Project description
Enlisting supramolecular hydrogels to fight coronavirus
Most vaccines in use today were developed using techniques invented more than 100 years ago. The design of vaccines that have ease of distribution and reduced cost remains a major technological challenge. In view of the COVID-19 pandemic, there is growing pressure to develop new technologies to address severe infectious diseases. The EU-funded HYPOVACC project will develop a novel biocompatible, injectable and scalable vaccine technology based on supramolecular hydrogel-containing polymersomes to enable controlled local vaccine exposure for durable and broadly protective immune response against the coronavirus. The project research will cover new vaccine delivery technologies and recently developed immunological assays.
Objective
In light of current events, developing new technologies for the fight against severe infectious diseases, such as the COVID-19 pandemic caused by the SARS-CoV-2 virus, is a global health emergency. Despite the tremendous improvement of vaccine technologies, the design of potent, durable and safe vaccines displaying an ease of distribution and a reduced cost, remains a major technological challenge. This research project proposes to develop a novel biocompatible, injectable and scalable vaccine technology based on supramolecular hydrogels-containing polymersomes to enable a controlled local vaccine exposure for durable and broadly protective immune response against the SARS-CoV-2 infection. The platform will leverage supramolecular hydrogels as depot carriers for a sustained co-release of complex mixtures of immunomodulatory compounds comprising a typical vaccine and polymersomes to enhance the presentation of subunit antigens. Immunogenicity will be improved through potent immune stimulating-adjuvants mixtures, selected from a precise screening of vastly different molecules in terms of chemical nature and size, and a controlled multipresentation of antigens by fine-tuned antigen-grafted polymersomes. This highly innovative project will cover various disciplines ranging from chemistry, material science, to bioengineering, and will use new polymersomes and hydrogels constructs, vaccine technology and recently developed immunological assays. The proposal will be conducted in two internationally recognized leading teams in the field of drug delivery systems in Bordeaux University, France and Stanford University, USA. The international exposure and the outstanding scientific environment gained through the fellowship will be a key step for the independence and maturity of the researcher. She will acquire a unique multidisciplinary research profile which will be of significant interest for her future independent career in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences public health epidemiology pandemics
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33000 BORDEAUX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.