Transcriptional Adaptation and Genetic Compensation

Project Information

TAaGC

Grant agreement ID: 101021349

DOI

10.3030/101021349

EC signature date 10 July 2021

Start date 1 January 2022

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

Parental mutations influence wild-type offspring via transcriptional adaptation

Author(s): Zhen Jiang, Mohamed A El-Brolosy, Vahan Serobyan, Jordan M Welker, Nicholas Retzer, Christopher M Dooley, Gabrielius Jakutis, Thomas Juan, Nana Fukuda, Hans-Martin Maischein, Darius Balciunas, Didier Y R Stainier
Published in: Science Advances, Issue 8, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science - AAAS
DOI: 10.1126/sciadv.abj2029

Transcriptional adaptation: where mRNA decay meets genetic compensation

Author(s): Lara Falcucci, Brian Juvik, Didier YR Stainier
Published in: Current Opinion in Genetics & Development, Issue 93, 2026, Page(s) 102369, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2025.102369

A new hypothesis to explain disease dominance

Author(s): Brian Juvik, Lara Falcucci, Pia R. Lundegaard, Didier Y.R. Stainier
Published in: Trends in Genetics, 2025, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2024.11.009

Partial sequence identity in a 25-nucleotide long element is sufficient for transcriptional adaptation in the Caenorhabditis elegans act-5/act-3 model

Author(s): Jordan M. Welker, Vahan Serobyan, Elhamalsadat Zaker Esfahani, Didier Y. R. Stainier
Published in: PLoS Genetics, Issue 19, 2023, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1010806

A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish

Author(s): Samuel J. Capon, Anastasia Maroufidou, McKenna Feltes, Yanli Xu, Darpan Kaur Matharoo, Dörthe Jülich, Scott A. Holley, Steven A. Farber, Didier Y. R. Stainier
Published in: PLOS Genetics, Issue 21, 2025, Page(s) e1011747, ISSN 1553-7404
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgen.1011747

The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration

Author(s): Pinelopi Goumenaki, Stefan Günther, Khrievono Kikhi, Mario Looso, Rubén Marín-Juez, Didier Y. R. Stainier
Published in: Nature Cardiovascular Research, Issue 3, 2024, Page(s) 1158-1176, ISSN 2731-0590
Publisher: Nature Portfolio - Springer Nature
DOI: 10.1038/s44161-024-00538-5

Induction of a transcriptional adaptation response by RNA destabilization events

Author(s): Lihan Xie, Gabrielius Jakutis, Christopher M Dooley, Stefan Guenther, Zacharias Kontarakis, Sarah P Howard, Thomas Juan, Didier Y R Stainier
Published in: EMBO Reports, Issue 26, 2026, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.1038/s44319-025-00427-3

<i>egr3</i> is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis

Author(s): Agatha Ribeiro da Silva, Felix Gunawan, Giulia L. M. Boezio, Emilie Faure, Alexis Théron, Jean-François Avierinos, SoEun Lim, Shivam Govind Jha, Radhan Ramadass, Stefan Guenther, Mario Looso, Stéphane Zaffran, Thomas Juan, Didier Y. R. Stainier
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science's (AAAS)
DOI: 10.1126/sciadv.adl0633

A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish

Author(s): Thomas Juan, Tonatiuh Molina, Lihan Xie, Sofia Papadopoulou, Bárbara Cardoso, Shivam Govind Jha, Didier Y.R. Stainier
Published in: PLOS Genetics, Issue 21, 2025, Page(s) e1011594, ISSN 1553-7404
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pgen.1011594

Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy

Author(s): Lara Falcucci, Christopher M. Dooley, Douglas Adamoski, Thomas Juan, Justin Martinez, Angelina M. Georgieva, Kamel Mamchaoui, Cansu Cirzi, Didier Y. R. Stainier
Published in: Nature, 2025, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-08539-x

Control of cardiac contractions using Cre-lox and degron strategies in zebrafish

Author(s): Thomas Juan, Maëlle Bellec, Bárbara Cardoso, Héloïse Athéa, Nana Fukuda, Marga Albu, Stefan Günther, Mario Looso, Didier Y. R. Stainier
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2309842121

PDGFRA is a conserved HAND2 effector during early cardiac development

Author(s): Yanli Xu, Rupal Gehlot, Samuel J. Capon, Marga Albu, Jonas Gretz, Joshua Bloomekatz, Kenny Mattonet, Dubravka Vucicevic, Sweta Talyan, Khrievono Kikhi, Stefan Günther, Mario Looso, Beth A. Firulli, Miloslav Sanda, Anthony B. Firulli, Scott Allen Lacadie, Deborah Yelon, Didier Y. R. Stainier
Published in: Nature Cardiovascular Research, Issue 3, 2024, Page(s) 1531-1548, ISSN 2731-0590
Publisher: Nature Portfolio - Springer Nature
DOI: 10.1038/s44161-024-00574-1