Deciphering and Exploiting the chemical features of Silent Lipopolysaccharides: a gift from gut microbiota

Project Information

DEBUGGING-LPS

Grant agreement ID: 101039841

DOI

10.3030/101039841

EC signature date 8 March 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 954 308,00

EU contribution

€ 1 954 308,00

Coordinated by

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

The human gut Bacteroides eggerthii expresses a new galactofuranose-containing lipooligosaccharide with weak immunostimulatory properties

Author(s): Marta Tiemblo Martín, Magali Coccimiglio, Emanuela Andretta, Luca De Simone Carone, Andrew Bell, Tania Gerpe-Amor, Cristina Di Carluccio, Antonio Molinaro, Yvette van Kooyk, Nathalie Juge, Fabrizio Chiodo, Flaviana Di Lorenzo, Alba Silipo
Published in: Carbohydrate Polymers, Issue 348, 2025, ISSN 0144-8617
Publisher: Elsevier BV
DOI: 10.1016/j.carbpol.2024.122833

Angewandte Chemie - International Edition

Author(s): Pither, Molly Dorothy; Andretta, Emanuela; Rocca, Giuseppe; Balzarini, Fabio; Matamoros‐Recio, Alejandra; Colicchio, Roberta; Salvatore, Paola; van Kooyk, Yvette; Silipo, Alba; Granucci, Francesca; Martin‐Santamaria, Sonsoles; Chiodo, Fabrizio; Molinaro, Antonio; Di Lorenzo, Flaviana
Published in: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202401541

Bucking the trend: understanding lipopolysaccharide structure and outer membrane dynamics in cold-adapted <i>Pseudomonas</i> isolated from Enigma Lake, Antarctica

Author(s): Marcello Mercogliano, Stefania De Chiara, Antonio De Nicola, Jacopo Cardellini, Costanza Montis, Mikhail M. Yakimov, Violetta La Cono, Francesca Crisafi, Alba Silipo, Debora Berti, Giuseppe Milano, Antonio Molinaro, Flaviana Di Lorenzo
Published in: Chemical Science, 2024, ISSN 2041-6520
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4sc05116e

Exopolysaccharide is detrimental for the symbiotic performance of <i>Sinorhizobium fredii</i> HH103 mutants with a truncated lipopolysaccharide core

Author(s): Francisco Fuentes-Romero, Marcello Mercogliano, Stefania De Chiara, Cynthia Alias-Villegas, Pilar Navarro-Gómez, Sebastián Acosta-Jurado, Alba Silipo, Carlos Medina, Miguel-Ángel Rodríguez-Carvajal, Marta S. Dardanelli, José-Enrique Ruiz-Sainz, Francisco-Javier López-Baena, Antonio Molinaro, José-María Vinardell, Flaviana Di Lorenzo
Published in: Biochemical Journal, Issue 481, 2024, ISSN 0264-6021
Publisher: Portland Press Ltd.
DOI: 10.1042/BCJ20240599

Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica

Author(s): Emanuela Andretta, Stefania De Chiara, Chiara Pagliuca, Roberta Cirella, Elena Scaglione, Martina Di Rosario, Maxim S. Kokoulin, Olga I. Nedashkovskaya, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo
Published in: Glycoconjugate Journal, Issue 41, 2024, ISSN 0282-0080
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s10719-024-10149-8

The chemistry of gut microbiome-derived lipopolysaccharides impacts on the occurrence of food allergy in the pediatric age

Author(s): Flaviana Di Lorenzo, Lorella Paparo, Laura Pisapia, Franca Oglio, Molly Dorothy Pither, Roberta Cirella, Rita Nocerino, Laura Carucci, Alba Silipo, Francesca de Filippis, Danilo Ercolini, Antonio Molinaro, Roberto Berni Canani
Published in: Frontiers in Molecular Biosciences, Issue 10, 2023, ISSN 2296-889X
Publisher: Frontiers Media SA
DOI: 10.3389/fmolb.2023.1266293

Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide

Author(s): Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana E. Adade, Dervla T. D. Kenna, Beverley C. Millar, John E. Moore, José Ramos Vivas, Antonio Molinaro, Miguel A. Valvano
Published in: Microbiology Spectrum, Issue 11, 2023, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.03729-22

Lipopolysaccharides from Ralstonia solanacearum induce a broad metabolomic response in Solanum lycopersicum

Author(s): Dylan R. Zeiss, Antonio Molinaro, Paul A. Steenkamp, Alba Silipo, Lizelle A. Piater, Flaviana Di Lorenzo, Ian A. Dubery
Published in: Frontiers in Molecular Biosciences, Issue 10, 2023, ISSN 2296-889X
Publisher: Frontiers Media SA
DOI: 10.3389/fmolb.2023.1232233

The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity

Author(s): Pilar Garcia-Vello, Hanne L. P. Tytgat, Janneke Elzinga, Matthias Van Hul, Hubert Plovier, Marta Tiemblo-Martin, Patrice D. Cani, Simone Nicolardi, Marco Fragai, Cristina De Castro, Flaviana Di Lorenzo, Alba Silipo, Antonio Molinaro, Willem M. de Vos
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41467-024-52683-x

Bacterial lipids drive compartmentalization on the nanoscale

Author(s): Antonio De Nicola, Costanza Montis, Greta Donati, Antonio Molinaro, Alba Silipo, Arianna Balestri, Debora Berti, Flaviana Di Lorenzo, You-Liang Zhu, Giuseppe Milano
Published in: Nanoscale, Issue 15, 2024, ISSN 2040-3364
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3NR00559C

Atomic-Level Dissection of DC-SIGN Recognition of <i>Bacteroides vulgatus</i> LPS Epitopes

Author(s): Ferran Nieto-Fabregat, Qian Zhu, Corinne Vivès, Yunqin Zhang, Angela Marseglia, Fabrizio Chiodo, Michel Thépaut, Diksha Rai, Suvarn S. Kulkarni, Flaviana Di Lorenzo, Antonio Molinaro, Roberta Marchetti, Franck Fieschi, Guozhi Xiao, Biao Yu, Alba Silipo
Published in: JACS Au, Issue 4, 2024, ISSN 2691-3704
Publisher: American Chemical Society (ACS)
DOI: 10.1021/jacsau.3c00748

Pushing the Boundaries of Structural Heterogeneity with the Lipid A of Marine Bacteria <i>Cellulophaga</i>

Author(s): Roberta Cirella, Chiara Pagliuca, Molly Dorothy Pither, Elena Scaglione, Olga I. Nedashkovskaya, Oleg V. Chernikov, Kuo‐Feng Hua, Roberta Colicchio, Mariateresa Vitiello, Maxim S. Kokoulin, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo
Published in: ChemBioChem, Issue 24, 2023, ISSN 1439-4227
Publisher: Wiley
DOI: 10.1002/cbic.202300183

Expanding Knowledge of Methylotrophic Capacity: Structure and Properties of the Rough-Type Lipopolysaccharide from <i>Methylobacterium extorquens</i> and Its Role on Membrane Resistance to Methanol

Author(s): Flaviana Di Lorenzo, Simone Nicolardi, Roberta Marchetti, Adele Vanacore, Noemi Gallucci, Katarzyna Duda, Ferran Nieto Fabregat, Ha Ngoc Anh Nguyen, Djamel Gully, James Saenz, Eric Giraud, Luigi Paduano, Antonio Molinaro, Gerardino D’Errico, Alba Silipo
Published in: JACS Au, Issue 3, 2023, ISSN 2691-3704
Publisher: American Chemical Society (ACS)
DOI: 10.1021/jacsau.3c00025

Book chapters (1)

Methods in molecular biology (Clifton, N.J.)

Author(s): Molly Dorothy Pither, Alba Silipo, Antonio Molinaro, Flaviana Di Lorenzo
Published in: Methods in Molecular Biology, Glycolipids, 2023, ISSN 1064-3745
Publisher: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2910-9_13