Understanding and controlling the spatial organisation of cancer

Información del proyecto

CAN_ORGANISE

Identificador del acuerdo de subvención: 101019366

DOI

10.3030/101019366

Fecha de la firma de la CE 14 Septiembre 2021

Fecha de inicio 1 Octubre 2021

Fecha de finalización 31 Marzo 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Periodic Reporting for period 2 - CAN_ORGANISE (Understanding and controlling the spatial organisation of cancer)

Período documentado: 2023-04-01 hasta 2024-09-30

Resumen del contexto y de los objetivos generales del proyecto

The project CAN_ORGANISE seeks to understand the spatial organisation of tumours. This is important because cancer is one of the leading causes of mortality across the world and 1 in 2 people in Europe will have cancer in their lifetime. How tumours are organised is linked to their ability to spread through the body and how they respond to treatment. In this work, we want to change how tumours are organised to make them less dangerous and easier to treat.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

We have set up new mathematical ways of measuring patterns in space in tumours. To try to control the patterns in tumours, we have set up a new method for studying cancer patterns in a dish. This is helping us to understand how tumours keep out the body’s defence cells (T-cells). We have now found out how to let these cells in, and are testing if this helps to treat tumours.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Our new methods and tools will enable new ways of changing how tumours are organised to be discovered. In particular, we expect to find new 'gene switches' that change the spatial organisation of tumours. These will be good targets for developing new drugs to improve the treatment of cancer.