Within days of Covid-19 reaching Europe in early 2020, music had emerged as one of the most prominent media for emotional engagement with the effects of lockdown, sickness and grief. Starting in Italy, musicians played from their balconies in shared solidarity; on YouTube, videos of digital choirs and orchestras “went viral” and moved thousands of viewers; and by the end of the year, Tiktok – built around shared sounds – had become the most popular new app on social media, connecting users who would otherwise have felt isolated. Although music culture, education and economics had been heavily disrupted by closures and social distancing measure, the primacy of music for expressing, navigating and shaping emotional experiences of the pandemic was remarkable. Journalists showed an immediate interest in finding evidence both for the role of music in past pandemics and for continuities with today, while researchers gathered by Zoom to discuss the impact of music on emotional well-being during major health crises such as Covid-19. It quickly transpired, however, that both lacked an established research vocabulary, shared methodologies and sufficient historical knowledge to describe, evaluate or analyse the phenomenon adequately. The study of music in times of pandemics, and especially of its emotional significance, is both underdeveloped and urgently needed – and has the potential to constitute a major new field in research on music, emotions and pandemics. GOING VIRAL is the first major study to provide a comparative history of the imbrication of music in the emotional experiences of pandemics. Its legacy will be both ground-breaking historical knowledge about the role of music during major historical pandemics since the 17th century and the development of an analytic terminology and a comparative methodology for the study of music and emotions, both famously challenging subjects of study, across time and space, in pandemics and beyond.