Gut epithelial dynamics and function at the nexus of early life infection and long-term health

Project Information

EarlyLife

Grant agreement ID: 101019157

DOI

10.3030/101019157

EC signature date 8 July 2021

Start date 1 August 2021

End date 31 July 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 450 000,00

EU contribution

€ 2 450 000,00

Coordinated by

UNIVERSITAETSKLINIKUM AACHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Other (1)

Developmental factors drive the compartmentalised and discontinuous maturation of the small intestinal epithelium during the early postnatal period

Author(s): Johannes Schöneich, Aline Dupont, Stefan Schlößer, Matthias A. Schmitz, Isabel Richter, Narasimha Murthy Keshava Prasad Gubbi, Mingbo Cheng, Tiago Maié, Sofia Jäverfelt, Fabian Imdahl, Christophe Toussaint, Antoine-Emmanuel Saliba, Christoph Kuppe, Thaher Pelaseyed, Ivan G. Costa, Mathias W. Hornef
Published in: preprint repository, bioRxiv, 2026
Publisher: bioRxiv
DOI: 10.1101/2025.05.15.654215

Peer reviewed articles (6)

Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host

Author(s): Kaiyi Zhang, Urska Repnik, Nour Diab, Daniel Friske, Andreas Pütz, Alina Z Bachmann, Narasimha Murthy Keshava Prasad Gubbi, Michael Hensel, Konrad U Förstner, Alexander J Westermann, Aline Dupont, Mathias W Hornef
Published in: Journal of Experimental Medicine, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20231237

M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch

Author(s): Natalia Torow, Ronghui Li, Thomas Charles Adrian Hitch, Clemens Mingels, Shahed Al Bounny, Niels van Best, Eva-Lena Stange, Britta Simons, Tiago Maié, Lennart Rüttger, Narasimha Murthy Keshava Prasad Gubbi, Darryl Adelaide Abbott, Adam Benabid, Michael Gadermayr, Solveig Runge , Nicole Treichel, Dorit Merhof, Stephan Patrick Rosshart, Nico Jehmlich, Timothy Wesley Hand, Martin von Bergen, Felix
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.04.002

<i>Salmonella</i> infection accelerates postnatal maturation of the intestinal epithelium

Author(s): Stefan Schlößer, Anna-Lena Ullrich, Nastaran Fazel Modares, Matthias A. Schmitz, Johannes Schöneich, Kaiyi Zhang, Isabel Richter, Laura Robrahn, Sarah Schraven, James S. Nagai, Sven-Bastiaan Haange, Susan A. V. Jennings, Thomas Clavel, Ulrike Rolle-Kampczyk, Fabian Kiessling, Ivan G. Costa, Vanesa Muncan, Urska Repnik, Martin von Bergen, Aline Dupont, Mathias W. Hornef
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2403344122

Programmed and environmental determinants driving neonatal mucosal immune development

Author(s): Natalia Torow, Timothy Hand, Mathias Hornef
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.02.013

Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes

Author(s): Mangge Zou, Joern Pezoldt, Juliane Mohr, Lars Philipsen, Andrea Leufgen, Vuk Cerovic, Carolin Wiechers, Marina Pils, Diego Ortiz, Lianxu Hao, Juhao Yang, Michael Beckstette, Aline Dupont, Mathias Hornef, Petra Dersch, Till Strowig, Andreas J. Müller, Jens Raila, Jochen Huehn
Published in: Cell Reports, Issue 43, 2024, Page(s) 114153, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2024.114153

Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies

Author(s): Katherine M. Kennedy, Marcus C. de Goffau, Maria Elisa Perez-Muñoz6, Marie-Claire Arrieta, Fredrik Bäckhed, Peer Bork, Thorsten Braun, Frederic D. Bushman, Joel Dore, Willem M. de Vos, Ashlee M. Earl, Jonathan A. Eisen, Michal A. Elovitz, Stephanie C. Ganal-Vonarburg, Michael G. Gänzle, Wendy S. Garrett, Lindsay J. Hall, Mathias W. Hornef, Curtis Huttenhower, Liza Konnikova, Sarah Lebeer, Andre
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41586-022-05546-8

Non-peer reviewed articles (2)

On microbial syringes: Advances in our understanding of type III secretion systems in bacterial pathogenesis

Author(s): Mathias W. Hornef, Jonathan Jantsch
Published in: Physics of Life Reviews, Issue 39, 2025, Page(s) 96-98, ISSN 1571-0645
Publisher: Elsevier BV
DOI: 10.1016/j.plrev.2021.07.003

EarlyLife - Gut epithelial dynamics and function at the nexus of early life infection and longterm health

Author(s): null null, Mathias Hornef
Published in: EU Research, Issue Autumn 2024, 2024, Page(s) 18-19, ISSN 2752-4728
Publisher: EU Research
DOI: 10.56181//jmgh1344