Understanding the functions of the BRCA protein complexes in DNA break repair and in replication stress

Project Information

BRCA INSIGHTS

Grant agreement ID: 101018257

DOI

10.3030/101018257

EC signature date 3 June 2021

Start date 1 April 2022

End date 31 March 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 868 152,50

EU contribution

€ 1 868 152,50

Coordinated by

FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Data and metadata generated by this project will be deposited in a research data repository and exploitable scientific results will be published

Publications

Peer reviewed articles (13)

Structure and repair of replication-coupled DNA breaks

Author(s): Raphael Pavani, Veenu Tripathi, Kyle B. Vrtis, Dali Zong, Raj Chari, Elsa Callen, Ajith V. Pankajam, Gang Zhen, Gabriel Matos-Rodrigues, Jiajie Yang, Shuheng Wu, Giordano Reginato, Wei Wu, Petr Cejka, Johannes C. Walter, André Nussenzweig
Published in: Science, Issue 385, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.ado3867

Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination

Author(s): Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S. Symington, Petr Cejka, Boris Pfander
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46951-z

WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures

Author(s): Mengoli V, Ceppi I, Sanchez A, Cannavo E, Halder S, Scaglione S, Gaillard PH, McHugh PJ, Riesen N, Pettazzoni P, Cejka P
Published in: EMBO J, Issue 42(3): e111998, 2023, ISSN 1460-2075
Publisher: EMBO press
DOI: 10.15252/embj.2022111998

MRN–CtIP, EXO1, and DNA2–WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage

Author(s): Isabelle M. Seppa, Ilaria Ceppi, Mithila Tennakoon, Giordano Reginato, Jessica Jackson, Celia D. Rouault, Sumedha Agashe, Vladislav O. Sviderskiy, Mangsi Limbu, Erica Lantelme, Alice Meroni, Stefan Braunshier, Damiano Borrello, Priyanka Verma, Petr Cejka, Alessandro Vindigni
Published in: Genes & Development, 2025, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.352421.124

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms

Author(s): Tomoki Tamai, Giordano Reginato, Ryusei Ojiri, Issei Morita, Alexandra Avrutis, Petr Cejka, Miki Shinohara, Katsunori Sugimoto
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51493-5

Mechanism of DNA unwinding by MCM8-9 in complex with HROB

Author(s): Ananya Acharya, Hélène Bret, Jen-Wei Huang, Martin Mütze, Martin Göse, Vera Maria Kissling, Ralf Seidel, Alberto Ciccia, Raphaël Guérois, Petr Cejka
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47936-8

Xrs2/NBS1 promote end-bridging activity of the MRE11-RAD50 complex

Author(s): Carl Möller, Rajhans Sharma, Robin Öz, Giordano Reginato, Elda Cannavo, Ilaria Ceppi, K.K. Sriram, Petr Cejka, Fredrik Westerlund
Published in: Biochemical and Biophysical Research Communications, Issue 695, 2024, Page(s) 149464, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2023.149464

Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection

Author(s): Ilaria Ceppi, Maria Rosaria Dello Stritto, Martin Mütze, Stefan Braunshier, Valentina Mengoli, Giordano Reginato, Hồ Mỹ Phúc Võ, Sonia Jimeno, Ananya Acharya, Megha Roy, Aurore Sanchez, Swagata Halder, Sean Michael Howard, Raphaël Guérois, Pablo Huertas, Sylvie M. Noordermeer, Ralf Seidel, Petr Cejka
Published in: Nature, Issue 634, 2024, Page(s) 492-500, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07909-9

PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection

Author(s): Ilaria Ceppi; Elda Cannavo; Hélène Bret; Rosa Camarillo; Francesca Vivalda; Roshan Singh Thakur; Amador Romero-Franco; Alessandro A. Sartori; Pablo Huertas; Raphaël Guérois; Petr Cejka
Published in: Genes & Development, 37 (3-4), Issue 37(3-4), 2023, Page(s) 119-135, ISSN 1549-5477
Publisher: Cold Spings Harbor Laboratory Press
DOI: 10.1101/gad.349981.122

Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP

Author(s): Yoann Nicolas, Hélène Bret, Elda Cannavo, Ananya Acharya, Petr Cejka, Valérie Borde, Raphaël Guerois
Published in: Molecular Cell, Issue 84, 2024, Page(s) 2223-2237.e4, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.05.019

HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability

Author(s): Gongshi Bai, Theresa Endres, Ulrike Kühbacher, Valentina Mengoli, Briana H. Greer, Emma M. Peacock, Matthew D. Newton, Tyler Stanage, Maria Rosaria Dello Stritto, Roxana Lungu, Magdalena P. Crossley, Ataya Sathirachinda, David Cortez, Simon J. Boulton, Petr Cejka, Brandt F. Eichman, Karlene A. Cimprich
Published in: Molecular Cell, Issue 84, 2024, Page(s) 3044-3060.e11, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.07.018

HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing

Author(s): Giordano Reginato, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, Vincent Morin, Elda Cannavo, Ilaria Ceppi, Stefan Braunshier, Ananya Acharya, Virginie Ropars, Jean-Baptiste Charbonnier, Martin Jinek, Andrè Nussenzweig, Taekjip Ha, Petr Cejka
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50080-y

Mechanisms and regulation of DNA end resection in the maintenance of genome stability

Author(s): Raphael Ceccaldi, Petr Cejka
Published in: Nature Reviews Molecular Cell Biology, 2025, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-025-00841-4