Tick-Virus Interactions Shape persistence and Transmission OF Flavivirus pathogen in tick vector

Project description

Role of tick–virus interaction in the transmission of tick-borne encephalitis

Tick-borne encephalitis virus (TBEV), transmitted by ticks, causes life-threatening encephalitis that involves the central nervous system. A better understanding of virus development inside ticks requires systematic studies, including novel models of virus–tick interactions. Funded by the Marie Skłodowska-Curie Actions programme, the TVISTOFF project aims to investigate the role of molecular factors in TBEV virulence and the impact of tick neurosecretory compounds on the adaptation and transmission of the virus. The interdisciplinary approach includes the development of innovative fluorescently labelled TBEV mutants, the implementation of a host-free tick feeding system using an artificial membrane, and the characterisation of tick neuroendocrine system components. The obtained results and novel tools will provide a research foundation for other diseases associated with tick-borne viruses.

Fields of science

• natural sciences › biological sciences › genetics
• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › basic medicine › physiology

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED, VEREJNA VYSKUMNA INSTITUCIA

Net EU contribution

€ 155 364,48

Address

Dubravska Cesta 9
845 05 Bratislava
Slovakia

Region

Slovensko › Bratislavský kraj › Bratislavský kraj

Activity type

Research Organisations

Links

Other funding

€ 0,00