Development and implementation in clinical practice of the allogeneic use of thymus-derived regulatory T cells (thyTreg) as a cell therapy to suppress harmful immune responses

Project Information

Allo-THYTECH

Grant agreement ID: 101028834

DOI 10.3030/101028834

Project closed

EC signature date 24 March 2021

Start date 23 March 2022

End date 12 July 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 172 932,48

EU contribution € 172 932,48

Coordinated by

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON
Spain

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Publications

Peer reviewed articles (4)

A Novel GMP Protocol to Produce High-Quality Treg Cells From the Pediatric Thymic Tissue to Be Employed as Cellular Therapy

Author(s): Esther Bernaldo-de-Quirós, Beatriz Cózar, Rocío López-Esteban, Maribel Clemente, Juan Miguel Gil-Jaurena, Carlos Pardo, Ana Pita, Ramón Pérez-Caballero, Manuela Camino, Nuria Gil, María Eugenia Fernández-Santos, Susana Suarez, Marjorie Pion, Marta Martínez-Bonet, Rafael Correa-Rocha
Published in: Frontiers in Immunology, Issue 13, 2022, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.893576

A New Generation of Cell Therapies Employing Regulatory T Cells (Treg) to Induce Immune Tolerance in Pediatric Transplantation

Author(s): Esther Bernaldo-de-Quirós, Marjorie Pion, Marta Martínez-Bonet, Rafael Correa-Rocha
Published in: Frontiers in Pediatrics, Issue 10, 2023, ISSN 2296-2360
Publisher: Frontiers Media
DOI: 10.3389/fped.2022.862807

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant

Author(s): Esther Bernaldo-de-Quirós, Manuela Camino, Marta Martínez-Bonet, Juan Miguel Gil-Jaurena, Nuria Gil, Diana Hernández-Flórez, Maria Eugenia Fernández-Santos, Laura Butragueño, I. Esmé Dijke, Megan K. Levings, Lori J. West, Marjorie Pion, Rafael Correa-Rocha
Published in: Journal of Experimental Medicine, Issue 220, 2023, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20231045

Multidimensional analysis of immune cells from COVID-19 patients identified cell subsets associated with the severity at hospital admission

Author(s): Sergio Gil-Manso, Diego Herrero-Quevedo, Diego Carbonell, Marta Martínez-Bonet, Esther Bernaldo-de-Quirós, Rebeca Kennedy-Batalla, Jorge Gallego-Valle, Rocío López-Esteban, Elena Blázquez-López, Iria Miguens-Blanco, Rafael Correa-Rocha, Vanessa Gomez-Verdejo, Marjorie Pion
Published in: PLOS Pathogens, Issue 19, 2023, Page(s) e1011432, ISSN 1553-7374
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1011432