Digital twins for model-driven non-invasive electrical brain stimulation

Project Information

Neurotwin

Grant agreement ID: 101017716

DOI 10.3030/101017716

EC signature date 2 December 2020

Start date 1 January 2021

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 4 485 736,25

EU contribution € 4 485 735,00

Coordinated by

NEUROELECTRICS BARCELONA SL
Spain

Deliverables

Documents, reports (2)

Web and dissemination materials

Website project logo and dissemination materials

Cross-project collaboration plan

Updated each reporting period

Publications

Peer reviewed articles (5)

Complex spatiotemporal oscillations emerge from transverse instabilities in large-scale brain networks

Author(s): Pau Clusella; Gustavo Deco; Morten L. Kringelbach; Giulio Ruffini; Jordi Garcia-Ojalvo
Published in: PLOS Computational Biology, 2023, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1010781

Comparison between an exact and a heuristic neural mass model with second-order synapses

Author(s): Pau Clusella, Elif Köksal-Ersöz, Jordi Garcia-Ojalvo and Giulio Ruffini
Published in: Biological Cybernetics, 2022, ISSN 0340-1200
Publisher: Springer Verlag
DOI: 10.1007/s00422-022-00952-7

LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics

Author(s): Giulio Ruffini,Giada Damiani, Diego Lozano-Soldevilla, Nikolas Deco, Fernando E. Rosas, Narsis A. Kiani, Adrián Ponce-Alvarez, Morten L. Kringelbach, Robin Carhart-Harris, Gustavo Deco
Published in: Plos Computational Biology, 2023, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1010811

Dynamic sensitivity analysis: Defining personalised strategies to drive brain state transitions via whole brain modelling

Author(s): Jakub Vohryzek, Joana Cabral, Francesca Castaldo, Yonatan Sanz-Perl, Louis-David Lord, Henrique M. Fernandes, Vladimir Litvak, Morten L. Kringelbach, Gustavo Deco
Published in: Computational and Structural Biotechnology Journal, 2023, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2022.11.060

A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings

Author(s): Roser Sanchez-Todo; André M. Bastos; Edmundo Lopez Sola; Borja Mercadal; Emiliano Santarnecchi; Earl K. Miller; Gustavo Deco; Giulio Ruffini
Published in: NeuroImage, 2023, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2023.119938

Other (7)

Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice

Author(s): Carlos Andrés Sánchez-León, Guillermo Sánchez-Garrido Campos, Marta Fernández, Álvaro Sánchez-López, Javier F Medina, Javier Márquez-Ruiz
Published in: 2023
Publisher: bioRxiv
DOI: 10.1101/2023.02.18.529047

Spherical harmonics representation of the steady-state membrane potential shift induced by tDCS in realistic neuron models

Author(s): Adrià Galan-Gadea, Ricardo Salvador, Fabrice Bartolomei, Fabrice Wendling, Giulio Ruffini
Published in: 2022
Publisher: bioRxiv
DOI: 10.1101/2022.07.19.500653

Analysis and extension of exact mean-field theory with dynamic synaptic currents

Author(s): Giulio Ruffini
Published in: 2022
Publisher: bioRxiv
DOI: 10.1101/2021.09.01.458563

Regular and sparse neuronal synchronization are described by identical mean field dynamics

Author(s): Clusella, Pau; Montbrió, Ernest
Published in: 2022
Publisher: arxiv
DOI: 10.48550/arxiv.2208.05515

The 2D Ising model, criticality and AIT

Author(s): Giulio Ruffini and Gustavo Deco
Published in: 2021
Publisher: bioRxiv
DOI: 10.1101/2021.10.21.465265

Kuramoto model for populations of quadratic integrate-and-fire neurons with chemical and electrical coupling

Author(s): Pau Clusella; Bastian Pietras; Ernest Montbrió
Published in: 2021
Publisher: arxiv
DOI: 10.48550/arxiv.2110.07665

Design of effective personalised perturbation strategies for enhancing cognitive intervention in Alzheimer’s disease

Author(s): Jakub Vohryzek, Joana Cabral, Yonatan Sanz Perl, Murat Demirtas, Carles Falcon, Juan Domingo Gispert, Beatriz Bosch, Mircea Balasa, Morten Kringelbach, Raquel Sanchez-Valle, Giulio Ruffini, Gustavo Deco
Published in: 2023
Publisher: bioRxiv
DOI: 10.1101/2023.04.20.537688

Thesis and dissertations (1)

Validation and Refinement of a Laminar Neural Mass Model Using in vivo Mice Data

Author(s): Martina Moreno Fina, Pau Clusella Coberó, Roser Sánchez-Todo, and Jordi Soriano Fradera
Published in: 2023
Publisher: Universitat Politecnica de Catalunya

Conference proceedings (1)

TH-230. Mechanistic understanding of Alzheimer’s disease through hybrid brain models: from mesoscale to macroscale, and design of personalized stimulation protocols

Author(s): R Sanchez-Todo, EL Sola, R Salvador, MC Biagi, G Deco, G Ruffini
Published in: 2022
Publisher: Clinical Neurophysiology
DOI: 10.1016/j.clinph.2022.07.416