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European platform for neurodegenerative disorders

Objective

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are common neurodegenerative conditions, posing a major societal burden. There is a lack of treatments to slow disease progression, and therapeutic development has been impeded by a lack of biomarkers that can detect individuals early in the disease, measure treatment effects, and stratify patients.

European cohorts recruited for research on aging and neurodegeneration provide a huge potential for biomarker discovery and validation by providing bio-samples along with deep clinical and imaging phenotypes. However, these cohorts are difficult to access. An overview of the availability of data and samples is lacking, and protocols and regulations for data and sample collection, storage, and sharing vary.

The European Platform for Neurodegenerative Diseases (EPND) will tackle the above issues by developing a self-sustaining European-based platform to facilitate discovery and access of relevant bio-samples and data. EPND will be built on an existing informatics infrastructure, the AD Workbench, which EPND will adapt to support resource- and participant-level discovery, data harmonisation, central and federated data and sample storage, and data analysis. The sample and data discovery tools will be connected to a network of over 60 cohorts on AD, PD, and related disorders. Together, these cohorts will facilitate access to data and samples of over 120,000 research participants including CSF (n=30,000), plasma (n=120,000), stools (n=6,000), urine (n=27,000), saliva (n=17,000) and digital biomarkers (n=2,000). Prospective data collection will also occur during the project. This approach provides the community with a new and powerful environment for collaborative cross study analysis of harmonised biomarkers, datasets and samples. EPND will provide visibility into the quality and standardization of the data and samples available in the platform from the cohorts available and will also provide protocols for ongoing data and sample collection. This will guarantee quality of samples available, an important factor for validation and regulatory approval for biomarkers.

EPND will be guided by ethical, legal and regulatory experts, patients, and other stakeholders to ensure responsible practices and processes underpin all discovery, sharing and access of data and samples, whilst simultaneously ensuring the platform is self-sustainable by the end of the project. Thereby, EPND will provide the community with a long-term, powerful environment to aid biomarker research for neurodegenerative disorders, enabling critical advances in the development of treatments for AD and PD.

Call for proposal

H2020-JTI-IMI2-2020-23-two-stage
See other projects for this call

Coordinator

UNIVERSITEIT MAASTRICHT
Address
Minderbroedersberg 4
6200 MD Maastricht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 046 501

Participants (28)

UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 778 710
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
EU contribution
€ 216 195
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
EU contribution
€ 375 225
Address
Venusberg-campus 1/99
53127 Bonn
Activity type
Research Organisations
STICHTING VUMC
Netherlands
EU contribution
€ 881 625
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
UNIVERSITE DU LUXEMBOURG
Luxembourg
EU contribution
€ 1 493 233
Address
2 Avenue De L'universite
4365 Esch-sur-alzette
Activity type
Higher or Secondary Education Establishments
BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)
Austria
EU contribution
€ 313 875
Address
Neue Stiftingtalstrasse 2/B/6
8010 Graz
Activity type
Research Organisations
STICHTING LYGATURE
Netherlands
EU contribution
€ 596 125
Address
Jaarbeursplein 6
3521 AL Utrecht
Activity type
Other
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 621 500
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
ALZHEIMER EUROPE
Luxembourg
EU contribution
€ 354 152
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other
BMD SOFTWARE LDA
Portugal
EU contribution
€ 261 568
Address
Rua Calouste Gulbenkian 1 Edificio A
3810 074 Aveiro
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EATRIS ERIC
Netherlands
EU contribution
€ 515 250
Address
De Boelelaan 1118
1081 HZ Amsterdam
Activity type
Research Organisations
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 192 416
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 315 250
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 155 875
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
ARIDHIA INFORMATICS LIMITED
United Kingdom
EU contribution
€ 141 000
Address
163 Bath Street
G2 4SQ Glasgow
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 166 250
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
EU contribution
€ 71 500
Address
Val Fleuri 84
1526 Luxembourg
Activity type
Research Organisations
AGENTSCHAP COLLEGE TER BEOORDELING VAN GENEESMIDDELEN
Netherlands
EU contribution
€ 183 750
Address
Graadt Van Roggenweg 500
3531AH Utrecht
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 0
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAKEDA PHARMACEUTICALS INTERNATIONAL AG
Switzerland
EU contribution
€ 0
Address
Thurgauerstrasse 130
8152 Glattpark
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB BIOPHARMA
Belgium
EU contribution
€ 0
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GATES VENTURES LLC
United States
EU contribution
€ 0
Address
4110 Carilon Point
98033 Kirkland
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SVAR LIFE SCIENCE AB
Sweden
EU contribution
€ 0
Address
.
202 11 Malmo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AC IMMUNE SA
Switzerland
EU contribution
€ 0
Address
Parc Scientifique Epfl Pse B
1015 Lausanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TEVA PHARMACEUTICAL INDUSTRIES LIMITED
Israel
EU contribution
€ 0
Address
5 Basel St
49131 Petach Tivka
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)