Molecular inhibition of viral infectivity
Viruses must hijack cellular machinery to survive, replicate and spread. To maximise the information content of their genomes, viruses have adopted the mechanism of programmed ribosomal frameshifting, which allows parallel translation of multiple protein copies from the same mRNA molecule. The EU-funded RIBOSFL project focuses on the restriction factor Shiftless (SFL), which is known to block virus infectivity by inhibiting ribosomal frameshifting. Researchers aim to study the mechanism of action of SFL, which will pave the way for the design of new antiviral therapeutics. This is of great clinical significance for key pathogens such as HIV and SARS-CoV-2.
Fields of science
- medical and health scienceshealth sciencesinfectious diseasesRNA virusesHIV
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
- natural sciencesbiological sciencesmicrobiologyvirology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses