WP1: Project Management – WP1 actively monitors the progress and identifies and mitigates any potential risks for the project. WP1 also delivered the periodic reports and organises annual face-to-face consortium meetings.
WP2: Informed consent, general requirement analysis, governance, and regulation – The WP has assessed the legal and ethical framework of the project, as well as the data protection impact, which serve as important prerequisites for any further work within the OPTIMA project. The Art. 26/28 agreements have been drafted and signed by all beneficiaries. WP2 has supported in drafting the regulatory plan for OPTIMA and is now finalising the external data sharing agreements.
WP3: Guideline-based decision support tool – The WP has identified and prioritised critical research questions through Delphi surveys with key opinion leaders and stakeholders, and selected typical case presentations for prostate, breast and lung cancer, which will serve as the basis for the development of the guideline-based decision support tool. Currently, WP3 is further developing the GBDST to include lung and breast cancer and preparing for an in silico trial to assess guideline adherence.
WP4: Platform technical and infrastructural requirement analysis – The WP has created an initial data management plan, provided an updated version of the data management plan, assessed the requirements and specifications of the platform, and worked on the development environment. Several versions of the platform have been developed and released in collaboration with the other technical WPs.
WP5: Platform implementation and evaluation – The WP has identified the user personas and have implemented several successive versions of the platform in the technical testing sites and clinical sites. WP5 is evaluating the platform on an ongoing basis. The WP will continuously search for additional sites where new versions can be tested.
WP6: (Non)interventional study data and real-world data gathering, preparation and integration – The WP has been mapping potential datasets, designed the architecture of federated nodes and decided on the common data model approach used. This WP has developed a fingerprinting questionnaire to assess the data governance, helped in the design of the architecture of the federated notes, assessed the security of data AI-models, organized trainings on semi-automated tools for OMOP-mapping, and decided on a strategy to convert datasets from the consortium partners into OMOP. Recently, WP6 developed the OPTIMA data catalogue.
WP7: Artificial intelligence knowledge base implementation – The WP has investigated the use of synthetic data, assessed available AI/ML models, explored options for federated learning and started the work around NLP. WP7 has developed an overview of the state of the art for AI models in the three cancer types investigated in OPTIMA and has started the development of a prototype AI model relevant to answer research questions that can benefit from automatic analysis of imaging data. WP7 has also provided input to assess the impact of AI both for answering the research questions as well as business cases for the sustainability of OPTIMA. In terms of infrastructure, collection of AI models and a working CI/CD environment are now set up. WP7 has developed several AI models, which are in the process of being quality assessed.
WP8: Dissemination and communication – focuses on dissemination and communication of the project’s aims, approach and results, strengthening stakeholder engagement. The WP has established the house-style, developed templates and manages OPTIMA social media accounts. WP8 have created a network with relevant stakeholders and are creating new communication materials on an ongoing basis.
WP9: Exploitation and sustainability of the results – aims to build a sound and solid business strategy to exploit and commercialize the platform and the guideline decision support tool beyond the grant period. The WP has conducted interviews to assess scientific requirements, benchmarked potential business models and defined models for commercialization. WP9 has collaborated with the other WPs and conducted workshops and held meetings to further define a sustainable model for OPTIMA.
