Understanding the pan-immune system of bacteria

Project Information

DefenseAgainstPhage

Grant agreement ID: 101018520

DOI

10.3030/101018520

EC signature date 21 August 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

An expanded arsenal of immune systems that protect bacteria from phages

Author(s): Adi Millman, Sarah Melamed, Azita Leavitt, Shany Doron, Aude Bernheim, Jens Hör, Jeremy Garb, Nathalie Bechon, Alexander Brandis, Anna Lopatina, Gal Ofir, Dina Hochhauser, Avigail Stokar-Avihail, Nitzan Tal, Saar Sharir, Maya Voichek, Zohar Erez, Jose Lorenzo M. Ferrer, Daniel Dar, Assaf Kacen, Gil Amitai, Rotem Sorek
Published in: Cell Host & Microbe, Issue 30(11), 2022, Page(s) 1556-1569e5, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2022.09.017

Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly

Author(s): Jens Hör, Sharon G. Wolf, Rotem Sorek
Published in: Nature, Issue 631, 2024, Page(s) 850-856, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07616-5

The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products

Author(s): Jeremy Garb, Gil Amitai, Allen Lu, Gal Ofir, Alexander Brandis, Tevie Mehlman, Philip J. Kranzusch, Rotem Sorek
Published in: PLOS ONE, Issue 19, 2024, Page(s) e0302251, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0302251

A conserved family of immune effectors cleaves cellular ATP upon viral infection

Author(s): Francois Rousset, Erez Yirmiya, Shahar Nesher, Alexander Brandis, Tevie Mehlman, Maxim Itkin, Sergey Malitsky, Adi Millman, Sarah Melamed, Rotem Sorek
Published in: Cell, Issue 186, 2023, Page(s) 3619-3631.e13, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.07.020

Phages overcome bacterial immunity via diverse anti-defence proteins

Author(s): Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E. Ragucci, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P. Antine, Sarah E. Mooney, Samuel J. Hobbs, Philip J. Kranzusch, Gil Amitai, Rotem Sorek
Published in: Nature, Issue 625, 2024, Page(s) 352-359, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06869-w

Bacterial origins of human cell-autonomous innate immune mechanisms

Author(s): Tanita Wein & Rotem Sorek
Published in: Nature Reviews. Immunology, Issue 22(10), 2022, Page(s) 629–638, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-022-00705-4

Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion

Author(s): Jeremy Garb, Anna Lopatina, Aude Bernheim, Mindaugas Zaremba, Virginijus Siksnys, Sarah Melamed, Azita Leavitt, Adi Millman, Gil Amitai and Rotem Sorek
Published in: Nature Microbiology, Issue 7, 2022, Page(s) 1849–1856, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-022-01207-8

Discovery of phage determinants that confer sensitivity to bacterial immune systems

Author(s): Avigail Stokar-Avihail, Taya Fedorenko, Jens Hör, Jeremy Garb, Azita Leavitt, Adi Millman, Gabriela Shulman, Nicole Wojtania, Sarah Melamed, Gil Amitai, Rotem Sorek
Published in: Cell, Issue 186(9), 2023, Page(s) 1863-1876, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.02.029

The defense island repertoire of the Escherichia coli pan-genome

Author(s): Dina Hochhauser, Adi Millman, Rotem Sorek
Published in: PLoS Genetics, Issue 19(4), 2023, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1010694

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

Author(s): Samuel J Hobbs, Tanita Wein, Allen Lu, Benjamin R Morehouse, Julia Schnabel, Azita Leavitt, Erez Yirmiya, Rotem Sorek and Philip J Kranzusch
Published in: Nature, Issue 605(7910), 2022, Page(s) 522-526, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04716-y

SnapShot: Bacterial immunity

Author(s): Nitzan Tal and Rotem Sorek
Published in: Cell, Issue 185(3), 2022, Page(s) 578-578.e1, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.12.029

The evolutionary success of regulated cell death in bacterial immunity

Author(s): Francois Rousset and Rotem Sorek
Published in: Current Opinion in Microbiology, Issue 74, 2022, ISSN 1879-0364
Publisher: Elsevier
DOI: 10.1016/j.mib.2023.102312

Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

Author(s): Azita Leavitt, Erez Yirmiya, Gil Amitai, Allen Lu, Jeremy Garb, Ehud Herbst, Benjamin R. Morehouse, Samuel J. Hobbs, Sadie P. Antine, Zhen-Yu J. Sun, Philip J. Kranzusch and Rotem Sorek
Published in: Nature, Issue 611(7935), 2022, Page(s) 326–331, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05375-9