Project description
Advanced biogenetic studies will help prevent and reverse aquatic pollution
The continuous release of organic contaminants (OCs) into the aquatic environment may have a significant impact on phytoplankton, which play a crucial role in aquatic ecosystems. Recent genomic studies have revealed multiple cytochrome P450 (CYP) genes in phytoplankton species, and toxicological studies have indicated their involvement in phytoplankton responses to OC exposure. The EU-funded PHYCOCYP project aims to improve our understanding of the processes behind the biotransformation of OCs into less toxic compounds. Researchers will investigate whether CYP genes expression is conserved in different phytoplankton classes exposed to OCs with different modes of action. The project's results will help evaluate the potential impact of OCs on phytoplankton and the implementation of biotransformation processes for OC removal and pollution remediation.
Objective
Anthropic activities result in a continuous release of Organic Contaminants (OCs) in the aquatic environment and chemical pollution may considerably affect phytoplankton that are photosynthetic microorganisms playing a major role in aquatic ecosystems. Adverse outcomes of OCs on phytoplankton are directly linked to the ability of the organism to face the toxic insult. OCs may be metabolized to less toxic compounds activating poorly understood biotransformation processes. The main objective of the PHYCOCYP project is to improve the mechanistic understanding of biotransformation processes and their role in phytoplankton tolerance to OCs. Among the numerous enzymes involved in xenobiotic biotransformation, a key role is played by Cytochrome P450 (CYPs). CYPs are found in all domains of life and were extensively studied in higher organisms. However, little information is available on the role of CYPs in OC biotransformation and tolerance in phytoplankton. The PHYCOCYP project will address this knowledge gap. Recent genomic studies highlighted the presence of multiple CYP genes in phytoplankton species and toxicological studies indicated their involvement in phytoplankton responses to OC exposure. In the proposed research, an initial screening will investigate whether CYP genes expression is conserved in different phytoplankton classes exposed to OCs with different modes of action. The involvement of CYPs in OC biotransformation and tolerance will be then assessed in a model phytoplankton specie integrating a genetic approach to physiological investigations and metabolic profiling of OC transformation products. Aquatic environment preservation and restoration is one of the main contemporary environmental challenges. Knowledge generated with PHYCOCYP project will help evaluate the potential impact of OC on key organisms of aquatic ecosystems and may serve for the implementation of biotransformation processes for OC removal and pollution remediation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences ecology ecosystems
- natural sciences biological sciences microbiology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.