PhotoChromic HYdrogen PERoxide biosensors for super-resolution imaging of hydrogen peroxide microenvironments

Project description

Advanced biosensors detect metabolically active microdomains within cells

In medicine, hydrogen peroxide is used as a disinfectant. However, at the cell level, it has a key role in cellular metabolism and tissue function. The EU-funded PCHYPERs project is interested in identifying the cellular microdomains where hydrogen peroxide is produced and initiates signalling. The current work is based on HYPER biosensors that change fluorescence when they detect oxygen peroxide and can be monitored through conventional microscopy. PCHYPERs researchers aim to advance this approach through photochromic variants and super-resolution microscopy that will help identify the locations of hydrogen peroxide signalling within cells at high resolution.

Fields of science

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › biosensors
• natural sciences › physical sciences › optics › microscopy › super resolution microscopy

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2020 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2020

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN

Net EU contribution

€ 178 320,00

Address

Oude Markt 13
3000 Leuven
Belgium

Region

Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00