Understanding the mechanical control of cell extrusion in collective assemblies

Project Information

DeadorAlive

Grant agreement ID: 101019835

DOI

10.3030/101019835

EC signature date 19 July 2021

Start date 1 December 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 000,00

EU contribution

€ 2 499 000,00

Coordinated by

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Force transmission is a master regulator of mechanical cell competition

Author(s): Andreas Schoenit, Siavash Monfared, Lucas Anger, Carine Rosse, Varun Venkatesh, Lakshmi Balasubramaniam, Elisabetta Marangoni, Philippe Chavrier, René-Marc Mège, Amin Doostmohammadi, Benoit Ladoux
Published in: Nature Materials, Issue 24, 2025, Page(s) 966-976, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-025-02150-9

Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation

Author(s): Takumi Kawaue, Ivan Yow, Yuping Pan, Anh Phuong Le, Yuting Lou, Mavis Loberas, Murat Shagirov, Xiang Teng, Jacques Prost, Tetsuya Hiraiwa, Benoit Ladoux, Yusuke Toyama
Published in: Developmental Cell, Issue Feb 27;58(4), 2023, Page(s) 267-277, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2023.01.005

A minimal physical model for curvotaxis driven by curved protein complexes at the cell’s leading edge

Author(s): Raj Kumar Sadhu; Marine Luciano; Wang Xi; Cristina Martinez-Torres; Marcel Schröder; Christoph Blum; Marco Tarantola; Stefano Villa; Samo Penič; Aleš Iglič; Carsten Beta; Oliver Steinbock; Eberhard Bodenschatz; Benoît Ladoux; Sylvain Gabriele; Nir S. Gov
Published in: Proceedings of the National Academy of Sciences USA, Issue 2, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2306818121

Mechanical stress driven by rigidity sensing governs epithelial stability

Author(s): S. Sonam, L. Balasubramaniam, S-Z. Lin, I. Yow, I. P. Jauma, C. Jebane, M. Karnat, Y. Toyama, P. Marcq, J. Prost, R-M. Mège, J-F. Rupprecht, B. Ladoux
Published in: Nature Physics, 2023, Page(s) 132–141, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-022-01826-2

Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density

Author(s): Julia Eckert, Benoît Ladoux, René-Marc Mège, Luca Giomi, Thomas Schmidt
Published in: Nature Communications, Issue 14, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41449-6

Flocking and giant fluctuations in epithelial active solids

Author(s): Yuan Shen, Jérémy O’Byrne, Andreas Schoenit, Ananyo Maitra, René-Marc Mège, Raphaël Voituriez, Benoit Ladoux
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2421327122

Capturing nematic order on tissue surfaces of arbitrary geometry

Author(s): Julia Eckert, Toby G. R. Andrews, Joseph Pollard, Yuan Shen, Patricia Essebier, Benoit Ladoux, Anne K. Lagendijk, Rashmi Priya, Alpha S. Yap, Richard G. Morris
Published in: Nature Communications, Issue 16, 2025, Page(s) 7596, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-62694-x

Dynamic forces shape the survival fate of eliminated cells

Author(s): Lakshmi Balasubramaniam, Siavash Monfared, Aleksandra Ardaševa, Carine Rosse, Andreas Schoenit, Tien Dang, Chrystelle Maric, Mathieu Hautefeuille, Leyla Kocgozlu, Ranjith Chilupuri, Sushil Dubey, Eli
Published in: Nature Physics, Issue 21, 2025, Page(s) 269-278, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-024-02716-5

Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion

Author(s): Lakshmi Balasubramaniam, Shreyansh Jain, Tien Dang, Emilie Lagoutte, René Marc Mège, Philippe Chavrier, Benoit Ladoux, Carine Rossé
Published in: Advanced Science, Issue 11, 2025, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202401573

The emergence of spontaneous coordinated 3D epithelial rotation on curved surfaces

Author(s): A Glentis, C Blanch-Mercader, L Balasubramaniam, T.B. Saw, J d’Alessandro, S Janel, A Douanier, B. Delaval, F. Lafont, C. T. Lim, D. Delacour, J. Prost, W. Xi, B. Ladoux
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abn5406