Project description
Genomic studies of Hodgkin’s lymphoma biology
Hodgkin’s lymphoma (HL) is one of the most common cancers in young adults. Studying the mechanisms underlying the biology of HL abnormal B cells may aid in the development of better therapeutic strategies. Funded by the Marie Skłodowska-Curie Actions programme, the HodgkINsights project will study the function of mutations in the DNA binding domain of the STAT6 transcription factor, previously identified as a typical genetic lesion in HL. Application of genome-wide chromatin immunoprecipitation- and RNA-sequencing will uncover aberrant gene expression regulation and occupancy by mutant STAT6 in HL versus non-HL cell lines and help investigate functional consequences at the cellular level. Finally, genome-editing technologies will be used to assess how identified mutations may alter regulatory networks critical for HL biology.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
Coordinator
06123 Perugia
Italy
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