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Social inequalities in population health: integrating evidence from longitudinal, family-based and genetically informed data

Descripción del proyecto

Una perspectiva diferente de las desigualdades sanitarias

Los ingresos y el estatus social determinan la salud de manera significativa. La pobreza está relacionada con peores resultados sanitarios: en la actualidad, se espera que las personas con bajos ingresos vivan entre cinco y diez años menos que quienes se encuentren en mejores condiciones. En el proyecto HEALTHINEQ, financiado con fondos europeos, se investigarán los factores que propician los cambios a largo plazo en las desigualdades sanitarias, centrándose en el papel de la familia y otros factores socioeconómicos. Además, se explorarán las interdependencias multigeneracionales de la posición social y la salud en hasta cuatro generaciones y se empleará información genética molecular para analizar si las asociaciones genéticas están mediadas. Los hallazgos arrojarán luz sobre cómo los factores familiares y genéticos se entrelazan con las características sociales individuales y cómo se manifiestan en los resultados sanitarios en diferentes condiciones sociales a nivel macro.

Objetivo

Social inequalities in health are observed in all societies. These inequalities have grown markedly over the past 30 years, with those in less advantaged social positions currently expected to live 5–10 years less than those in more advantaged positions. The study aims to establish the root causes of these inequalities by (1) assessing the drivers of long-term changes in health inequalities and establishing the contribution of family factors and macro-level social and economic conditions to these changes; (2) examining multigenerational interdependencies of social position and health in up to four generations; (3) estimating the causal effects of social position on health by employing molecular genetic information and assessing whether genetic associations are mediated or modified by social position; (4) evaluating the generalisability of explanations of social inequalities in health through international comparative research. The study will integrate research scattered in multiple disciplines by establishing how family background – both social as experienced through living conditions and social resources in families, and genetic as inherited from biological parents – affects health and social disadvantage within and across generations. The project will go beyond standard observational research through new conceptual insight and by using a unique combination of longitudinal register-based and genetically informed data sources. We will take advantage of natural experiments – educational and alcohol policy reforms and rapid economic changes – to identify pivotal social processes in the production of health inequalities. Our results will be ground-breaking because we will establish how family and genetic factors are intertwined with individual social characteristics and how they manifest in health outcomes in different macro-level social conditions. The power to test causal hypotheses will advance science and help devise policies to reduce health inequalities.

Régimen de financiación

ERC-ADG - Advanced Grant

Institución de acogida

HELSINGIN YLIOPISTO
Aportación neta de la UEn
€ 2 499 422,00
Dirección
YLIOPISTONKATU 3
00014 Helsingin Yliopisto
Finlandia

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Región
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 2 499 422,50

Beneficiarios (1)