Periodic Reporting for period 1 - MONAGEL (anti-pseudoMOnas aeruginosa biofilm NAno-in-hydroGEL)
Période du rapport: 2022-01-01 au 2023-12-31
A new paradigm in research is that to fight biofilm infections, perturbating the biofilm might be a more effective strategy than using only classical antibiotics.Quorum sensing inhibition is such innovative strategy. Quorum sensing is the communication between bacteria regulating the biofilm. As the predictions of the WHO foresee the antibioresistance as one of the greatest danger of the 21st century, there is a dire need to create new strategies to fight bacterial infections.
To this end the concept of the MONAGEL is to formulate an inhalable lipid nanoparticles based hydrogel to create a differential release kinetic between hydrophilic antibiotics and lipophilic quorum sensing inhibitors to fight PA biofilms.