerve fibre growth and pain

Report on establishment of a platform to measure in vitro the effect of novel drugs on nerve fibre growth and pain

Identification of new endometriosis targeting peptide candidates

Report on the identification of new endometriosis targeting peptide candidates

Establishment of a series of innovative in vitro models for studying endometriosis and for drug screening

Report on the establishment of a series of innovative in vitro models for studying endometriosis and for drug screening

Comparison of in vitro targeting performance of newly identified endometriosis binding peptides with existing peptides found in the literature

Report on the comparison of in vitro targeting performance of newly identified endometriosis binding peptides with existing peptides found in the literature

Website and Social media pages

Deocumentation of the establishment of a project website and Social media pages

Publications

Homing Peptide-Based Targeting of Tenascin-C and Fibronectin in Endometriosis

Author(s): Lorena Simón-Gracia, Kristina Kiisholts Vilma Petrikaitė, Allan Tobi, Merli Saare, Prakash Lingasamy , Maire Peters, Andres Salumets, Tambet Teesalu
Published in: Nanomaterials (Basel), Issue 11, 2021, Page(s) 3257, ISSN 2079-4991
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nano11123257

Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms

Author(s): Emond, Jean-Philippe; Caron, Patrick; Pušić Novak, Maja; Turcotte, Véronique; Simonyan, David; Vogler, Andrej; Osredkar, Joško; Lanišnik-Rižner, Tea; Guillemette, Chantal
Published in: Frontiers in endocrinology, Issue 13, 2021, Page(s) 1034614, ISSN 1664-2392
Publisher: Frontiers Media S.A.
DOI: 10.3389/fendo.2022.1034614

TGFBI as a candidate biomarker for non-invasive diagnosis of early-stage endometriosis

Author(s): Vid Janša, Maja Pušić Novak, Helena Ban Frangež, Tea Lanišnik Rižner
Published in: Human Reproduction, Issue 38, 2023, Page(s) 1284-1296, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/dead091

Antibody Arrays Identified Cycle-Dependent Plasma Biomarker Candidates of Peritoneal Endometriosis

Author(s): Maja Pušić , Teja Klančič, Tamara Knific, Andrej Vogler, Ronny Schmidt, Christoph Schröder, Tea Lanišnik Rižner
Published in: Journal of personalized medicine, 2022, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm12060852

Diagnostic delay of endometriosis in adults and adolescence-current stage of knowledge

Author(s): Monika Wróbel Mirosław Wielgoś, Piotr Laudański
Published in: Advances in Medical Sciences, Issue 67, 2022, Page(s) 148-153, ISSN 1896-1126
Publisher: Medical University of Bialystok
DOI: 10.1016/j.advms.2022.02.003

Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis

Author(s): Piotr Laudański, Gabriela Rogalska, Damian Warzecha, Michał Lipa, Grzegorz Mańka, Mariusz Kiecka, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Toomas Neuman, Priit Adler, Hedi Peterson, Andres Salumets, Miroslaw Wielgos
Published in: Human Reproduction, Issue 38, 2023, Page(s) 629-643, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/dead011

Users’ Concerns About Endometriosis on Social Media: Sentiment Analysis and Topic Modeling Study

Author(s): Rahul Goel; Vijayachitra Modhukur; Katrin Täär; Andres Salumets; Rajesh Sharma; Maire Peters
Published in: Journal of Medical Internet Research, Issue 25, 2023, Page(s) e45381, ISSN 1438-8871
Publisher: Journal of medical Internet Research
DOI: 10.2196/45381

Aging promotes accumulation of senescent and multiciliated cells in human endometrial epithelium

Author(s): Marina Loid, Darina Obukhova, Keiu Kask, Apostol Apostolov, Alvin Meltsov, Demis Tserpelis, Arthur van den Wijngaard, Signe Altmäe, Galina Yahubyan, Vesselin Baev, Merli Saare, Maire Peters, Ave Minajeva, Priit Adler, Ganesh Acharya, Kaarel Krjutškov, Maria Nikolova, Felipe Vilella, Carlos Simon, Masoud Zamani Esteki, Andres Salumets
Published in: Human Reproduction Open, Issue 2024, 2024, ISSN 2399-3529
Publisher: Oxford University Press
DOI: 10.1093/hropen/hoae048

Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis

Author(s): Barbara Lisowska-Myjak; Ewa Skarżyńska; Monika Wróbel; Grzegorz Mańka; Mariusz Kiecka; Michał Lipa; Damian Warzecha; Robert Spaczyński; Piotr Piekarski; Beata Banaszewska; Artur Jakimiuk; Tadeusz Issat; Wojciech Rokita; Jakub Młodawski; Maria Szubert; Piotr Sieroszewski; Grzegorz Raba; Kamil Szczupak; Tomasz Kluz; Marek Kluza; Mirosław Wielgoś; Piotr Laudański
Published in: International Joiurnal of Molecular Sciences, Issue 24, 2023, Page(s) 7828, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24097828

N-glycans from serum IgG and total serum glycoproteins specific for endometriosis

Author(s): Zsuzsanna Kovács, Fiona Reidy, Louise Glover, Fionnuala M. McAuliffe, Henning Stockmann, Mark T. Kilbane, Patrick J. Twomey, Maire Peters, Merli Saare, Pauline M. Rudd, Meeme Utt, Mary Wingfield, Andres Salumets, Radka Saldova
Published in: Scientific Reports, Issue 13, 2023, Page(s) 10480, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-37421-5

The cervical transcriptome changes during the menstrual cycle but does not predict the window of implantation

Author(s): Amruta D S Pathare, Merli Saare, Alvin Meltsov, Ankita Lawarde, Vijayachitra Modhukur, Aive Kalinina, Aire Sekavin, Viktorija Kukushkina, Helle Karro, Andres Salumets, Maire Peters
Published in: Frontiers in Reproductive Health, Issue 5, 2023, Page(s) 1224919, ISSN 2673-3153
Publisher: Frontiers Media SA
DOI: 10.3389/frph.2023.1224919

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Author(s): Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L. Møller, Lilja Stefansdottir, Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H. Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Błażej Marciniak, Margit Nõukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F. Topbas-
Published in: Nature Genetics, Issue 55, 2023, Page(s) 423–436, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01323-z

Evaluation of Proteasome and Immunoproteasome Levels in Plasma and Peritoneal Fluid in Patients with Endometriosis

Author(s): Monika Wróbel, Zielińska Zuzanna, Łukasz Ołdak, Aleksandra Kalicka, Grzegorz Mańka, Mariusz Kiecka, Robert Z. Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Piotr Pierzyński, Cezary Wojtyła, Michał Lipa, Damian Warzecha, Mirosław W
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 14363, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241814363

Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis

Author(s): Joanna Kacperczyk-Bartnik, Paweł Bartnik, Ksawery Goławski, Janusz Sierdziński, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Krzysztof Czajkowski, Mirosław Wielgo
Published in: Biomedicines, Issue 10, 2024, Page(s) 2451, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10102451

Plasma and Peritoneal Fluid ZEB Levels in Patients with Endometriosis and Infertility

Author(s): Paweł Bartnik; Joanna Kacperczyk-Bartnik; Ksawery Goławski; Janusz Sierdziński; Grzegorz Mańka; Mariusz Kiecka; Michał Lipa; Damian Warzecha; Robert Spaczyński; Piotr Piekarski; Beata Banaszewska; Artur J. Jakimiuk; Tadeusz Issat; Wojciech Rokita; Jakub Młodawski; Maria Szubert; Piotr Sieroszewski; Grzegorz Raba; Kamil Szczupak; Tomasz Kluz; Marek Kluza; Krzysztof Czajkowski; Mirosław Wiel
Published in: Biomedicines; Volume 10; Issue 10; Pages: 2460, Issue 2, 2022, Page(s) 2460, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10102460

Carboxypeptidase Inhibitor LXN Expression in Endometrial Tissue Is Menstrual Cycle Phase-Dependent and Is Upregulated in Endometriotic Lesions

Author(s): Meruert Sarsenova, Artjom Stepanjuk, Merli Saare, Sergo Kasvandik, Pille Soplepmann, Iveta Mikeltadze, Martin Götte, Andres Salumets, Maire Peters
Published in: Genes, Issue 15, 2024, Page(s) 1086, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes15081086

An Array SPRi Biosensor for the Determination on PARP-1 in Blood Plasma

Author(s): Zuzanna Zielinska, Lukasz Oldak, Joanna Kacperczyk-Bartnik, Ewa Koc-Żórawska, Marcin Żórawski, Piotr Laudanski, Ewa Gorodkiewicz
Published in: Biomedicines, Issue 11, 2023, Page(s) 602, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines11020602

Plasma and Peritoneal Fluid Annexin A2 Levels in Patients with Endometriosis

Author(s): Michal Zygarowicz, Joanna Kacperczyk-Bartnik, Janusz Sierdzinski, Cezary Wojtyla, Piotr Pierzynski, Grzegorz Manka, Mariusz Kiecka, Robert Z Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Michal Lipa, Damian Warzecha, Miroslaw Wielgos, Ewa Ko
Published in: Journal of Inflammation Research, Issue Volume 16, 2023, Page(s) 5959-5969, ISSN 1178-7031
Publisher: Dove Medical Press Ltd
DOI: 10.2147/jir.s421389

Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities

Author(s): M Peters, I Mikeltadze, H Karro, M Saare, Estonian Biobank Research Team , A Salumets, R Mägi, T Laisk
Published in: Human Reproduction, 2022, ISSN 0268-1161
Publisher: Oxford University Press
DOI: 10.1093/humrep/deac140

Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro

Author(s): Darja Lavogina, Nadja Visser, Külli Samuel, Eva Davey, Richelle D. Björvang, Jasmin Hassan, Jani Koponen, Panu Rantakokko, Hannu Kiviranta, Ago Rinken, Matts Olovsson, Andres Salumets, Pauliina Damdimopoulou
Published in: Frontiers in Endocrinology, Issue 13, 2022, ISSN 1664-2392
Publisher: Frontiers Media
DOI: 10.3389/fendo.2022.903505

Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis

Author(s): Damian Warzecha, Julia Załęcka, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Mirosław Wielgoś, Łukasz Ołdak, Anna Leśniewska, Ewa Gorodkiewicz, Piotr Laudański
Published in: International Journal of Molecular Sciences, Issue 23, 2024, Page(s) 15669, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415669

Assessment of the Ferroptosis Regulators: Glutathione Peroxidase 4, Acyl-Coenzyme A Synthetase Long-Chain Family Member 4, and Transferrin Receptor 1 in Patient-Derived Endometriosis Tissue

Author(s): Lidia A. Mielke Cabello, Gabriela Meresman, Dogus Darici, Noelia Carnovale, Birthe Heitkötter, Miriam Schulte, Nancy A. Espinoza-Sánchez, Quang-Khoi Le, Ludwig Kiesel, Sebastian D. Schäfer, Martin Götte
Published in: Biomolecules, Issue 14, 2024, Page(s) 876, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom14070876

The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among Patients with Endometriosis and Endometriosis-Related Infertility

Author(s): Ksawery Goławski, Robert Soczewica, Joanna Kacperczyk-Bartnik, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Mirosław Wielgoś, Ewa Koc-Żórawska, Marcin Żórawski,
Published in: International Journal of Environmental Research and Public Health, Issue 19, 2024, Page(s) 11586, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph191811586

Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis

Author(s): Theresa Strauß; Burkhard Greve; Michael Gabriel; Nurjannah Achmad; Dhanusha Schwan; Nancy Adriana Espinoza-Sanchez; Antonio Simone Laganà; Ludwig Kiesel; Matti Poutanen; Martin Götte; Sebastian Daniel Schäfer
Published in: International Journal of Molecular Sciences, Issue 23, 2022, Page(s) 2851, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23052851

Corrigendum to “Diagnostic delay of endometriosis in adults and adolescence-current stage of knowledge” [Adv. Med. Sci. (2022 Mar) 67 (1) 148-153]

Author(s): Monika Wróbel; Mirosław Wielgoś; Piotr Laudański
Published in: Advances in Medical Sciences, Issue 68, 2022, Page(s) 69, ISSN 1896-1126
Publisher: Medical University of Bialystok
DOI: 10.1016/j.advms.2022.12.004

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

Author(s): Ewa Skarżyńska, Monika Wróbel, Hanna Zborowska, Mateusz Franciszek Kołek, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Mirosław Wielgoś, Barbara Lisowska-Myjak,
Published in: International Journal of Molecular Sciences, Issue 24, 2024, Page(s) 1619, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24021619

Deliverables

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