Immunological and Microbiota Priming of the Response to Infection

Project description

Role of gut microbiota in immune system development

The gut microbiota is a complex of intestinal microorganisms acquired in early life, which participate in the development of the immune system. Recent research revealed that a transient intestinal inflammatory state, the ‘weaning reaction’, occurs in mice in early life in response to rapid diversification of the gut microbiota. The microbiota and its metabolites in this weaning state induce a sub-type of intestine T regulatory cells, which regulate immune reactivity for the rest of one’s life. The EU-funded IMPRINT project will elucidate the role of the gut microbiota in the immune system in early life and its significance for susceptibility to infection and immunopathologies, such as allergies and colitis, later in life.

Fields of science

• natural sciences › biological sciences › microbiology › bacteriology
• medical and health sciences › health sciences › inflammatory diseases
• medical and health sciences › health sciences › infectious diseases
• medical and health sciences › basic medicine › immunology
• medical and health sciences › clinical medicine › allergology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

INSTITUT PASTEUR

Net EU contribution

€ 196 707,84

Address

Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Non-EU contribution

€ 0,00