SUPporting high quality evaluation of COVID-19 convalescent Plasma thrOughoutT Europe

Projektinformationen

SUPPORT-E

ID Finanzhilfevereinbarung: 101015756

DOI

10.3030/101015756

Das Projekt endete am 1 März 2025

EK-Unterschriftsdatum 2 September 2020

Startdatum 1 Juli 2020

Enddatum 31 Dezember 2025

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 4 021 277,00

EU-Beitrag

€ 4 021 277,00

Koordiniert durch

EUROPEAN BLOOD ALLIANCE
Netherlands

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (46)

D3.4 Dashboard report

Dashboard report

Final recommendations for CCP use to treat COVID-19
D2.7 Assessment report on data quality and number of complete datasets

Assessment report on data quality and number of complete datasets

D7.1 Composition of the Scientific and Ethics Advisory Board

Composition of the Scientific and Ethics Advisory Board.

D2.6 Status report: SUPPORT-E funding of clinical trials in need.

Status report SUPPORTE funding of clinical trials in need

D1.1 Status report of EU and International ongoing/upcoming clinical trials

Status report of EU and International ongoing/upcoming clinical trials.

D2.13 Assessment report on data quality and number of complete datasets

Assessment report on data quality and number of complete datasets

D1.4 Status report of international ongoing clinical trials

Status report of international ongoing clinical trials.

D2.12 Status report: SUPPORT-E funding of clinical trials in need

Status report SUPPORTE funding of clinical trials in need

Final Dissemination and Exploitation Plan (video, press release, webpage update and management

Final Dissemination and Exploitation Plan deliverable.

D7.3 Ethics review final report

Ethics review final report

D2.9 Status report: SUPPORT-E funding of clinical trials in need

Status report SUPPORTE funding of clinical trials in need

D1.3 Preliminary guidance document for monitored access

Preliminary guidance document for monitored access.

D2.15 Status report: SUPPORT-E funding of clinical trials in need.

Status report: SUPPORT-E funding of clinical trials in need.

D6.6 Technical report for laypersons

Technical report for laypersons.A technical report (final) for laypersons (brochure) will be produced in order to describe the partners’ conclusions and achievements highlighting the methodology used and describing the recommended implementation process among EU Member States.

D4.4 Standardized quantitative and qualitative results on antibody content of all individual plasmas administered in hospitals linked to participating EBA members

Standardized quantitative and qualitative results on antibody content of all individual plasmas administered in hospitals linked to participating EBA members

D7.2 Ethics review mid report

Ethics review mid report.

D5.2 Recommendations report

Interim Report and recommendations

Assessment report on data quality and number of complete datasets in EU CCP database

Assessment report

D2.2 Status report: SUPPORT-E funding of clinical trials in need

Status report SUPPORTE funding of clinical trials in need

D5.3 Final Recommendations Report

Interim report and recommendations.

D4.2 Access to tests that qualify CP for clinical studies across Europe is assured for BE in need

Access to tests that qualify CP for clinical studies across Europe is assured for BE in need.

D7.4 Ethics review final report

Ethics review final report.

D2.8 Status report: interactions with supported clinical trials and monitored access programmes

Status report interactions with supported clinical trials and monitored access programmes

D2.11 Status report: interactions with supported clinical trials and monitored access programmes

Status report interactions with supported clinical trials and monitored access programmes

D1.6 Status report of international ongoing clinical trials

Status report of international ongoing clinical trials

D2.18 Update on clinical trial COVIC-19: patient enrolment and patient characteristics, viral variants and CCP products

Technical update deliverable

D2.14 Analysis report on database data and novel generated data

Analysis report on database data and novel generated data

Quality Assessment and Standardization of Multiple SARS-CoV-2 Serological Assays in Superimmunized Individuals.
D2.4 Status report: interactions with supported clinical trials and monitored access programmes

Status report interactions with supported clinical trials and monitored access programmes

D4.1 Variability between tests across Europe mapped so standardization and calibration possible

Variability between tests across Europe mapped so standardization and calibration possible .

D1.5 Status report of international ongoing clinical trials

Status report of international ongoing clinical trials.

D2.1 Status report: interactions with supported clinical trials and monitored access programmes

Status report interactions with supported clinical trials and monitored access programmes

D2.10 Assessment report on data quality and number of complete datasets

Assessment report on data quality and number of complete datasets

D2.16 Update on clinical trial COVIC-19: patient enrolment and patient characteristics, viral variants and CCP products

Technical update deliverable

D4.3 PoC of test measuring in vitro virus neutralizing activity on ELISA basis

PoC of test measuring in vitro virus neutralizing activity on ELISA basis.

D5.1 Recommendations report

Interim report and recommendations

D3.1 Dashboard report

Dashboard report.

D6.4 Technical report for laypersons

Technical report for laypersons.A technical report (interim) for laypersons (brochure) will be produced in order to describe the partners’ conclusions and achievements highlighting the methodology used and describing the recommended implementation process among EU Member States

D2.5 Status report: interactions with supported clinical trials and monitored access programmes

Status report interactions with supported clinical trials and monitored access programmes

D2.3 Assessment report on data quality and number of complete datasets

Assessment report on data quality and number of complete datasets

D1.2 Preliminary guidance document with assessment criteria for clinical trials

Preliminary guidance document with assessment criteria for clinical trials.

D3.2 Data analysis report and statistical power calculations

Data analysis report and statistical power calculations

Interim Analysis of the data from the EU CCP database

This deliverable will analyze the datasets provided by the clinical study.

D2.19 Update on clinical trial COVIC-19: patient enrolment and patient characteristics, viral variants and CCP products

Technical update deliverable

D6.7 Technical Report for laypersons

Technical Report for laypersons deliverable.

Open Research Data Pilot (3)

Data Management Plan update
D3.6 Data Management second status report

Data Management status report

D3.5 Data Management status report

Data management report

Websites, patent fillings, videos etc. (2)

D6.1 Project website and dissemination material

Project website and dissemination materia .

D6.5 Final Meeting-Stakeholder Conference

Final Meeting-Stakeholder Conference.

Veröffentlichungen

Peer reviewed articles (16)

Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19–Convalescent Donors

Autoren: Bernd Jahrsdörfer, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Carolin Ludwig, Tatjana Schwarz, Sixten Körper, Markus Rojewski, Ramin Lotfi, Christoph Weinstock, Erhard Seifried, Victor Max Corman, Christian Drosten, Jan Münch, Hubert Schrezenmeier
Veröffentlicht in: The Journal of Immunology, Ausgabe 206/11, 2021, Seite(n) 2614-2622, ISSN 0022-1767
Herausgeber: American Association of Immunologists
DOI: 10.4049/jimmunol.2100036

BNT162b2 Booster Vaccination Elicits Cross-Reactive Immunity Against SARS-CoV-2 Variants B.1.1.529 and B.1.617.2 in Convalescents of All Ages.

Autoren: Jahrsdörfer B, Proffen M, Scholz J, Hägele J, Ludwig C, Vieweg C, Grempels A, Fabricius D, Lotfi R, Körper S, Adler G, Schrezenmeier H.
Veröffentlicht in: Frontiers in Immunology, 2022, ISSN 1664-3224
Herausgeber: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2022.920210

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19: an international, randomised, open-label trial

Autoren: Simone Hoffmann1*, Eva Schrezenmeier2*, Maxime Desmarets3,4, Fabian Halleck2, Antoine Durrbach5,6, Lynn Peters7, Anna-Teresa Tremmel8, Alina Seidel9, Marita Führer1, Friederike Bachmann2, Jens Schrezenmeier10, Jochen Greiner11, Sixten Körper1, Henrike Hofmann1, Carolin Ludwig1, Christiane Vieweg1, Bernd Jahrsdörfer1, Klemens Budde2, Michael Schmidt12, Jan Münch9, Nizar Joher5, Etienne Dagui
Veröffentlicht in: eBioMedicine (a Lancet Health Science journal), Ausgabe 105653, 2025, ISSN 2352-3964
Herausgeber: Elsevier BV
DOI: 10.1016/j.ebiom.2025.105613

B Cell Numbers Predict Humoral and Cellular Response Upon SARS-CoV-2 Vaccination Among Patients Treated With Rituximab

Autoren: Stefanski AL, Rincon-Arevalo H, Schrezenmeier E, Karberg K, Szelinski F, Ritter J, Jahrsdörfer B, Schrezenmeier H, Ludwig C, Sattler A, Kotsch K, Chen Y, Claußnitzer A, Haibel H, Proft F, Guerra G, Durek P, Heinrich F, Ferreira-Gomes M, Burmester GR, Radbruch A, Mashreghi MF, Lino AC, Dörner T.
Veröffentlicht in: Arthritis Rheumatol, 2022, ISSN 2326-5191
Herausgeber: Arthritis Rheumatol
DOI: 10.1002/art.42060

B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients

Autoren: Stefanski AL, Rincon-Arevalo H, Schrezenmeier E, Karberg K, Szelinski F, Ritter J, Chen Y, Jahrsdörfer B, Ludwig C, Schrezenmeier H, Lino AC, Dörner T
Veröffentlicht in: Frontier of Immunology, 2022, ISSN 1664-3224
Herausgeber: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2022.822885

B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients

Autoren: Schrezenmeier E, Rincon-Arevalo H, Stefanski AL, Potekhin A, Straub-Hohenbleicher H, Choi M, Bachmann F, Pross V, Hammett C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Lino A, Eckardt KU, Kotsch K, Dörner T, Budde K, Sattler A, Halleck F
Veröffentlicht in: J Am Soc Nephrol, 2021, ISSN 1533-3450
Herausgeber: Journal of the American Society of Nephrology
DOI: 10.1681/asn.2021070966

A novel competition ELISA for the rapid quantification of SARS-CoV-2 neutralizing antibodies in convalescent plasma.

Autoren: Elise Wouters; Caro Verbrugghe; Rosalie Devloo; Isabelle Debruyne; Dorien De Clippel; Leen Van Heddegem; Kristin Van Asch; Véronique Van Gaver; Miek Vanbrabant; An Muylaert; Veerle Compernolle; Hendrik B. Feys
Veröffentlicht in: TRANSFUSION, Ausgabe 2, 2021, ISSN 0041-1132
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/trf.16652

Hyperimmune immunoglobulin for people with COVID‐19

Autoren: Kimber C, Valk SJ, Chai KL, Piechotta V, Iannizzi C, Monsef I, Wood EM, Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C, Estcourt LJ, Skoetz N.
Veröffentlicht in: The Cochrane Database of Systematic Reviews, 2023, Seite(n) CD015167, ISSN 1465-1858
Herausgeber: The Cochrane Database of Systematic Reviews
DOI: 10.1002/14651858.cd015167.pub2

Effects of SARS-CoV-2 strain variation on virus neutralisation titres: therapeutic use of convalescent plasma.

Autoren: Dung Nguyen; Julie Xiao; Peter Simmonds; Abigail Lamikanra; Valerie Odon; Jeremy Ratcliff; Alain Townsend; Alain Townsend; David J. Roberts; David J. Roberts; H. Harvala; H. Harvala
Veröffentlicht in: The journal of infectious diseases, Ausgabe 2, 2021, ISSN 1537-6613
Herausgeber: The journal of infectious diseases.
DOI: 10.1093/infdis/jiab563

Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients.

Autoren: Schrezenmeier E, Rincon-Arevalo H, Jens A, Stefanski AL, Hammett C, Osmanodja B, Koch N, Zukunft B, Beck J, Oellerich M, Proß V, Stahl C, Choi M, Bachmann F, Liefeldt L, Glander P, Schütz E, Bornemann-Kolatzki K, López Del Moral C, Schrezenmeier H, Ludwig C, Jahrsdörfer B, Eckardt KU, Lachmann N, Kotsch K, Dörner T, Halleck F, Sattler A, Budde K.
Veröffentlicht in: JCI Insight, 2022, ISSN 2379-3708
Herausgeber: JCI Insight
DOI: 10.1172/jci.insight.157836

Evaluation of SARS‐CoV‐2 antibody titers and potency for convalescent plasma donation: a brief commentary

Autoren: Elise Wouters, Maurice Steenhuis, Hubert Schrezenmeier, Pierre Tiberghien, Heli Harvala, Hendrik B. Feys, Ellen Schoot
Veröffentlicht in: Vox Sanguinis, Ausgabe 116/5, 2021, Seite(n) 493-496, ISSN 0042-9007
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/vox.13060

Dynamics of antibodies to SARS-CoV-2 in convalescent plasma donors

Autoren: Steenhuis, Maurice; van Mierlo, Gerard; Derksen, Ninotska Il; Ooijevaar-de Heer, Pleuni; Kruithof, Simone; Loeff, Floris L; Berkhout, Lea C; Linty, Federica; Reusken, Chantal; Reimerink, Johan; Hogema, Boris; Zaaijer, Hans; van de Watering, Leo; Swaneveld, Francis; van Gils, Marit J; Bosch, Berend Jan; van Ham, S Marieke; Ten Brinke, Anja; Vidarsson, Gestur; van der Schoot, Ellen C; Rispens, Theo;
Veröffentlicht in: VOLUME=10;ISSUE=5;TITLE=Clinical & translational immunology, Ausgabe 2, 2021, ISSN 2050-0068
Herausgeber: John Wiley & Sons Australia, Ltd
DOI: 10.1002/cti2.1285

Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients

Autoren: Arne Sattler, Eva Schrezenmeier, Ulrike A. Weber, Alexander Potekhin, Friederike Bachmann, Henriette Straub-Hohenbleicher, Klemens Budde, Elena Storz, Vanessa Proß, Yasmin Bergmann, Linda M.L. Thole, Caroline Tizian, Oliver Hölsken, Andreas Diefenbach, Hubert Schrezenmeier, Bernd Jahrsdörfer, Tomasz Zemojtel, Katharina Jechow, Christian Conrad, Sören Lukassen, Diana Stauch, Nils Lachmann, Mira
Veröffentlicht in: Journal of Clinical Investigation, Ausgabe 131/14, 2021, ISSN 1558-8238
Herausgeber: American Society for Clinical Investigation
DOI: 10.1172/jci150175

SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data

Autoren: Dung Nguyen, Peter Simmonds, Maurice Steenhuis, Elise Wouters, Daniel Desmecht, Mutien Garigliany, Marta Romano, Cyril Barbezange, Piet Maes, Bram Van Holm, Joaquín Mendoza, Salvador Oyonarte, Anders Fomsgaard, Ria Lassaunière, Eva Zusinaite, Katarina Resman Rus, Tatjana Avšič-Županc, Johan HJ Reimerink, Fiona Brouwer, Marieke Hoogerwerf, Chantal BEM Reusken, Gunnveig Grodeland, Sophie Le Cam
Veröffentlicht in: Eurosurveillance, Ausgabe 26/27, 2021, ISSN 1560-7917
Herausgeber: European Center for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2021.26.27.2100568

Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization

Autoren: Heli Harvala; Dung Nguyen; Peter Simmonds; Abigail A. Lamikanra; Hoi Pat Tsang; Ashley Otter; Piet Maes; Mhairi Webster; Adam Clarkson; Fotini Kaloyirou; Valerie Hopkins; Stephen M. Laidlaw; Miles Carroll; Ana Mora; Alexandra Griffiths; Sheila MacLennan; Lise Estcourt; David J. Roberts
Veröffentlicht in: Transfusion, Ausgabe 1, 2022, ISSN 0041-1132
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/trf.16934

BNT162b2 Vaccination Elicits Strong Serological Immune Responses Against SARS-CoV-2 Including Variants of Concern in Elderly Convalescents

Autoren: Jahrsdörfer B, Fabricius D, Scholz J, Ludwig C, Grempels A, Lotfi R, Körper S, Adler G, Schrezenmeier H
Veröffentlicht in: Front Immunol, 2021, ISSN 1664-3224
Herausgeber: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.743422

Thesis and dissertations (1)

A novel competition ELISA for the selection of COVID-19 convalescent plasma donors

Autoren: Verbrugghe, C; Wouters, E; Compernolle, V; Feys, H.B.
Veröffentlicht in: 2021
Herausgeber: Ghent University Press