Chemical rewiring of E3 ubiquitin ligases as a generalizable therapeutic approach

Project Information

TrickE3

Grant agreement ID: 101040046

DOI

10.3030/101040046

EC signature date 14 February 2022

Start date 1 March 2022

End date 28 February 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 625,00

EU contribution

€ 1 499 625,00

Coordinated by

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders

Author(s): Bárbara M. G. Barbosa, Aikaterini Sfyaki, Sergi Rafael, Ferran José-Duran, Joan Pous, Carolina Sánchez-Zarzalejo, Carles Perez-Lopez, Mar Vilanova, Marko Cigler, Marina Gay, Marta Vilaseca, Georg E. Winter, Antoni Riera, Cristina Mayor-Ruiz
Published in: Angewandte Chemie International Edition, 2023, ISSN 1521-3773
Publisher: Willey
DOI: 10.1002/anie.202316730

Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation

Author(s): Jake A. Ward, Carles Perez-Lopez, Cristina Mayor-Ruiz
Published in: Chembiochem, 2023, ISSN 1439-7633
Publisher: Wiley
DOI: 10.1002/cbic.202300163

Chasing molecular glue degraders: screening approaches

Author(s): Ana Domostegui, Luis Nieto Barrado, Carles Perez Lopez, Cristina Mayor-Ruiz
Published in: Chemical Society Reviews, 2022, ISSN 1460-4744
Publisher: RSC Publishing
DOI: 10.1039/D2CS00197G

Chemical rewiring of ubiquitination by degraders and their selectivity routes

Author(s): Rory Whelan, Cristina Mayor-Ruiz
Published in: Nature Structural & Molecular Biology, Issue 31, 2024, ISSN 3836-6231
Publisher: Nature Portfolio
DOI: 10.1038/s41594-024-01215-8

Book chapters (1)

Molecular glue degraders: From serendipity to hunting and design

Author(s): Luis Nieto-Barrado, Ana Domostegui, Cristina Mayor-Ruiz
Published in: Wiley VCH, 2022, ISBN 9783527836208
Publisher: Wiley VCH
DOI: 10.1002/9783527836208.ch6