Livrables Websites, patent fillings, videos etc. (2) Project video Public short video to introduce the project to the wide/lay public Project logo, flyer and website A communication package will be issued for internal and external usage, incluidng logo, flyer and a project website. Documents, reports (6) Final dissemination event Report of the COVIRNA final dissemination event It will include the final programme list of participants and main outcomes of the conference eg round table discussions Transcriptomic alterations in SARS-COV-2 infected cardiovascular cells scRNAseq to characterise transcriptional changes in each cell population in cardiac spheroids Functional analysis of inflammatory and of vascular cell types Report on the functional changes in monocytesmacrophages and vascular smooth muscle cells upon lncRNA gainloss of function manipulation Design and synthesis of 10 GapmeRs or siRNAs and of viral vectors for 10 target lncRNAs Report on the design and synthesis of siRNAs or singlestranded antisense oligonucleotides ASO that contain locked nucleic acid LNA modified nucleotides and lentiviral vectors for efficient silencingoverexpression of up to 10 endogenous lncRNAs from FIMICS panel Mediation analysis for understanding direct and mediated effects of lncRNA Report on the results of the mediation analysis and results describing lncRNAs with distinct direct effects or mediated effects via established CVD risk factors Communication, dissemination and exploitation plan The document will include a comprehensive Communication Dissemination and Exploitation plan including the elements of the project identity as well as all the necessary communication dissemination and useexploitation planning actions actors and channels and a set of KPIs in order to monitor proposed activities Publications Peer reviewed articles (6) Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells Auteurs: McCracken IR, Saginc G, He L, Huseynov A, Daniels A, Fletcher S, Peghaire C, Kalna V, Andaloussi-Mäe M, Muhl L, Craig NM, Griffiths SJ, Haas JG, Tait-Burkard C, Lendahl U, Birdsey GM, Betsholtz C, Noseda M, Baker AH, Randi AM Publié dans: Circulation, Numéro 2021 Feb 23;143(8):865-868, 2021, Page(s) 865-868, ISSN 1524-4539 Éditeur: Lippincott Williams & Wilkins DOI: 10.1161/circulationaha.120.052824 Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality Auteurs: Madè A, Greco S, Vausort M, Miliotis M, Schordan E, Baksi S, Zhang L, Baryshnikova E, Ranucci M, Cardani R, Fagherazzi G, Ollert M, Tastsoglou S, Vatsellas G, Hatzigeorgiou A, Firat H, Devaux Y, Martelli F. Publié dans: Scientific Reports, Numéro 12(1); Nov, 2022, 2022, Page(s) 20048, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-022-23922-2 FIMICS: A panel of long noncoding RNAs for cardiovascular conditions Auteurs: Huseyin Firat, Lu Zhang, Shounak Baksi, Przemyslaw Leszek, Eric Schordan, Samir Ounzain, Jan Kottwitz, Dimitri Patriki, Bettina Heidecker, Thomas F Lüscher, Thierry Pedrazzini, Yvan Devaux ; EU-CardioRNA COST Action Publié dans: Heliyon, 2023, ISSN 2405-8440 Éditeur: Elsevier DOI: 10.1016/j.heliyon.2023.e13087 PPMS: A framework to Profile Primary MicroRNAs from Single-cell RNA-sequencing datasets Auteurs: Ji J, Anwar M, Petretto E, Emanueli C, Srivastava PK. Publié dans: Brief Bioinform, Numéro 2022 Nov 19;, 2022, Page(s) 23(6):1-7, ISSN 1477-4054 Éditeur: Oxford University Press DOI: 10.1093/bib/bbac419 Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage. Auteurs: Avolio E, Srivastava PK, Ji J, Carrabba M, Tsang CTW, Gu Y, Thomas AC, Gupta K, Berger I, Emanueli C, Madeddu P. Publié dans: Signal Transduct Target Ther, Numéro 2023 Jun 2, 2023, Page(s) (8)232 1-4, ISSN 2059-3635 Éditeur: Springer Nature-Nature Portfolio DOI: 10.1038/s41392-023-01489-2 The role of the endothelium in SARS-CoV-2 infection and pathogenesis Auteurs: 207. Passi R., Brittan M., Baker AH Publié dans: Current Opinion in Physiology, 2023, ISSN 2468-8673 Éditeur: Elsevier DOI: 10.1016/j.cophys.2023.100670 Non-peer reviewed articles (2) Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors. Auteurs: Alessia Mongelli; Veronica Barbi; Michela Gottardi Zamperla; Sandra Atlante; Luana Forleo; Marialisa Nesta; Massimo Massetti; Alfredo Pontecorvi; Simona Nanni; Antonella Farsetti; Oronzo Catalano; Maurizio Bussotti; Laura Dalla Vecchia; Tiziana Bachetti; Fabio Martelli; Maria Teresa La Rovere; Carlo Gaetano Publié dans: International Journal of Molecular Sciences, Numéro 2, 2021, ISSN 1422-0067 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.1101/2021.04.23.21255973 Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129 Auteurs: Badimon L, Robinson EL, Jusic A, Carpusca I, deWindt LJ, Emanueli C, Ferdinandy P, Gu W, Gyongyosi M, Hackl M, Karaduzovic-Hadziabdic K, Lustrek M, Martelli F, Nham E, Potocnjak I, Satagopam V, Schneider R, Thum T, Devaux Y Publié dans: Cardiovasc res, 2021, ISSN 0008-6363 Éditeur: Elsevier BV DOI: 10.1093/cvr/cvab094 Book chapters (1) Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction Auteurs: Bence Ágg, Péter Ferdinandy Publié dans: Translational Epigenetics/Epigenetics in Cardiovascular Disease, Numéro Volume 24 6th March 2021, 2021, Page(s) 441-457, ISBN 978-0-12-822258-4 Éditeur: Elsevier, Academic Press 2021 DOI: 10.1016/b978-0-12-822258-4.00012-2 Recherche de données OpenAIRE... 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