molecular and functional characterization of EmergiNG INflammasomES

Project Information

ENGINES

Grant agreement ID: 101018672

DOI

10.3030/101018672

EC signature date 13 August 2021

Start date 1 September 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 372 637,00

EU contribution

€ 2 372 637,00

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Friendly fire: recognition of self by the innate immune system

Author(s): Veit Hornung, Moritz M Gaidt
Published in: Current Opinion in Immunology, Issue 90, 2024, Page(s) 102457, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2024.102457

Stimulator of Interferon Genes Ablation in T Cells Is Required for the Efficacy of Stimulator of Interferon Genes Agonists in Chimeric Antigen Receptor-T Cell Immunotherapy of Pancreatic Cancer

Author(s): Ignazio Piseddu, Rebekka Endres, Fabian Lanzl, Linda Hammann, Marleen Bérouti, Matthias Thaler, Lisa Fahr, Hannah Fischer, Varvara Varlamova, Jan Gärtig, Daniel Nixdorf, Patrick Layritz, Charlotte Marx, Christine Hörth, Catharina Witte, Alpay Bulut, David Illig, Anne Marie Senz, Lesca Holdt, Ivonne Regel, Adrian Gottschlich, Marion Subklewe, Julia Mayerle, David Anz, Sebastian Kobold, Andreas L
Published in: Gastroenterology, 2026, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2026.01.031

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

Author(s): Niklas A. Schmacke, Fionan O'Duill, Moritz M. Gaidt, Inga Szymanska, Julia M. Kamper, Jonathan L. Schmid-Burgk, Sophia C. Mädler, Timur Mackens-Kiani, Tatsuya Kozaki, Dhruv Chauhan, Dennis Nagl, Che A. Stafford, Hartmann Harz, Adrian L. Fröhlich, Francesca Pinci, Florent Ginhoux, Roland Beckmann, Matthias Mann, Heinrich Leonhardt & Veit Hornung
Published in: Immunity, Issue 55(12), 2022, Page(s) 2271-2284, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.10.021

Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus

Author(s): Stefan Bauernfried, Tobias Komar, Katja Sterle, Maria C. Tanzer, Alexander R. Horswill, Matthias Mann, Veit Hornung
Published in: Journal of Biological Chemistry, Issue 301, 2026, Page(s) 110574, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.110574

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Author(s): Marleen Bérouti, Mirko Wagner, Wilhelm Greulich, Ignazio Piseddu, Jan Gärtig, Larissa Hansbauer, Christoph Müller-Hermes, Matthias Heiss, Alexander Pichler, Annika J. Tölke, Gregor Witte, Karl-Peter Hopfner, David Anz, Michael Sattler, Thomas Carell, Veit Hornung
Published in: Cell, Issue 188, 2026, Page(s) 4880-4895.e15, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.05.032

Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9

Author(s): Wolf, Christine; Fischer, Hannah; Kühl, Jörn-Sven; Koss, Sarah; Jamra, Rami Abou; Starke, Sven; Schultz, Jurek; Ehl, Stephan; Neumann, Katrin; Schuetz, Catharina; Huber, Robert; Hornung, Veit; Lee-Kirsch, Min Ae
Published in: The Journal of allergy and clinical immunology, 2023, ISSN 1097-6825
Publisher: Elsevier
DOI: 10.1016/j.jaci.2023.07.013

Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

Author(s): Che A. Stafford, Alicia-Marie Gassauer, Carina C. de Oliveira Mann, Maria C. Tanzer, Evelyn Fessler, Benedikt Wefers, Dennis Nagl, Gunnar Kuut, Karolina Sulek, Catherine Vasilopoulou, Sophia J. Schwojer, Andreas Wiest, Marie K. Pfautsch, Wolfgang Wurst, Monica Yabal, Thomas Fröhlich, Matthias Mann, Nicolas Gisch, Lucas T. Jae & Veit Hornung
Published in: Nature, Issue 609, 2022, Page(s) 590–596, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/s41586-022-05125-x

Vaccinia virus F1L blocks the ribotoxic stress response to subvert ZAKα‐dependent NLRP1 inflammasome activation

Author(s): Inga Szymanska, Stefan Bauernfried, Tobias Komar, Veit Hornung
Published in: European Journal of Immunology, 2024, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202451135

Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation

Author(s): Marleen Bérouti, Katja Lammens, Matthias Heiss, Larissa Hansbauer, Stefan Bauernfried, Jan Stöckl, Francesca Pinci, Ignazio Piseddu, Wilhelm Greulich, Meiyue Wang, Christophe Jung, Thomas Fröhlich, Thomas Carell, Karl-Peter Hopfner, Veit Hornung
Published in: Immunity, Issue 57, 2024, Page(s) 1482-1496.e8, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2024.04.010

RNase T2 restricts TLR13-mediated autoinflammation in vivo

Author(s): Carlos Gomez-Diaz, Wilhelm Greulich, Benedikt Wefers, Meiyue Wang, Silvia Bolsega, Maike Effern, Daniel P. Varga, Zhe Han, Minyi Chen, Marleen Bérouti, Natascia Leonardi, Ulrike Schillinger, Bernhard Holzmann, Arthur Liesz, Axel Roers, Michael Hölzel, Marijana Basic, Wolfgang Wurst, Veit Hornung
Published in: Journal of Experimental Medicine, Issue 222, 2025, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20241424

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

Author(s): Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek Chian Tham, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Celest W. S. Tay, Kiat Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Sobota, John E. Connolly, John Common, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Bin Wu, Veit Hornung &
Published in: Science, Issue 377, 2022, Page(s) 328-335, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abl6324

Non-peer reviewed articles (2)

A critical role for palmitoylation in pyroptosis

Author(s): Zhiqi Sun, Veit Hornung
Published in: Molecular Cell, Issue 84, 2024, Page(s) 2218-2220, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.05.023

Human NLRP1: From the shadows to center stage

Author(s): Stefan Bauernfried; Veit Hornung
Published in: Journal of Experimental Medicine, Issue 219, 2022, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20211405