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DEEP BRAIN PHOTONIC TOOLS FOR CELL-TYPE SPECIFIC TARGETING OF NEURAL DISEASES

Objective

While brain disorders have different etiology and stem from distinct molecular and cellular dysfunctions, due to limitation in current technology they all share an incomplete understanding of the anatomical and functional alterations occurring in hard-to-access deep regions of the brain. DEEPER aims at tackling this fundamental challenge by developing an entire new class of photonic tools for imaging and manipulating neuronal activity in the deep brain with unprecedented penetration depth, resolution, sensitivity, specificity and depth of focus. Technology development in DEEPER will be driven by medical expertise and market requirements and it will be organized in three pillars focusing on: i) novel high-efficiency molecular sensors and actuators; ii) minimally invasive probes for monitoring and perturbing large populations of cells; iii) next generation multiphoton microscopes and microendoscopes. In a fourth pillar, this technological platform will enable a number of clinically relevant experiments which will contribute to reveal the molecular and cellular dysfunctions underlying the pathogenesis of specific neurological (addiction, chronic pain, Alzheimer’s disease) and psychiatric disorders (depression, schizophrenia, and autism). By shedding new light on the pathogenesis of disorders, which dramatically touch the lives of millions, DEEPER has the potential to profoundly impact our society. Moreover, in DEEPER technologists, neuroscientists, clinical and pre-clinical experts will bring the results from laboratory research to market supported by the SMEs in the consortium and by the companies and experts in the advisory board. This will make the translation and exploitation of the DEEPER technologies fast and effective, building a value chain with strong translational appeal that will strengthen Europe’s industrial position in the biophotonics market for optical neural interfaces, microscopy, and microendoscopy.

Field of science

  • /social sciences/economics and business/business and management/commerce

Call for proposal

H2020-ICT-2020-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Address
Via Morego 30
16163 Genova
Italy
Activity type
Research Organisations
EU contribution
€ 1 241 237,50

Participants (11)

UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 615 000
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF STRATHCLYDE
United Kingdom
EU contribution
€ 699 920
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 478 125
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 250 000
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 427 240
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
USTAV PRISTROJOVE TECHNIKY AVCR VVI
Czechia
EU contribution
€ 402 500
Address
Kralovopolska 147
612 64 Brno
Activity type
Research Organisations
SORBONNE UNIVERSITE
France
EU contribution
€ 402 500
Address
21 Rue De L'ecole De Medecine
75006 Paris
Activity type
Higher or Secondary Education Establishments
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 437 658,75
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain
EU contribution
€ 438 125
Address
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Activity type
Research Organisations
ATLAS NEUROENGINEERING BVBA
Belgium
EU contribution
€ 198 950
Address
Maria Theresiastraat 91/0202
3000 Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OPTOGENIX SRL
Italy
EU contribution
€ 206 250
Address
Via Barsanti C/o Istituto Italiano Di Tecnologia
73010 Arnesano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)