Custom-designed gene editing of induced epidermal stem cells for gene therapy of genetic diseases of squamous epithelia

Project Information

Holo-GT

Grant agreement ID: 101019289

DOI

10.3030/101019289

EC signature date 5 July 2021

Start date 1 September 2021

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 462 375,00

EU contribution

€ 2 462 375,00

Coordinated by

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

Data Management Plan DMP

Publications

Peer reviewed articles (5)

Biochemical role of FOXM1-dependent histone linker H1B in human epidermal stem cells

Author(s): Maria Pia Polito, Grazia Marini, Alessandra Fabrizi, Laura Sercia, Elena Enzo, Michele De Luca
Published in: Cell Death & Disease, Issue 15, 2024, Page(s) 15, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-024-06905-1

Allele-specific CRISPR-Cas9 editing of dominant epidermolysis bullosa simplex in human epidermal stem cells

Author(s): C. Cattaneo, E. Enzo, L. De Rosa, L. Sercia, F. Consiglio, M. Forcato, S. Bicciato, A. Paiardini, G. Basso, E. Tagliafico, A. Paganelli, C. Fiorentini, C. Magnoni, M.C. Latella, M. De Luca
Published in: Molecular Therapy, Issue 32, 2024, Page(s) 372-383, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2023.11.027

Stairways to Advanced Therapies for Epidermolysis Bullosa.

Author(s): Laura De Rosa, Elena Enzo , Michele Palamenghi, Laura Sercia, Michele De Luca
Published in: Cold Spring Harb Perspect Biol ., 2023, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041229

A cellular disease model toward gene therapy of TGM1-dependent lamellar ichthyosis

Author(s): Laura Sercia, Oriana Romano, Grazia Marini, Elena Enzo, Mattia Forcato, Laura De Rosa, Michele De Luca
Published in: Molecular Therapy - Methods & Clinical Development, Issue 32, 2024, Page(s) 101311, ISSN 2329-0501
Publisher: ASGCT
DOI: 10.1016/j.omtm.2024.101311

AlPaCas: allele-specific CRISPR gene editing through a protospacer-adjacent-motif (PAM) approach

Author(s): Serena Rosignoli, Elisa Lustrino, Alessio Conci, Alessandra Fabrizi, Serena Rinaldo, Maria Carmela Latella, Elena Enzo, Gianni Prosseda, Laura De Rosa, Michele De Luca, Alessandro Paiardini
Published in: Nucleic Acid Research, 2024, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae419