Project description
Flexible electronics could boost studies into brain neuron activity
Three-dimensional (3D) neural models such as spheroids and organoids are crucial for studying brain development and neurodegenerative disorders, and for assay development and screening in drug discovery. Research in in terms of their electrical activity is still in its infancy. Funded by the Marie Skłodowska-Curie Actions programme, the SPHELECTRO project aims to develop improved electrical recording techniques compared to state of the art. To this end, it plans to integrate a seamless array of flexible electronics with 3D nanostructured electrodes into 3D matrix-free brain models (spheroids and organoids) to achieve prolonged, routine electrophysiology recordings at cellular resolution.
Objective
Three-dimensional neural models such as spheroids and organoids hold the potential to recapitulate several aspects of the human brain at the level of gene expression, cell differentiation, network and formation, thus representing one of the most promising technology to study brain development as well as neurodegenerative disorders. Suitable for large-scale production and genetic engineering, 3D brain models represent a highly encouraging model for next-generation drug screening assays. However, the electrical functionality assessment of such 3D models and its relevance to the human brain is still at its infancy, with current techniques limited to acute electrophysiology recordings through invasive or superficial tools. In this project, through the combination of expertise from the researcher in flexible neuroelectronics and surface functionalization, and from the host in nanotechnology-based electrophysiology and iPSC organoids, the overall scientific objective of the SPHELECTRO project is to develop a Seamless Array of Flexible Electronics (SAFE) with 3D nanostructured electrodes, integrated into 3D matrix-free brain models (spheroids and organoids) during early stages of development for prolonged, routine electrophysiology recordings with cellular resolution. This original proof-of-concept would provide an exceptional tool for the neuroscience community to advance our understanding of brain development and neurological disorders, with high industrialization potential in the pharmacology field. The timeliness and high interdisciplinarity of this project, at the intersection of fast-growing research topics such as flexible electronics, nanotechnology and organoids, will greatly build up skill transfer between the host laboratory and the researcher, as well as to enable the latter to establish a unique research profile towards the perspective of becoming a group leader in the field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.