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Hodgkin Lymphoma: Insights from genomic studies of mutations in coding and non-coding regions

Project description

Genomic studies of Hodgkin’s lymphoma biology

Hodgkin’s lymphoma (HL) is one of the most common cancers in young adults. Studying the mechanisms underlying the biology of HL abnormal B cells may aid in the development of better therapeutic strategies. Funded by the Marie Skłodowska-Curie Actions programme, the HodgkINsights project will study the function of mutations in the DNA binding domain of the STAT6 transcription factor, previously identified as a typical genetic lesion in HL. Application of genome-wide chromatin immunoprecipitation- and RNA-sequencing will uncover aberrant gene expression regulation and occupancy by mutant STAT6 in HL versus non-HL cell lines and help investigate functional consequences at the cellular level. Finally, genome-editing technologies will be used to assess how identified mutations may alter regulatory networks critical for HL biology.


Net EU contribution
€ 275 209,92
Piazza Dell Universita 1
06123 Perugia

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Centro (IT) Umbria Perugia
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00