Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
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Author(s):
Bárbara M. G. Barbosa, Aikaterini Sfyaki, Sergi Rafael, Ferran José-Duran, Joan Pous, Carolina Sánchez-Zarzalejo, Carles Perez-Lopez, Mar Vilanova, Marko Cigler, Marina Gay, Marta Vilaseca, Georg E. Winter, Antoni Riera, Cristina Mayor-Ruiz
Published in:
Angewandte Chemie International Edition, 2023, ISSN 1521-3773
Publisher:
Willey
DOI:
10.1002/anie.202316730
Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation
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Author(s):
Jake A. Ward, Carles Perez-Lopez, Cristina Mayor-Ruiz
Published in:
Chembiochem, 2023, ISSN 1439-7633
Publisher:
Wiley
DOI:
10.1002/cbic.202300163
Chasing molecular glue degraders: screening approaches
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Author(s):
Ana Domostegui, Luis Nieto Barrado, Carles Perez Lopez, Cristina Mayor-Ruiz
Published in:
Chemical Society Reviews, 2022, ISSN 1460-4744
Publisher:
RSC Publishing
DOI:
10.1039/D2CS00197G
Chemical rewiring of ubiquitination by degraders and their selectivity routes
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Author(s):
Rory Whelan, Cristina Mayor-Ruiz
Published in:
Nature Structural & Molecular Biology, Issue 31, 2024, ISSN 3836-6231
Publisher:
Nature Portfolio
DOI:
10.1038/s41594-024-01215-8
