Combining optoacoustic imaging phenotypes and multi-omics to advance diabetes healthcare

Project Information

OPTOMICS

Grant agreement ID: 101017802

DOI

10.3030/101017802

EC signature date 16 December 2020

Start date 1 January 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost

€ 4 414 127,50

EU contribution

€ 4 414 126,55

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

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Deliverables

Websites, patent fillings, videos etc. (1)

Project web site, logo & social media

Project web site logo social media incl communication manuals and data repository

Publications

Peer reviewed articles (10)

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Author(s): Natalia Pervjakova, Gunn-Helen Moen, Maria-Carolina Borges, Teresa Ferreira, James P Cook, Catherine Allard, Robin N Beaumont, Mickaël Canouil, Gad Hatem, Anni Heiskala, Anni Joensuu, Ville Karhunen, Soo Heon Kwak, Frederick T J Lin, Jun Liu, Sheryl Rifas-Shiman, Claudia H Tam, Wing Hung Tam, Gudmar Thorleifsson, Toby Andrew, Juha Auvinen, Bishwajit Bhowmik, Amélie Bonnefond, Fabien Delahaye, Ay
Published in: Human Molecular Genetics, Issue Volume 31, Issue 19, 2022, Page(s) 3377–3391, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddac050

A primer on current status and future opportunities of clinical optoacoustic imaging

Author(s): Ferdinand Knieling, Serene Lee, Vasilis Ntziachristos
Published in: npj Imaging, Issue 3, 2025, ISSN 2948-197X
Publisher: Nature Portfolio
DOI: 10.1038/s44303-024-00065-9

Insights into the molecular underpinning of type 2 diabetes complications

Author(s): Archit Singh, Ozvan Bocher, Eleftheria Zeggini
Published in: Human Molecular Genetics, Issue 34, 2025, Page(s) 469-480, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddae203

Disentangling the consequences of type 2 diabetes on targeted metabolite profiles using causal inference and interaction QTL analyses

Author(s): Ozvan Bocher, Archit Singh, Yue Huang, Urmo Võsa, Ene Reimann, Ana Arruda, Andrei Barysenska, Anastassia Kolde, Nigel W. Rayner, null null, Tõnu Esko, Reedik Mägi, Eleftheria Zeggini
Published in: PLOS Genetics, Issue 20, 2024, Page(s) e1011346, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1011346

Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health

Author(s): Konstantinos Rouskas, Ozvan Bocher, Alexandros Simistiras, Christina Emmanouil, Panagiotis Mantas, Anargyros Skoulakis, Young-Chan Park, Alexandros Dimopoulos, Stavros Glentis, Gabi Kastenmüller, Eleftheria Zeggini, Antigone S. Dimas
Published in: npj Metabolic Health and Disease, Issue 3, 2025, ISSN 2948-2828
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44324-025-00057-2

Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction

Author(s): Ozvan Bocher, Arthur Gilly, Young-Chan Park, Eleftheria Zeggini, and Andrew P. Morris
Published in: Human Genetics and Genomics Advances, Issue 100214, 2023, ISSN 2666-2477
Publisher: Cell Press Elsevier Inc.
DOI: 10.1016/j.xhgg.2023.100214

Correcting for Genomic Inflation Leads to Loss of Power in Large‐Scale Genome‐Wide Association Study Meta‐Analysis

Author(s): Archit Singh, Lorraine Southam, Konstantinos Hatzikotoulas, Nigel W. Rayner, Ken Suzuki, Henry J. Taylor, Xianyong Yin, Ravi Mandla, Alicia Huerta‐Chagoya, Andrew P. Morris, Eleftheria Zeggini, Ozvan Bocher
Published in: Genetic Epidemiology, Issue 49, 2025, ISSN 0741-0395
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/gepi.70016

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Author(s): Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J. Taylor, Xianyong Yin, Kim M. Lorenz, Ravi Mandla, Alicia Huerta-Chagoya, Giorgio E. M. Melloni, Stavroula Kanoni, Nigel W. Rayner, Ozvan Bocher, Ana Luiza Arruda, Kyuto Sonehara, Shinichi Namba, Simon S. K. Lee, Michael H. Preuss, Lauren E. Petty, Philip Schroeder, Brett Vanderwerff, Mart Kals, Fiona Bragg, Kuang Lin, Xiuqing Guo,
Published in: Nature, 2024, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07019-6

Unravelling the genetic architecture of human complex traits through whole genome sequencing

Author(s): Ozvan Bocher, Cristen J. Willer & Eleftheria Zeggini
Published in: Nature Communications, Issue 14, 3520, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39259-x

Raster Scan Optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review

Author(s): Dimitrios Pantazopoulos, Evanthia Gouveri, Vasilis Ntziachristos, Nikolaos Papanas
Published in: Diabetes Research and Clinical Practice, Issue 222, 2025, Page(s) 112095, ISSN 0168-8227
Publisher: Elsevier BV
DOI: 10.1016/j.diabres.2025.112095