A diagnostic test to improve surveillance and care of COVID-19 patients

Livrables

Public short video to introduce the project to the wide/lay public

A communication package will be issued for internal and external usage, incluidng logo, flyer and a project website.

Report of the COVIRNA final dissemination event It will include the final programme list of participants and main outcomes of the conference eg round table discussions

Transcriptomic alterations in SARS-COV-2 infected cardiovascular cells

scRNAseq to characterise transcriptional changes in each cell population in cardiac spheroids

Functional analysis of inflammatory and of vascular cell types

Report on the functional changes in monocytesmacrophages and vascular smooth muscle cells upon lncRNA gainloss of function manipulation

Design and synthesis of 10 GapmeRs or siRNAs and of viral vectors for 10 target lncRNAs

Report on the design and synthesis of siRNAs or singlestranded antisense oligonucleotides ASO that contain locked nucleic acid LNA modified nucleotides and lentiviral vectors for efficient silencingoverexpression of up to 10 endogenous lncRNAs from FIMICS panel

Mediation analysis for understanding direct and mediated effects of lncRNA

Report on the results of the mediation analysis and results describing lncRNAs with distinct direct effects or mediated effects via established CVD risk factors

Communication, dissemination and exploitation plan

The document will include a comprehensive Communication Dissemination and Exploitation plan including the elements of the project identity as well as all the necessary communication dissemination and useexploitation planning actions actors and channels and a set of KPIs in order to monitor proposed activities

Disease mortality classification

Generation of a classifier that can predict mortality in COVID-19 patients with reasonably high accuracy

Prediction of MACE

Generation of a classifier that can predict MACE in COVID-19 patients with reasonably high accuracy

Publications

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells

Auteurs: McCracken IR, Saginc G, He L, Huseynov A, Daniels A, Fletcher S, Peghaire C, Kalna V, Andaloussi-Mäe M, Muhl L, Craig NM, Griffiths SJ, Haas JG, Tait-Burkard C, Lendahl U, Birdsey GM, Betsholtz C, Noseda M, Baker AH, Randi AM
Publié dans: Circulation, Numéro 2021 Feb 23;143(8):865-868, 2021, Page(s) 865-868, ISSN 1524-4539
Éditeur: Lippincott Williams & Wilkins
DOI: 10.1161/circulationaha.120.052824

Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality

Auteurs: Madè A, Greco S, Vausort M, Miliotis M, Schordan E, Baksi S, Zhang L, Baryshnikova E, Ranucci M, Cardani R, Fagherazzi G, Ollert M, Tastsoglou S, Vatsellas G, Hatzigeorgiou A, Firat H, Devaux Y, Martelli F.
Publié dans: Scientific Reports, Numéro 12(1); Nov, 2022, 2022, Page(s) 20048, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-23922-2

FIMICS: A panel of long noncoding RNAs for cardiovascular conditions

Auteurs: Huseyin Firat, Lu Zhang, Shounak Baksi, Przemyslaw Leszek, Eric Schordan, Samir Ounzain, Jan Kottwitz, Dimitri Patriki, Bettina Heidecker, Thomas F Lüscher, Thierry Pedrazzini, Yvan Devaux ; EU-CardioRNA COST Action
Publié dans: Heliyon, 2023, ISSN 2405-8440
Éditeur: Elsevier
DOI: 10.1016/j.heliyon.2023.e13087

PPMS: A framework to Profile Primary MicroRNAs from Single-cell RNA-sequencing datasets

Auteurs: Ji J, Anwar M, Petretto E, Emanueli C, Srivastava PK.
Publié dans: Brief Bioinform, Numéro 2022 Nov 19;, 2022, Page(s) 23(6):1-7, ISSN 1477-4054
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbac419

Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage.

Auteurs: Avolio E, Srivastava PK, Ji J, Carrabba M, Tsang CTW, Gu Y, Thomas AC, Gupta K, Berger I, Emanueli C, Madeddu P.
Publié dans: Signal Transduct Target Ther, Numéro 2023 Jun 2, 2023, Page(s) (8)232 1-4, ISSN 2059-3635
Éditeur: Springer Nature-Nature Portfolio
DOI: 10.1038/s41392-023-01489-2

The role of the endothelium in SARS-CoV-2 infection and pathogenesis

Auteurs: 207. Passi R., Brittan M., Baker AH
Publié dans: Current Opinion in Physiology, 2023, ISSN 2468-8673
Éditeur: Elsevier
DOI: 10.1016/j.cophys.2023.100670

Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors.

Auteurs: Alessia Mongelli; Veronica Barbi; Michela Gottardi Zamperla; Sandra Atlante; Luana Forleo; Marialisa Nesta; Massimo Massetti; Alfredo Pontecorvi; Simona Nanni; Antonella Farsetti; Oronzo Catalano; Maurizio Bussotti; Laura Dalla Vecchia; Tiziana Bachetti; Fabio Martelli; Maria Teresa La Rovere; Carlo Gaetano
Publié dans: International Journal of Molecular Sciences, Numéro 2, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2021.04.23.21255973

Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129

Auteurs: Badimon L, Robinson EL, Jusic A, Carpusca I, deWindt LJ, Emanueli C, Ferdinandy P, Gu W, Gyongyosi M, Hackl M, Karaduzovic-Hadziabdic K, Lustrek M, Martelli F, Nham E, Potocnjak I, Satagopam V, Schneider R, Thum T, Devaux Y
Publié dans: Cardiovasc res, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab094

Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction

Auteurs: Bence Ágg, Péter Ferdinandy
Publié dans: Translational Epigenetics/Epigenetics in Cardiovascular Disease, Numéro Volume 24 6th March 2021, 2021, Page(s) 441-457, ISBN 978-0-12-822258-4
Éditeur: Elsevier, Academic Press 2021
DOI: 10.1016/b978-0-12-822258-4.00012-2

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