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CORDIS

SUPporting high quality evaluation of COVID-19 convalescent Plasma thrOughoutT Europe

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

D3.4 Dashboard report (opens in new window)

Dashboard report

Final recommendations for CCP use to treat COVID-19 (opens in new window)
D2.7 Assessment report on data quality and number of complete datasets (opens in new window)

Assessment report on data quality and number of complete datasets

D7.1 Composition of the Scientific and Ethics Advisory Board (opens in new window)

Composition of the Scientific and Ethics Advisory Board.

D2.6 Status report: SUPPORT-E funding of clinical trials in need. (opens in new window)

Status report SUPPORTE funding of clinical trials in need

D1.1 Status report of EU and International ongoing/upcoming clinical trials (opens in new window)

Status report of EU and International ongoing/upcoming clinical trials.

D2.13 Assessment report on data quality and number of complete datasets (opens in new window)

Assessment report on data quality and number of complete datasets

D1.4 Status report of international ongoing clinical trials (opens in new window)

Status report of international ongoing clinical trials.

D2.12 Status report: SUPPORT-E funding of clinical trials in need (opens in new window)

Status report SUPPORTE funding of clinical trials in need

Final Dissemination and Exploitation Plan (video, press release, webpage update and management (opens in new window)

Final Dissemination and Exploitation Plan deliverable.

D7.3 Ethics review final report (opens in new window)

Ethics review final report

D2.9 Status report: SUPPORT-E funding of clinical trials in need (opens in new window)

Status report SUPPORTE funding of clinical trials in need

D1.3 Preliminary guidance document for monitored access (opens in new window)

Preliminary guidance document for monitored access.

D2.15 Status report: SUPPORT-E funding of clinical trials in need. (opens in new window)

Status report: SUPPORT-E funding of clinical trials in need.

D6.6 Technical report for laypersons (opens in new window)

Technical report for laypersons.A technical report (final) for laypersons (brochure) will be produced in order to describe the partners’ conclusions and achievements highlighting the methodology used and describing the recommended implementation process among EU Member States.

D4.4 Standardized quantitative and qualitative results on antibody content of all individual plasmas administered in hospitals linked to participating EBA members (opens in new window)

Standardized quantitative and qualitative results on antibody content of all individual plasmas administered in hospitals linked to participating EBA members

D7.2 Ethics review mid report (opens in new window)

Ethics review mid report.

D5.2 Recommendations report (opens in new window)

Interim Report and recommendations

Assessment report on data quality and number of complete datasets in EU CCP database (opens in new window)

Assessment report

D2.2 Status report: SUPPORT-E funding of clinical trials in need (opens in new window)

Status report SUPPORTE funding of clinical trials in need

D5.3 Final Recommendations Report (opens in new window)

Interim report and recommendations.

D4.2 Access to tests that qualify CP for clinical studies across Europe is assured for BE in need (opens in new window)

Access to tests that qualify CP for clinical studies across Europe is assured for BE in need.

D7.4 Ethics review final report (opens in new window)

Ethics review final report.

D2.8 Status report: interactions with supported clinical trials and monitored access programmes (opens in new window)

Status report interactions with supported clinical trials and monitored access programmes

D2.11 Status report: interactions with supported clinical trials and monitored access programmes (opens in new window)

Status report interactions with supported clinical trials and monitored access programmes

D1.6 Status report of international ongoing clinical trials (opens in new window)

Status report of international ongoing clinical trials

D2.18 Update on clinical trial COVIC-19: patient enrolment and patient characteristics, viral variants and CCP products (opens in new window)

Technical update deliverable

D2.14 Analysis report on database data and novel generated data (opens in new window)

Analysis report on database data and novel generated data

Quality Assessment and Standardization of Multiple SARS-CoV-2 Serological Assays in Superimmunized Individuals. (opens in new window)
D2.4 Status report: interactions with supported clinical trials and monitored access programmes (opens in new window)

Status report interactions with supported clinical trials and monitored access programmes

D4.1 Variability between tests across Europe mapped so standardization and calibration possible (opens in new window)

Variability between tests across Europe mapped so standardization and calibration possible .

D1.5 Status report of international ongoing clinical trials (opens in new window)

Status report of international ongoing clinical trials.

D2.1 Status report: interactions with supported clinical trials and monitored access programmes (opens in new window)

Status report interactions with supported clinical trials and monitored access programmes

D2.10 Assessment report on data quality and number of complete datasets (opens in new window)

Assessment report on data quality and number of complete datasets

D2.16 Update on clinical trial COVIC-19: patient enrolment and patient characteristics, viral variants and CCP products (opens in new window)

Technical update deliverable

D4.3 PoC of test measuring in vitro virus neutralizing activity on ELISA basis (opens in new window)

PoC of test measuring in vitro virus neutralizing activity on ELISA basis.

D5.1 Recommendations report (opens in new window)

Interim report and recommendations

D3.1 Dashboard report (opens in new window)

Dashboard report.

D6.4 Technical report for laypersons (opens in new window)

Technical report for laypersons.A technical report (interim) for laypersons (brochure) will be produced in order to describe the partners’ conclusions and achievements highlighting the methodology used and describing the recommended implementation process among EU Member States

D2.5 Status report: interactions with supported clinical trials and monitored access programmes (opens in new window)

Status report interactions with supported clinical trials and monitored access programmes

D2.3 Assessment report on data quality and number of complete datasets (opens in new window)

Assessment report on data quality and number of complete datasets

D1.2 Preliminary guidance document with assessment criteria for clinical trials (opens in new window)

Preliminary guidance document with assessment criteria for clinical trials.

D3.2 Data analysis report and statistical power calculations (opens in new window)

Data analysis report and statistical power calculations

Interim Analysis of the data from the EU CCP database (opens in new window)

This deliverable will analyze the datasets provided by the clinical study.

D2.19 Update on clinical trial COVIC-19: patient enrolment and patient characteristics, viral variants and CCP products (opens in new window)

Technical update deliverable

D6.7 Technical Report for laypersons (opens in new window)

Technical Report for laypersons deliverable.

Publications

Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19–Convalescent Donors (opens in new window)

Author(s): Bernd Jahrsdörfer, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Carolin Ludwig, Tatjana Schwarz, Sixten Körper, Markus Rojewski, Ramin Lotfi, Christoph Weinstock, Erhard Seifried, Victor Max Corman, Christian Drosten, Jan Münch, Hubert Schrezenmeier
Published in: The Journal of Immunology, Issue 206/11, 2021, Page(s) 2614-2622, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2100036

BNT162b2 Booster Vaccination Elicits Cross-Reactive Immunity Against SARS-CoV-2 Variants B.1.1.529 and B.1.617.2 in Convalescents of All Ages. (opens in new window)

Author(s): Jahrsdörfer B, Proffen M, Scholz J, Hägele J, Ludwig C, Vieweg C, Grempels A, Fabricius D, Lotfi R, Körper S, Adler G, Schrezenmeier H.
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2022.920210

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19: an international, randomised, open-label trial (opens in new window)

Author(s): Simone Hoffmann1*, Eva Schrezenmeier2*, Maxime Desmarets3,4, Fabian Halleck2, Antoine Durrbach5,6, Lynn Peters7, Anna-Teresa Tremmel8, Alina Seidel9, Marita Führer1, Friederike Bachmann2, Jens Schrezenmeier10, Jochen Greiner11, Sixten Körper1, Henrike Hofmann1, Carolin Ludwig1, Christiane Vieweg1, Bernd Jahrsdörfer1, Klemens Budde2, Michael Schmidt12, Jan Münch9, Nizar Joher5, Etienne Dagui
Published in: eBioMedicine (a Lancet Health Science journal), Issue 105653, 2025, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105613

B Cell Numbers Predict Humoral and Cellular Response Upon SARS-CoV-2 Vaccination Among Patients Treated With Rituximab (opens in new window)

Author(s): Stefanski AL, Rincon-Arevalo H, Schrezenmeier E, Karberg K, Szelinski F, Ritter J, Jahrsdörfer B, Schrezenmeier H, Ludwig C, Sattler A, Kotsch K, Chen Y, Claußnitzer A, Haibel H, Proft F, Guerra G, Durek P, Heinrich F, Ferreira-Gomes M, Burmester GR, Radbruch A, Mashreghi MF, Lino AC, Dörner T.
Published in: Arthritis Rheumatol, 2022, ISSN 2326-5191
Publisher: Arthritis Rheumatol
DOI: 10.1002/art.42060

B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients (opens in new window)

Author(s): Stefanski AL, Rincon-Arevalo H, Schrezenmeier E, Karberg K, Szelinski F, Ritter J, Chen Y, Jahrsdörfer B, Ludwig C, Schrezenmeier H, Lino AC, Dörner T
Published in: Frontier of Immunology, 2022, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2022.822885

B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients (opens in new window)

Author(s): Schrezenmeier E, Rincon-Arevalo H, Stefanski AL, Potekhin A, Straub-Hohenbleicher H, Choi M, Bachmann F, Pross V, Hammett C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Lino A, Eckardt KU, Kotsch K, Dörner T, Budde K, Sattler A, Halleck F
Published in: J Am Soc Nephrol, 2021, ISSN 1533-3450
Publisher: Journal of the American Society of Nephrology
DOI: 10.1681/asn.2021070966

A novel competition ELISA for the rapid quantification of SARS-CoV-2 neutralizing antibodies in convalescent plasma. (opens in new window)

Author(s): Elise Wouters; Caro Verbrugghe; Rosalie Devloo; Isabelle Debruyne; Dorien De Clippel; Leen Van Heddegem; Kristin Van Asch; Véronique Van Gaver; Miek Vanbrabant; An Muylaert; Veerle Compernolle; Hendrik B. Feys
Published in: TRANSFUSION, Issue 2, 2021, ISSN 0041-1132
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/trf.16652

Hyperimmune immunoglobulin for people with COVID‐19 (opens in new window)

Author(s): Kimber C, Valk SJ, Chai KL, Piechotta V, Iannizzi C, Monsef I, Wood EM, Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C, Estcourt LJ, Skoetz N.
Published in: The Cochrane Database of Systematic Reviews, 2023, Page(s) CD015167, ISSN 1465-1858
Publisher: The Cochrane Database of Systematic Reviews
DOI: 10.1002/14651858.cd015167.pub2

Effects of SARS-CoV-2 strain variation on virus neutralisation titres: therapeutic use of convalescent plasma. (opens in new window)

Author(s): Dung Nguyen; Julie Xiao; Peter Simmonds; Abigail Lamikanra; Valerie Odon; Jeremy Ratcliff; Alain Townsend; Alain Townsend; David J. Roberts; David J. Roberts; H. Harvala; H. Harvala
Published in: The journal of infectious diseases, Issue 2, 2021, ISSN 1537-6613
Publisher: The journal of infectious diseases.
DOI: 10.1093/infdis/jiab563

Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients. (opens in new window)

Author(s): Schrezenmeier E, Rincon-Arevalo H, Jens A, Stefanski AL, Hammett C, Osmanodja B, Koch N, Zukunft B, Beck J, Oellerich M, Proß V, Stahl C, Choi M, Bachmann F, Liefeldt L, Glander P, Schütz E, Bornemann-Kolatzki K, López Del Moral C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Eckardt KU, Lachmann N, Kotsch K, Dörner T, Halleck F, Sattler A, Budde K.
Published in: JCI Insight, 2022, ISSN 2379-3708
Publisher: JCI Insight
DOI: 10.1172/jci.insight.157836

Evaluation of SARS‐CoV‐2 antibody titers and potency for convalescent plasma donation: a brief commentary (opens in new window)

Author(s): Elise Wouters, Maurice Steenhuis, Hubert Schrezenmeier, Pierre Tiberghien, Heli Harvala, Hendrik B. Feys, Ellen Schoot
Published in: Vox Sanguinis, Issue 116/5, 2021, Page(s) 493-496, ISSN 0042-9007
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/vox.13060

Dynamics of antibodies to SARS-CoV-2 in convalescent plasma donors (opens in new window)

Author(s): Steenhuis, Maurice; van Mierlo, Gerard; Derksen, Ninotska Il; Ooijevaar-de Heer, Pleuni; Kruithof, Simone; Loeff, Floris L; Berkhout, Lea C; Linty, Federica; Reusken, Chantal; Reimerink, Johan; Hogema, Boris; Zaaijer, Hans; van de Watering, Leo; Swaneveld, Francis; van Gils, Marit J; Bosch, Berend Jan; van Ham, S Marieke; Ten Brinke, Anja; Vidarsson, Gestur; van der Schoot, Ellen C; Rispens, Theo;
Published in: VOLUME=10;ISSUE=5;TITLE=Clinical & translational immunology, Issue 2, 2021, ISSN 2050-0068
Publisher: John Wiley & Sons Australia, Ltd
DOI: 10.1002/cti2.1285

Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients (opens in new window)

Author(s): Arne Sattler, Eva Schrezenmeier, Ulrike A. Weber, Alexander Potekhin, Friederike Bachmann, Henriette Straub-Hohenbleicher, Klemens Budde, Elena Storz, Vanessa Proß, Yasmin Bergmann, Linda M.L. Thole, Caroline Tizian, Oliver Hölsken, Andreas Diefenbach, Hubert Schrezenmeier, Bernd Jahrsdörfer, Tomasz Zemojtel, Katharina Jechow, Christian Conrad, Sören Lukassen, Diana Stauch, Nils Lachmann, Mira
Published in: Journal of Clinical Investigation, Issue 131/14, 2021, ISSN 1558-8238
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci150175

SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data (opens in new window)

Author(s): Dung Nguyen, Peter Simmonds, Maurice Steenhuis, Elise Wouters, Daniel Desmecht, Mutien Garigliany, Marta Romano, Cyril Barbezange, Piet Maes, Bram Van Holm, Joaquín Mendoza, Salvador Oyonarte, Anders Fomsgaard, Ria Lassaunière, Eva Zusinaite, Katarina Resman Rus, Tatjana Avšič-Županc, Johan HJ Reimerink, Fiona Brouwer, Marieke Hoogerwerf, Chantal BEM Reusken, Gunnveig Grodeland, Sophie Le Cam
Published in: Eurosurveillance, Issue 26/27, 2021, ISSN 1560-7917
Publisher: European Center for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2021.26.27.2100568

Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization (opens in new window)

Author(s): Heli Harvala; Dung Nguyen; Peter Simmonds; Abigail A. Lamikanra; Hoi Pat Tsang; Ashley Otter; Piet Maes; Mhairi Webster; Adam Clarkson; Fotini Kaloyirou; Valerie Hopkins; Stephen M. Laidlaw; Miles Carroll; Ana Mora; Alexandra Griffiths; Sheila MacLennan; Lise Estcourt; David J. Roberts
Published in: Transfusion, Issue 1, 2022, ISSN 0041-1132
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/trf.16934

BNT162b2 Vaccination Elicits Strong Serological Immune Responses Against SARS-CoV-2 Including Variants of Concern in Elderly Convalescents (opens in new window)

Author(s): Jahrsdörfer B, Fabricius D, Scholz J, Ludwig C, Grempels A, Lotfi R, Körper S, Adler G, Schrezenmeier H
Published in: Front Immunol, 2021, ISSN 1664-3224
Publisher: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.743422

A novel competition ELISA for the selection of COVID-19 convalescent plasma donors

Author(s): Verbrugghe, C; Wouters, E; Compernolle, V; Feys, H.B.
Published in: 2021
Publisher: Ghent University Press

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