Gaining insights into Enzymes Transition States: Superacid as new tool to design specific CAZymes inhibitors.

Project Information

GLYCOMIMIC

Grant agreement ID: 101026396

DOI

10.3030/101026396

Project closed

EC signature date 7 April 2021

Start date 1 September 2022

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 184 707,84

EU contribution

€ 184 707,84

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions

Author(s): Mathilde Armand, Alba Nin-Hill, Ana Ardá, Emanuela Berrino, Jérôme Désiré, Agnes̀ Martin-Mingot, Bastien Michelet, Jesuś Jiménez-Barbero, Yves Blériot, Carme Rovira, and Sébastien Thibaudeau
Published in: Journal of the American Chemical Society, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c11677

Accumulation, Characterization and Reactivity of Chiral Ammonium‐Carboxonium Dications in Superacid

Author(s): Emanuela Berrino, Thomas Cantin, Maxime Artault, Stefanie Beck, Christoph Jessen, Jérôme Marrot, Frédéric Guégan, Agnès Mingot, Andreas Kornath, Sébastien Thibaudeau
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202404066

Superacid-Synthesized Fluorinated Diamines Act as Selective hCA IV Inhibitors

Author(s): Emanuela Berrino, Bastien Michelet, Kassandra Vitse, Alessio Nocentini, Gianluca Bartolucci, Agnès Martin-Mingot, Paola Gratteri, Fabrizio Carta, Claudiu T. Supuran, Sébastien Thibaudeau
Published in: Journal of Medicinal Chemistry, 2024, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c01795