Project description
Insight in the role of axon myelination in the hippocampus
Storage and retrieval of memories occur in the hippocampus, the part of the brain that is responsible for learning and memory. Since these processes rely on the precise transmission of information, the EU-funded MyeSync project is interested in studying the role of axon myelination in memory consolidation and cognitive performance. Axon myelination involves the wrapping of neuronal axons with myelin which insulates them and ensures the fast transmission of electrical pulses. Researchers will undertake a multidisciplinary approach to investigate how biophysical changes in small neuronal compartments may alter neuronal networks and ultimately dictate behaviour.
Objective
The hippocampus located in the temporal lobe of the brain is of fundamental importance for storage and retrieval of episodic memories. Such brain computations take place at a time scale of milliseconds or less, and rely on neuronal information transfer over subcellular structures which are called axons. Neuronal precision and speed can be achieved by wrapping axons with multi-lamellar membrane sheets of myelin and is of critical importance for proper brain function. Until recently, myelination was thought to be exclusive to long-range excitatory neuronal projections. This view has been drastically revised, and it is now commonly accepted that myelination can be abundant around the axons of local inhibitory interneurons as well. Parvalbumin positive basket cells (PV+ BCs) are fast spiking interneurons which are prominent in the hippocampus where they contribute to the synchrony of action potentials of large populations of neurons. They function as clockworks that drive network oscillations such as sharp wave ripples, are critical for memory consolidation, and are highly abundant in hippocampal area CA2. Whether myelination of the CA2 PV+ BC axon plays a role in their temporally precise inhibitory function, and whether this supports temporally precise neuronal encoding and cognitive performance remains obscure. In this Marie Skłodowska-Curie fellowship, I will address this question by combining my expertise in subcellular patch-clamp methods with the expertise of the host on Ca2+ imaging, myelin physiology, and in vivo electrophysiology. The proposed multimethod and multidisciplinary study will be unique in showing how biophysical changes in small neuronal compartments will lead to alterations of neuronal networks and ultimately to behavioral alterations of the organism. The fellowship is expected to provide me with transferable skills and high throughput techniques that will greatly improve my chances to become an influential leader in the field of neuroscience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine physiology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1011 JV AMSTERDAM
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.