A new ERA for Environmental Risk Assessment: Chirality as a tool towards environmentally safe pharmaceuticals

Informations projet

ERA-ARE

N° de convention de subvention: 101039270

DOI

10.3030/101039270

Date de signature de la CE 10 Octobre 2022

Date de début 1 Mars 2023

Date de fin 29 Février 2028

Financé au titre de

• European Research Council (ERC)

Coût total

€ 1 499 950,00

Contribution de l’UE

€ 1 499 950,00

Coordonné par

UNIVERSIDADE DO PORTO
Portugal

Periodic Reporting for period 1 - ERA-ARE (A new ERA for Environmental Risk Assessment: Chirality as a tool towards environmentally safe pharmaceuticals)

Période du rapport: 2023-03-01 au 2025-08-31

Résumé du contexte et des objectifs généraux du projet

Pharmaceuticals, their metabolites and transformation products (TPs), are stable, poorly biodegraded and recalcitrant, and thus responsible for the emerging contamination of aquatic environments by them. Existing novel mitigation measures are insufficient and often too risky due to the possible generation of TPs. As such, a disruptive prevention strategy is urgently needed. The ERC-funded ERA-ARE project will build a robust base for the realisation of an internationally leading research group promoting environmental safety. The ERA|ARE innovative method relies on fundamental understanding of enantioselectivity of environmental processes that can impact the fate/behaviour of pharmaceutical contaminants. The project will exploit the chirality of selected antibiotics as a piloting tool, to reduce antibiotic resistance and create innovative guidelines for developing safer drugs.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Liquid Chromatography coupled to tandem Mass Spectrometry (LC-MS/MS) methods for determination of several classes of pharmaceuticals, pesticides and illicit drugs;

Sample preparation procedures to extract these compounds from environmental matrices;

Semi-preparative chiral chromatography method to isolate pure enantiomers for further biodegradation/ ecotoxicological assays;

A spatiotemporal monitoring campaign was developed in the Douro River from Pinhão to the mouth of the river;

Enrichment of fluoroquinolone-degrading bacteria.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

(i) Development of new analytical and semi-preparative methods to support biodegradation/ ecotoxicological assays;
(ii) New research infrastructure at U.Porto;
(iii) Training and knowledge dissemination;
(iv) International collaborative networks.