Objective
The evolutionary processes underlying interactions between hosts and their associated microbes is a black box on which biologists have long attempted to shed light. A limiting factor has been knowledge of the precise molecular events, which are now increasingly possible to elucidate with the advent of next-generation sequencing technologies. The Big Data era have revolutionized evolutionary studies through sequencing of thousands of genomes allowing tracing genomic changes. Coupled to these technologies experimental evolution transformed evolution from a predictive to a functional science by opening a window on evolutionary changes in real-time. The challenge that now awaits evolutionary science is in identifying the trajectories simultaneously driving evolution in hosts and microbes. In this context, HoloE2Plant will validate the holobiont concept by looking at the simultaneous evolution of the host and its microbiome. This will be possible thanks to an experimental coevolution approach applied to fast-cycling Brassica rapa plants and Synthetic Microbial Communities (SynComs). SynComs will be selected from bacterial and fungal collections previously established from wild B. rapa populations. This ambitious project is timely and feasible thanks to the combination of high-throughput sequencing, cutting-edge modelling methods for microbial functional network reconstruction and a novel co-evolutionary quantitative genetic approach that will be developed here. Experimental evolution will be carried out in presence/absence of the fungal pathogen Rhizoctonia solani and the genetic bases underlying microbial-plant interactions and associated with disease resistance will be identified. HoloE2Plant will contribute to validating the holobiont concept and will provide unique methods to identify rapid evolutionary changes in holobionts; these theoretical advances will set the stage for future applied projects aiming at designing microbial consortia with biocontrol properties.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences microbiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75007 PARIS CEDEX 07
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.