Cell division is controlled not only in time, but also in orientation. Our aim is to advance knowledge on how cell cycle regulates spindle positioning, crucial to orientate cell division. Specifically, this research aims to elucidate the role of CyclinB1 in the formation and orientation of the mitotic spindle and its contribution to epithelial morphogenesis through its interaction with NuMA. Therefore, our mains objectives are finding how, when, where and why CyclinB1 and NuMA interact.
I propose a multidisciplinary project to understand better the molecular mechanisms associated with cell division, spindle regulation, and its implication in epithelial morphogenesis. The cell cycle is intimately involved in all biological organisms' growth, development, reproduction, and aging; therefore, gaining insight into cell cycle controls will benefit the large community of biologists and medical sciences. Furthermore, establishing the correct orientation of the mitotic spindle is an essential step in epithelial cell division to ensure that epithelia tubes from correctly during organ development and regeneration. Disrupting of any of the spindle factors, could lead to aneuploidy, epithelial to mesenchymal transition and tissue disorganization. Moreover, a better understanding of mammalian cell cycle controls has significant potential to change medical treatments for cancer cells that have escaped the normal controls on growth and division in multicellular animals. Providing novel insights into cell cycle regulation and its implication in epithelial morphogenesis could potentially lead to therapies and treatments that could dramatically improve the economy's well-being, health, and creative output. Potential public sector health benefits would be realized over a more extended period.
