Cellular basis of Artemisinin resistance in malaria parasites

Project Information

MALART

Grant agreement ID: 101021493

DOI

10.3030/101021493

EC signature date 26 August 2021

Start date 1 December 2021

End date 30 November 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 388 242,50

EU contribution

€ 2 388 242,50

Coordinated by

BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in Plasmodium falciparum parasites. mBio. 15(6):e0198123. doi: 10.1128/mbio.01981-23.

Author(s): Behrens HM, Schmidt S, Henshall IG, López-Barona P, Peigney D, Sabitzki R, May J, Maïga-Ascofaré O, Spielmann T
Published in: MBio, 2024, ISSN 2150-7511
Publisher: ASM Journals
DOI: 10.1128/mbio.01981-23

Identification of a Rabenosyn-5 like protein and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites

Author(s): Ricarda Sabitzki; Anna-Lena Rossmann; Marius Schmitt; Sven Flemming; Andres Guillen-Samander; Hannah Michaela Behrens; Ernst Jonscher; Katharina Hoehn; Ulrike Froehlke; Tobias Spielmann
Published in: Plos Biology, Issue 1, 2024, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1101/2023.04.05.535711

Identification of domains in<i>Plasmodium falciparum</i>proteins of unknown function using DALI search on Alphafold predictions

Author(s): Hannah Michaela Behrens; Tobias Spielmann
Published in: Scientifc Reports, Issue 1, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-60058-x

Critical interdependencies between Plasmodium nutrient flux and drugs

Author(s): Isabelle G. Henshall; Tobias Spielmann
Published in: Trends in Parasitology, Issue 2, 2023, ISSN 1471-4922
Publisher: Elsevier BV
DOI: 10.1016/j.pt.2023.08.008

The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites

Author(s): Sabine Schmidt; Jan Stephan Wichers-Misterek; Hannah Michaela Behrens; Jakob Birnbaum; Isabelle G. Henshall; Jana Dröge; Ernst Jonscher; Sven Flemming; Carolina Castro-Peña; Paolo Mesén-Ramírez; Tobias Spielmann
Published in: PLoS Pathogens, Vol 19, Iss 12, p e1011814 (2023), Issue 1, 2023, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1011814