Finding Endometriosis using Machine Learning

Informations projet

FEMaLe

N° de convention de subvention: 101017562

DOI

10.3030/101017562

Projet clôturé

Date de signature de la CE 15 Decembre 2020

Date de début 1 Janvier 2021

Date de fin 31 Decembre 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 944 134,50

Contribution de l’UE

€ 5 944 134,50

Coordonné par

AARHUS UNIVERSITET
Denmark

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (32)

Innovation and Intellectual Property management plan and reporting M37

A comprehensive collection of instruments to assist generate the effective protection of the innovation frameworks developed by the project.

Translation of Lucy App

Translate Android application from Hungarian into Danish English and Swedish

Innovation and Intellectual Property management plan and reporting M47

A comprehensive collection of instruments to assist generate the effective protection of the innovation frameworks developed by the project.

Innovation and Intellectual Property management plan and reporting M26

A comprehensive collection of instruments to assist generate the effective protection of the innovation frameworks developed by the project.

All WP IMA reports M42

All WP IMA reports [M6, M12, M18, M24, M30, M36, M42, M48]Lead: IAAD (P10). A comprehensive digital compendium of IMA results incorporating decision-making processes to improve and validate project’s activities

White paper on RRI-oriented and Open Science health and care systems

A comprehensive provision gathered in a digital format document and incorporating a dynamic set of information.

Risk classifier

A classifier identifying individuals with high and low risk of having endometriosis

Data-driven digital management platform M11

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information a solid leanagile software instrument to assist generate the effective management of the project and the Data Management Plan DPM

Project code guidelines

Leader IAAD P10 A comprehensive provision gathered in a digital format document and incorporating a dynamic set of information

White paper on ethical health and care systems

A comprehensive provision gathered in a digital format document and incorporating a dynamic set of information.

Data-driven digital management platform M35

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information, a solid lean-agile software instrument to assist generate the effective management of the project and the Data Management Plan (DPM)

Dissemination, exploitation, communication, and synergies strategy

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information

Lucy App Baseline Questionnaire module

Translated and tested Lucy App BQ module to be used in each target country

Dissemination package

A comprehensive collection of instruments to assist generate the effective visibility and impact of the project

Exploitation of results plan M47

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information.

Cost-effective IMA methods digital compendium and facilitators/multipliers

Lead AU P1 A comprehensive digital compendium of actionable and deployable information and a group of 10 facilitators

Synergies action plan

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information

White paper on gender-based and inclusive health and care systems

A comprehensive provision gathered in a digital format document and incorporating a dynamic set of information.

Biological markers

Risk variants and biomarkers that define biological, endometriosis subtypes.

Innovation and Intellectual Property management plan and reporting M14

A comprehensive collection of instruments to assist generate the effective protection of the innovation frameworks developed by the project

Project impact action strategy (PIAS)

Lead EQUIP P4 A comprehensive blueprint with actionable and deployable information encompassing details on pathways for synergies with other IMA and good practices leverageuptake

Baseline Questionnaire

Translated and validated baseline questionnaire to be used in each target country

Validated English and Hungarian versions of MY-ENDO

Translation and validation of English and Hungarian versions of MY-ENDO.

Data-driven digital management platform M47

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information, a solid lean-agile software instrument to assist generate the effective management of the project and the Data Management Plan (DPM)

Exploitation of results plan M38

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information.

All WP IMA reports [M30,

All WP IMA reports [M6, M12, M18, M24, M30, M36, M42, M48]Lead: IAAD (P10). A comprehensive digital compendium of IMA results incorporating decision-making processes to improve and validate project’s activities

Data-driven digital management platform M3

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information a solid leanagile software instrument to assist generate the effective management of the project and the Data Management Plan DPM

Subtype characteristics

Clinical characteristics, risk factors, and potential drug targets for major biological subtypes.

All WP IMA reports M12,

All WP IMA reports M6 M12 M18 M24 M30 M36 M42 M48Lead IAAD P10 A comprehensive digital compendium of IMA results incorporating decisionmaking processes to improve and validate projects activities

All WP IMA reports M6

All WP IMA reports M6 M12 M18 M24 M30 M36 M42 M48Lead IAAD P10 A comprehensive digital compendium of IMA results incorporating decisionmaking processes to improve and validate projects activities

FEMALE WEBSITE

FEMALE Website

Exploitation of results plan M28

A comprehensive provision gathered in a digital format document and incorporating an actionable set of practical information.

Other (9)

Deep learning algorithm to automatically determinate the division plane

Machine learning technology to automatize the determination of the division plane around endometriotic lesions.

Lifestyle module of the Lucy App

Lifestyle module, integrated into the Lucy App.

Computer vision-based software for real time assessment of endometriosis

The tool allows an automatic and objective confirmation of the diagnosis and assessment of the stage and extension of the disease evaluated during laparoscopy.

Computer vision-based software for real time guided surgery of endometriosis

Integration of the validated algorithm to the SurgAR software for a real time augmented reality guided surgery.

Patient global profile

Self-improving system for health monitoring in people with endometriosis. We expect to deliver a digital footprint of patient profiles.

Dietary module of the Lucy App

Dietary module, integrated into the Lucy App.

Clinical decision support tool

Clinical decision tools based on biological subtypes with the potential to guide treatment.

Lucy App MY-ENDO module

Implementation of MY-ENDO (self-guided) in the Lucy App

Deep learning algorithm to automatically determinate the stage of endometriosis

Machine learning technology to automatize the evaluation of the endometriosis specific score.

Open Research Data Pilot (3)

Data Management Plan updated

DMP updated final

Data Management final

DMP final

Data Management Plan Initial

Data Management Plan DMP initial

Websites, patent fillings, videos etc. (4)

Dataset of laparoscopic dicomised videos with metadata

A total number of 1000 surgeries will be collected

Post-Operative Dataset of laparoscopic semantic annotated images

Between 100,000-200,000 images or short videos will be annotated.

Dataset of laparoscopic dicomised videos M9

A total number of 200 surgeries will be collected

Dataset of laparoscopic semantic annotated images

Between 50000100000 images or short videos will be annotated

Demonstrators, pilots, prototypes (1)

Pilot version of MY-ENDO

Development and feasibility of MYENDO

Publications

Peer reviewed articles (16)

Temporal and regional differences in the incidence of hospital-diagnosed endometriosis: a Danish population-based study

Auteurs: Illum LRH, Forman A, Melgaard A, Hansen KE, Hansen SN, Nyegaard M, Hummlshoj L, Rytter D
Publié dans: Acta Obstetrica et Gynecologica Scandinavia, Numéro 101(7), 2022, Page(s) 737-746, ISSN 0001-6349
Éditeur: Wiley-Blackwell
DOI: 10.1111/aogs.14364

Consensus on Symptom Selection for Endometriosis Questionnaires: A Modified e‐Delphi Study

Auteurs: Tong Zhu, Henrik Marschall, Karina E. Hansen, Andrew W. Horne, Lucky Saraswat, Krina T. Zondervan, Stacey A. Missmer, Lone Hummelshoj, Atilla Bokor, Camilla S. Østrup, Anna Melgaard, Dorte Rytter
Publié dans: BJOG: An International Journal of Obstetrics & Gynaecology, 2025, ISSN 1470-0328
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/1471-0528.18066

Association between endometriosis and working life among Danish women

Auteurs: Eeva-Liisa Røssell, Oleguer Plana-Ripoll, Marie Josiasen, Karina Ejgaard Hansen, Bodil Hammer Bech, Dorte Rytter
Publié dans: Human Reproduction, 2025, ISSN 0268-1161
Éditeur: Oxford University Press
DOI: 10.1093/humrep/deae298

Psychological interventions improve quality of life despite persistent pain in endometriosis: results of a 3-armed randomized controlled trial

Auteurs: K. E. Hansen, B. Brandsborg, U. S. Kesmodel, A. Forman, M. Kold, R. Pristed, O. Donchulyesko, D. Hartwell, L. Vase
Publié dans: Quality of Life Research, Numéro 32, 2023, Page(s) 1727-1744, ISSN 0962-9343
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s11136-023-03346-9

Exploring pre-diagnosis hospital contacts in women with endometriosis using ICD-10: a Danish case–control study

Auteurs: Anna Melgaard, Claus Høstrup Vestergaard, Ulrik Schiøler Kesmodel, Bettina Wulff Risør, Axel Forman, Krina T Zondervan, Mintu Nath, Dolapo Ayansina, Philippa T K Saunders, Andrew W Horne, Lucky Saraswat, Dorte Rytter
Publié dans: Human Reproduction, Numéro 40, 2025, Page(s) 280-288, ISSN 0268-1161
Éditeur: Oxford University Press
DOI: 10.1093/humrep/deae273

Endometriosis: time to think differently (and together)

Auteurs: Sharon Dixon, Rebecca Mawson, Ulrik Bak Kirk, Andrew W Horne
Publié dans: British Journal of General Practice, Numéro 74, 2024, Page(s) 200-201, ISSN 0960-1643
Éditeur: Royal College of General Practitioners
DOI: 10.3399/bjgp24x737085

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Auteurs: Nilufer Rahmioglu, Sally Mortlock, Marzieh Ghiasi, Peter L. Møller, Lilja Stefansdottir, Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H. Law, Yadav Sapkota, Paraskevi Christofidou, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Błażej Marciniak, Margit Nõukas, Danielle Perro, Eeva Sliz, Marta Sobalska-Kwapis, Gudmar Thorleifsson, Nura F. Topbas-
Publié dans: Nature Genetics, Numéro 55, 2023, Page(s) 423–436, ISSN 1546-1718
Éditeur: Springer Nature
DOI: 10.1038/s41588-023-01323-z

The lived experiences of endometriosis in adolescence—A critical hermeneutic perspective

Auteurs: Liv Juul Nielsen, Katja Poulsen, Anders Lundme Funch, Kirsten Schultz Petersen
Publié dans: Scandinavian Journal of Caring Sciences, Numéro 37, 2023, Page(s) 1038-1047, ISSN 0283-9318
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/scs.13176

Avenues of reflection for endometriosis research in France

Auteurs: Jean Rosenbaum, Nicolas Bourdel, Saadi Khochbin, Marina Kvaskoff, Sachiko Matsuzaki, Fatima Mechta-Grigoriou, Nicola Pluchino, Olivier Sandra, Daniel Vaiman
Publié dans: Medecine sciences, Numéro 3(38), 2022, Page(s) 274–279, ISSN 0767-0974
Éditeur: Editions E D K
DOI: 10.1051/medsci/2022027

Understanding endometriosis underfunding and its detrimental impact on awareness and research

Auteurs: Ulrik Bak Kirk, Anne Sofie Bank-Mikkelsen, Dorte Rytter, Dorthe Hartwell, Henrik Marschall, Mette Nyegaard, Mikkel Seyer-Hansen, Karina Ejgaard Hansen
Publié dans: npj Women's Health, Numéro 2, 2024, ISSN 2948-1716
Éditeur: Springer Nature
DOI: 10.1038/s44294-024-00048-6

Not “just a bad period”— The impact of a co-created endometriosis social media health campaign: a mixed methods study

Auteurs: Ditte Bonde Stanek, Ida Hestbjerg, Karina Ejgaard Hansen, Maria Kathryn Tomlinson, Ulrik Bak Kirk
Publié dans: Frontiers in Communication, Numéro 8, 2023, ISSN 2297-900X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcomm.2023.1154297

Danish translation, cross-cultural adaptation, and electronic migration of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project Endometriosis Patient Questionnaire

Auteurs: Line Holdgaard Thomsen; Laura Emilie Vexø; Tine Henrichsen Schnack; Karina Ejgaard Hansen; Axel Forman; Dorthe Hartwell; Henriette Svarre Nielsen; Lone Hummelshoj; Mette Nyegaard; Mette Elkjær Madsen
Publié dans: Front. Glob. Womens Health, Numéro 4, 2023, ISSN 2673-5059
Éditeur: Frontiers Media SA
DOI: 10.3389/fgwh.2023.1102006

Utilization of healthcare prior to endometriosis diagnosis: a Danish case–control study

Auteurs: Anna Melgaard, Claus Høstrup Vestergaard, Ulrik Schiøler Kesmodel, Bettina Wulff Risør, Axel Forman, Krina Zondervan, Bodil Hammer Bech, Dorte Rytter
Publié dans: Human Reproduction, Numéro 38(10), 2023, Page(s) 1910–1917, ISSN 1460-2350
Éditeur: European Society of Human Reproduction and Embryology
DOI: 10.1093/humrep/dead164

FEMaLe: The use of machine learning for early diagnosis of endometriosis based on patient self-reported data—Study protocol of a multicenter trial

Auteurs: Dora B. Balogh, Gernot Hudelist, Dmitrijs Bļizņuks, Jayanth Raghothama, Christian M. Becker, Roman Horace, Harald Krentel, Andrew W. Horne, Nicolas Bourdel, Gabriella Marki, Carla Tomassetti, Ulrik Bak Kirk, Nandor Acs, Attila Bokor
Publié dans: PLOS ONE, Numéro 19, 2024, Page(s) e0300186, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0300186

Prevalence and sociodemographic distribution of endometriosis symptoms and indicators in Denmark

Auteurs: Marie Josiasen, Eeva-Liisa Røssell, Tong Zhu, Anna Melgaard, Lucky Saraswat, Andrew W. Horne, Karina Ejgaard Hansen, Dorte Rytter
Publié dans: European Journal of Obstetrics & Gynecology and Reproductive Biology, Numéro 307, 2025, Page(s) 109-120, ISSN 0301-2115
Éditeur: Elsevier BV
DOI: 10.1016/j.ejogrb.2025.01.051

Meeting abstracts of the 1st Surgical AI Conference

Auteurs: Academy Orsi
Publié dans: Artificial Intelligence Surgery, Numéro 4, 2024, Page(s) 1-6, ISSN 2771-0408
Éditeur: Orsi Academy
DOI: 10.20517/ais.2024.02