In WP1, the researcher achieved the following milestones: (1) synthesizing synthetic intermediates, and (2) creating final photoswitchable compounds. Crafting these compounds posed a considerable challenge due to their unique combination of a lipophilic moiety and a polar head in a single molecule. The synthesis complexity was a primary challenge of this project, demanding an extended period to establish the correct procedures. The researcher also conducted comprehensive characterizations of photoswitchable compound isomerization, gaining valuable skills in organic chemistry. WP2 centered on microbiological aspects, diligently conducted by the researcher at the UK Health Security Agency and King's College London. Several months of the fellowship were dedicated to these microbiology experiments, expanding the researcher's skill set beyond their primary field. WP3 is ongoing with continued collaboration at King's College London. The researcher's secured UCL fellowship ensures active involvement in the project's progression and the completion of remaining experiments.
In addition, the researcher: (1) Gained extensive training in organic chemistry analytical techniques, including NMR, LCMS, and UV spectroscopy; (2) Facilitated a knowledge exchange, contributing strong medicinal chemistry and drug discovery expertise, while acquiring proficiency in organic synthesis, analytical chemistry, and microbiology through collaboration; (3) Actively managed the project by participating in scientific and non-scientific aspects, from executing experiments to scientific management; (4) Engaged in the financial management of the project, alongside the supervisor, ensuring efficient resource allocation; (5) Supervised master's students in drug discovery projects related to infectious diseases.
Overall, the project's results will be shared in a research paper co-authored primarily by the researcher, with valuable contributions from the supervisor and project collaborators.
