Periodic Reporting for period 1 - IMMUNE-GENEMEMO (Identification of transcriptional memory maintenance factors through a cell selection strategy)
Période du rapport: 2021-06-01 au 2023-05-31
Transcriptional memory is a biological process during which cells induced with a particular signal display increased rates of gene expression after re-stimulation at a later stage. In this project, I use an unbiased genetic strategy to identify novel transcriptional memory regulatory factors to understand the molecular mechanisms of the phenomenon. I next generalize the discovered knowledge to the biology of innate immune cells.
This project empowers me to establish myself as a scientific leader in the field. Insights from this research uncover new gene regulatory mechanisms and pave the way for manipulation of the innate immune system for the benefit of public health.
Overview of the exploitation and dissemination actions:
So far, in the project I published a paper in an international peer reviewed journal (EMBO journal) and presented the data as an invited speaker at the Harvard Medical School and the University of Gdansk.