Impact
Impact on the researcher's career. The work undertaken by the researcher was done with constant support from the supervisor – through day-to-day contact, and a series of professional development and training exercises. In the Weekly group meeting, usually two members of the group present their work over the previous 3-4 months to the whole group by PowerPoint presentation (develops presentation skills of the researcher). In the weekly group meetings alternating literature discussion / problem solving on the whiteboard (improves chemistry knowledge and informal presentation skills of the researcher) at the host institution. This gave him the opportunity to be fully dedicated to his project, whilst expanding his knowledge in chemistry. Overall, the researcher benefited from a thorough training in modern organic chemistry – from theoretical knowledge to practical aspects – in a university of excellence. This was only possible thanks to the comfort provided by this prestigious fellowship, which facilitated the daily work of the researcher in the laboratory – by giving him enough funds to order consumables and chemicals. Overall, this postdoctoral position greatly enhanced the career prospects of the researcher and helped him to find another postdoctoral position at the Max Planck Institute of Chemical Energy Conversion at the Mulheim an der Ruhr, Germany, under the direction of Prof. Walter Leitner (director in molecular catalysis). He will transfer the knowledge he gained during his Marie-Curie postdoctoral position at the University of Oxford to his current study.
Project’s Impact. The synthesis of deuterium labelled bicyclopentane (BCP) drug analogues and their application in mechanistic study and in biological system (in collaboration with other research group) are the current goal which could open-up new window in the research of propellane chemistry. We developed the synthetic route of the [1.1.1]propellane-dn (n = 2, 4, and 6) thus giving an opportunity to another researcher to work on this project within the group and, some publications are anticipated. One publication was published (Org. Lett. 2024, 26, 284) where the researcher is as a co-author and another publication will come from the journal Nature Protocols (under minor revision) soon on ‘Synthesis of bicyclo[3.1.1]heptanes meta-substituted arene bioisosteres, from [3.1.1]propellane’ where the researcher is as a first author.
Update of the plan for exploitation and dissemination of results. One publication as a co-author (Org. Lett. 2024, 26, 284) was published on the ‘Synthesis of Heterocycle-Substituted Bicyclo[3.1.1]heptanes and Aza-bicyclo[3.1.1]heptanes via Photocatalytic Minisci Reaction’. A second paper as a first author is now under revision (minor) in the journal Nature Protocols on ‘Synthesis of bicyclo[3.1.1]heptanes meta-substituted arene bioisosteres, from [3.1.1]propellane’. Further work need to be done to explore the deuterium labelled and aryl substituted [1.1.1]propellane chemistry, and publications are anticipated. Throughout the Fellowship, the researcher was encouraged to participate in ongoing Outreach activities within the Chemistry Department, such as the Department Open Day, which includes tours of the various laboratories. The Host group also uses a Lay Summary (includes the topics of the Fellow's research) on the group website to provide comprehensible information on group research to the general public. These publications acknowledge EU funding including the specific grant code (101020227) of the Fellowship.
