Is there a link between diet and DNA damage?
There are many reports underscoring the association between nutrition and cancer risk, but the underlying mechanisms remain elusive. The EU-funded METAREPAIR project will work on the hypothesis that high-fat diets affect DNA repair processes, leading to genomic instability and epigenetic marks such as histone and RNA methylation. Researchers will conduct experiments on prostate cancer cells and determine how manipulation of key metabolites affects these epigenetic marks and DNA repair. Apart from fundamental knowledge, results will have translational impact and pave the way for precision nutrition interventions as an anticancer treatment.