Project description DEENESFRITPL A binary platform for biomarker detection Early diagnosis of many diseases improves clinical outcomes as it offers the opportunity to provide care at the earliest possible stage. To be able to implement such a public health strategy in all settings, there is a need for disease-specific biomarkers that can be monitored non-invasively. The mission of the EU-funded NoOne project is to develop a bioelectronic sensor that can measure both genomic and protein-based biomarkers in various biological samples. The NoOne platform will offer results in a binary form, recording samples with at least one positive biomarker, and assist the detection of diseases such as cancer and bacterial infections in a reliable, fast and cost-effective way. Show the project objective Hide the project objective Objective Biomarkers are measurable indicators of a particular disease state of an organism. There has been an increasing demand for diagnostic markers, enabling reliable and non-invasive screening of peripheral biofluids. It is also established that a universal screening against life-threatening diseases, such as cancer, or infectious disease outbreaks, can be accomplished only by combining genomic and protein marker-based tests. The NoOne project aims at conceiving, engineering, fabricating and validating a ground-breaking platform based on a single-molecule binary bioelectronic sensor, capable to reliably discriminate biofluid samples enclosing zero biomarkers from those containing just one. The technology can be used for ultimate binary sensing of both proteins/peptides and genomic markers to enable the reliable screening of diseases such as cancer as well as viral and bacterial infections. The NoOne binary platform is designed to be portable, cost-effective, easy to operate and with a time-to-results within one hour; hence it is the ideal candidate for point-of-care applications. The prototype will enable clinicians, phytopathologists or veterinaries, to identify the set of samples that are totally free from a protein, peptide or genomic marker as well as from a pathogen (virus or bacteria), from those enclosing at least one with a confidence level of 99%. This makes the NoOne platform the best performing ever in enabling a fast, highly reliable, cost-effective identification of the subset of biological samples belonging to the potentially diseased part of a population. This is of paramount importance for predictive screening of humans, plants or animals. NoOne will demonstrate its effectiveness in key relevant applications such as the binary detection of pancreatic cancer biomarkers, SARS-CoV-2 virus, the Xylella Fastidiosa bacterium and the assay of post translational peptides evidencing the phosphorylated forms regulating crosstalk with oncogenic signalling pathways. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesmedical and health sciencesclinical medicineoncologypancreatic cancer Keywords biosensors organic bioelectronics analytical chemistry biological markers screening organic filed-effect transistors Programme(s) HORIZON.1.1 - European Research Council (ERC) Main Programme Topic(s) ERC-2021-STG - ERC STARTING GRANTS Call for proposal ERC-2021-STG See other projects for this call Funding Scheme HORIZON-ERC - HORIZON ERC Grants Coordinator UNIVERSITA DEGLI STUDI DI BARI ALDO MORO Net EU contribution € 1 969 012,75 Address Piazza umberto i 1 70121 Bari Italy See on map Region Sud Puglia Bari Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ABO AKADEMI Finland Net EU contribution € 530 566,25 Address Domkyrkotorget 3 20500 Abo See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
