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Digital twins for model-driven non-invasive electrical brain stimulation

Objective

Neuropsychiatric disorders are a leading cause of global disability-adjusted life years, and solutions are lacking. Can digital twins be useful? At least in some cases, we hold they will be central to progress. Recent findings suggest that non-invasive brain stimulation may be a valuable option in conditions such as epilepsy or Alzheimer's (AD). Still, a better understanding of mechanisms and patient-specific factors is needed. Personalized hybrid brain models uniting the physics of electromagnetism with physiology – neurotwins or NeTs – are poised to play a fundamental role in understanding and optimizing the effects of stimulation at the individual level. We ambition to deliver disruptive solutions through model-driven, individualized therapy. We will build a computational framework – weaved and validated across scales and levels of detail– to represent the mechanisms of interaction of electric fields with brain networks and assimilate neuroimaging data. This will allow us to characterize the dynamical landscape of the individual brain and define strategies to restore healthy dynamics. Benefitting from existing databases of healthy and AD individuals, we will deliver the first human and rodent NeTs predicting the effects of stimulation on dynamics. We will then collect detailed multimodal measurements in mice and humans to improve the predictive power of local and whole-brain models under the effects of electrical stimulation, and translate these findings into a technology pipeline for the design of new personalized neuromodulation protocols which we will test in a cohort of AD patients and healthy controls in randomized double-blinded studies. With research at the intersecting frontier of nonlinear dynamics, network theory, biophysics, engineering, neuroscience, clinical research, and ethics, Neurotwin will deliver model-driven breakthroughs in basic and clinical neuroscience, with patients ultimately benefiting from safe, individualized therapy solutions.

Field of science

  • /natural sciences/physical sciences/electromagnetism and electronics/electromagnetism
  • /natural sciences/biological sciences/neurobiology

Call for proposal

H2020-FETPROACT-2020-2
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Funding Scheme

RIA - Research and Innovation action

Coordinator

NEUROELECTRICS BARCELONA SL
Address
Av. Tibidabo 47 Bis
08035 Barcelona
Spain
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 844 750

Participants (6)

UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 664 650
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD PABLO DE OLAVIDE
Spain
EU contribution
€ 698 875
Address
Carretera De Utrera Km 1
41013 Sevilla
Activity type
Higher or Secondary Education Establishments
FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V.
Germany
EU contribution
€ 927 848
Address
Ardeystrasse 67
44139 Dortmund
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 313 517
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
BETH ISRAEL DEACONESS MEDICAL CENTER, INC NON PROFIT CORPORATION
United States
EU contribution
€ 168 595
Address
Brookline Avenue 330
02105 Boston Ma
Activity type
Research Organisations
FONDAZIONE SANTA LUCIA
Italy
EU contribution
€ 867 500
Address
Via Ardeatina 306
00179 Roma
Activity type
Research Organisations