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International consortium for integrative genomics prediction

Objective

The aim of INTERVENE is to develop and test next generation tools for disease prevention, diagnosis, and personalised treatment utilizing the first US-European pool of genomic and health data and integrating longitudinal and disease-relevant -omics data into genetic risk scores. Resulting in unprecedented potential for prediction, diagnosis, and personalised treatments for complex and rare diseases. Some of the largest biobanks in Europe and two in the USA will be securely linked and harmonized in a GDPR-compliant repository with data from more than 1.7 million genomes. INTERVENE will demonstrate the potential and benefits of powerful AI technologies on the next generation of integrative genetic scores (IGS). The clinical and economic benefits of IGS will be evaluated in key disease areas with major public health burden. Here, the newly developed IGS will be taken into clinical environment and their real-world benefits will be evaluated together with clinical experts, European patients advocate groups and medical societies and considering regulatory and ethical implications. Thus, a framework for legally and ethically responsible translation into wider clinical practice will be developed. Moreover, the partners will develop and test the role of IGS in several rare diseases as well as COVID-19 infection and severity. Importantly, to support the application of IGS via public-private partnerships including clinical practitioners, an AI-enabled federated data analysis platform, the ‘IGS4EU’ platform, will be developed for automated IGS generation and interpretation for end-users. Additionally, the IGS4EU platform will allow access of the INTERVENE data and the methodology know-how to the AI community through a competition-based benchmarking environment. In the long term, the IGS4EU platform aims to grow the disease coverage and enable a wide adoption of IGS as a gold standard in clinical research and practice.

Field of science

  • /natural sciences/computer and information sciences/data science/data analysis
  • /medical and health sciences/health sciences/public and environmental health

Call for proposal

H2020-SC1-FA-DTS-2020-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

HELSINGIN YLIOPISTO
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 157 250

Participants (17)

IBM RESEARCH GMBH
Switzerland
EU contribution
€ 523 213,75
Address
Saeumerstrasse 4
8803 Rueschlikon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 569 818,75
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 552 043,75
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 258 000
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
VANDERBILT UNIVERSITY MEDICAL CENTER
United States
EU contribution
€ 249 993,75
Address
1161 21St Avenue South
37232 Nashville
Activity type
Research Organisations
TARTU ULIKOOL
Estonia
EU contribution
€ 1 120 656,25
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)
Austria
EU contribution
€ 349 975
Address
Neue Stiftingtalstrasse 2/B/6
8010 Graz
Activity type
Research Organisations
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 354 375
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY
Finland
EU contribution
€ 921 750
Address
Keilaranta 14
02101 Espoo
Activity type
Other
HASSO-PLATTNER-INSTITUT FUR DIGITAL ENGINEERING GGMBH
Germany
EU contribution
€ 538 676,25
Address
Prof Dr Helmert Strasse 2-3
14482 Potsdam
Activity type
Research Organisations
AALTO KORKEAKOULUSAATIO SR
Finland
EU contribution
€ 360 187,50
Address
Otakaari 1
02150 Espoo
Activity type
Higher or Secondary Education Establishments
HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Finland
EU contribution
€ 264 617,50
Address
Stenbackinkatu 9
00029 Helsinki
Activity type
Research Organisations
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 216 161,25
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
THE GENERAL HOSPITAL CORPORATION
United States
EU contribution
€ 247 342,50
Address
Fruit Street 55
02114 Boston Ma
Activity type
Other
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 294 535
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
EUROPEAN CANCER PATIENT COALITION
Belgium
EU contribution
€ 250 000
Address
Rue Montoyer 40
1000 Bruxelles
Activity type
Other
TTOPSTART BV
Netherlands
EU contribution
€ 206 343,75
Address
Euclideslaan 1
3584 BL Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)