Multiphysics modelling and neural networks synergy to enhance the outcome of robotic catheter ablation for the treatment of atrial fibrillation

Información del proyecto

PhyNeTouch

Identificador del acuerdo de subvención: 101024463

DOI

10.3030/101024463

Proyecto finalizado el 31 Octubre 2023

Fecha de la firma de la CE 19 Marzo 2021

Fecha de inicio 1 Enero 2022

Fecha de finalización 31 Diciembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 212 933,76

Aportación de la UE

€ 212 933,76

Coordinado por

UNIVERSITY COLLEGE LONDON
United Kingdom

Periodic Reporting for period 1 - PhyNeTouch (Multiphysics modelling and neural networks synergy to enhance the outcome of robotic catheter ablation for the treatment of atrial fibrillation)

Período documentado: 2022-01-01 hasta 2023-12-31

Resumen del contexto y de los objetivos generales del proyecto

This Marie Sklodowska Curie Action (MSCA) is titled “Multiphysics modelling and neural networks synergy to enhance the outcome of robotic catheter ablation for the treatment of atrial fibrillation”. This project aims to propose novel computational methods to assist the improved delivery of cardiac radiofrequency ablation for the treatment of atrial fibrilation. This is an important topic for society because atrial fibrillation is the most common cardiac arrhythmia and a major risk factor for ischemic stroke with serious health and socioeconomic implications for EU. Despite the superior outcome of catheter ablation, its success rate remains limited, and the complication risk significant.

To address this challenge, the objectives of this project are:

(1) to predict bioheat distribution in tissue with high accuracy, and
(2) to achieve real-time feedback through Neural Networks.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Results of the project were the following:

(1) a meshless computational model was developed for lesion formation simulation during cardiac radiofrequency ablation
(2) simulations were evaluated with experimental data
(3) multisite ablation protocols were introduced in the simulation process
(4) physics informed neural networks were employed for lesion formation simulation

These results have been disseminated in three national and international conferences:
(1) BioMedEng’22, London 2022, United Kingdom
(2) The Hamlyn Symposium on Medical Robotics, London, United Kingdom
(3) IEEE Engineering in Medicine and Biology Society, Sydney, Australia

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

This project has progressed the state of the art by providing novel computational models employing emerging technologies such as meshless methods and physics informed neural networks. Such models have the potential to be integrated in clinical systems to assist the catheter ablation treatment of atrial fibrillation in the future. This would allow the delivery of improved healthcare with less implications having a positive socio-economic impact in the Eurozone and beyond.

Simulation of lesion formation during catheter ablation for different indentation force and angle