Project description DEENESFRITPL Harnessing artificial intelligence to predict genetic risk for common and rare diseases Different people develop disease and respond to treatments differently. Moving away from the one-size-fits-all approach, personalised medicine pursues treatment options tailored to the genetic profile of individuals. The EU-funded INTERVENE project will develop next-generation tools for disease prevention, diagnosis and personalised treatment. INTERVENE will use powerful artificial intelligence technologies on a vast and diverse US-European pool of genomic and health data to calculate genetic risk scores that predict an individual’s susceptibility to a particular disease. The risk scores will be tested in clinical trials focusing on devastating common diseases, such as diabetes, cancer, and cardiovascular disease. INTERVENE will also develop and test the role of risk scores in several rare diseases as well as COVID-19 infection and severity. Show the project objective Hide the project objective Objective The aim of INTERVENE is to develop and test next generation tools for disease prevention, diagnosis, and personalised treatment utilizing the first US-European pool of genomic and health data and integrating longitudinal and disease-relevant -omics data into genetic risk scores. Resulting in unprecedented potential for prediction, diagnosis, and personalised treatments for complex and rare diseases. Some of the largest biobanks in Europe and two in the USA will be securely linked and harmonized in a GDPR-compliant repository with data from more than 1.7 million genomes. INTERVENE will demonstrate the potential and benefits of powerful AI technologies on the next generation of integrative genetic scores (IGS). The clinical and economic benefits of IGS will be evaluated in key disease areas with major public health burden. Here, the newly developed IGS will be taken into clinical environment and their real-world benefits will be evaluated together with clinical experts, European patients advocate groups and medical societies and considering regulatory and ethical implications. Thus, a framework for legally and ethically responsible translation into wider clinical practice will be developed. Moreover, the partners will develop and test the role of IGS in several rare diseases as well as COVID-19 infection and severity. Importantly, to support the application of IGS via public-private partnerships including clinical practitioners, an AI-enabled federated data analysis platform, the ‘IGS4EU’ platform, will be developed for automated IGS generation and interpretation for end-users. Additionally, the IGS4EU platform will allow access of the INTERVENE data and the methodology know-how to the AI community through a competition-based benchmarking environment. In the long term, the IGS4EU platform aims to grow the disease coverage and enable a wide adoption of IGS as a gold standard in clinical research and practice. Fields of science natural sciencescomputer and information sciencesdata sciencemedical and health scienceshealth sciencespublic healthmedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesnatural sciencesbiological sciencesgeneticsgenomes Keywords Complex disease Rare disease Biobank Genomics Longitudinal health data Polygenic risk scores Predictive genetic scores Personalised treatment Disease prevention Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.5. - Methods and data Topic(s) DT-TDS-04-2020 - AI for Genomics and Personalised Medicine Call for proposal H2020-SC1-FA-DTS-2018-2020 See other projects for this call Sub call H2020-SC1-FA-DTS-2020-1 Funding Scheme RIA - Research and Innovation action Coordinator HELSINGIN YLIOPISTO Net EU contribution € 2 288 500,00 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto Finland See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 288 500,00 Participants (17) Sort alphabetically Sort by Net EU contribution Expand all Collapse all IBM RESEARCH GMBH Participation ended Switzerland Net EU contribution € 0,00 Address SAEUMERSTRASSE 4 8803 Rueschlikon See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany Net EU contribution € 1 569 818,75 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 569 818,75 UNIVERSITA DEGLI STUDI DI SIENA Italy Net EU contribution € 552 043,75 Address VIA BANCHI DI SOTTO 55 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 552 043,75 NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Norway Net EU contribution € 258 000,00 Address HOGSKOLERINGEN 1 7491 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 258 000,00 TARTU ULIKOOL Estonia Net EU contribution € 1 120 656,25 Address ULIKOOLI 18 51005 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 120 656,25 BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC) Austria Net EU contribution € 349 975,00 Address NEUE STIFTINGTALSTRASSE 2/B/6 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 349 975,00 TECHNISCHE UNIVERSITAET MUENCHEN Germany Net EU contribution € 354 375,00 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 354 375,00 CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY Finland Net EU contribution € 921 750,00 Address KEILARANTA 14 02101 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 921 750,00 HASSO-PLATTNER-INSTITUT FUR DIGITAL ENGINEERING GGMBH Germany Net EU contribution € 753 201,25 Address PROF DR HELMERT STRASSE 2-3 14482 Potsdam See on map Region Brandenburg Brandenburg Potsdam Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 753 201,25 AALTO KORKEAKOULUSAATIO SR Finland Net EU contribution € 537 626,25 Address OTAKAARI 1 02150 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 537 626,25 HUS-YHTYMA Finland Net EU contribution € 264 617,50 Address STENBACKINKATU 9 00029 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 264 617,50 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 216 161,25 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 216 161,25 THE GENERAL HOSPITAL CORPORATION United States Net EU contribution € 247 342,50 Address FRUIT STREET 55 02114 Boston Ma See on map Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 247 342,50 UNIVERSITA DEGLI STUDI DI TORINO Italy Net EU contribution € 294 535,00 Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 294 535,00 EUROPEAN CANCER PATIENT COALITION Belgium Net EU contribution € 250 000,00 Address AVENUE DES ARTS 6 1210 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 250 000,00 TTOPSTART BV Netherlands Net EU contribution € 206 343,75 Address LAAN VAN ZUID HOORN 15 2289 DC Rijswijk See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 206 343,75 QUEEN MARY UNIVERSITY OF LONDON United Kingdom Net EU contribution € 249 993,75 Address 327 MILE END ROAD E1 4NS London See on map Region London Inner London — East Tower Hamlets Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 249 993,75