Chemical biology of intracellular cholesterol transport

Project Information

ChemBioChol

Grant agreement ID: 101041783

DOI

10.3030/101041783

EC signature date 28 April 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 786,00

EU contribution

€ 1 499 786,00

Coordinated by

DANMARKS TEKNISKE UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Fluorescent probes and degraders of the sterol transport protein Aster-A

Author(s): Nianzhe He, Laura Depta, Sonja Sievers, Luca Laraia
Published in: Bioorganic & Medicinal Chemistry, Issue 103, 2024, ISSN 0968-0896
Publisher: Elsevier BV
DOI: 10.1016/j.bmc.2024.117673

Unifying principles for the design and evaluation of natural product-inspired compound collections

Author(s): Frederik Simonsen Bro; Luca Laraia
Published in: Chemical Science, 2025, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/D4SC08017C

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

Author(s): Laura Depta, Hogan P. Bryce-Rogers, Nienke J. Dekker, Anna Wiehl Bønke, Nicolò Camporese, Mingxing Qian, Yuanjian Xu, Douglas F. Covey, Luca Laraia
Published in: Journal of Lipid Research, Issue 66, 2025, ISSN 0022-2275
Publisher: Elsevier BV
DOI: 10.1016/J.JLR.2024.100738

Identification of a privileged scaffold for inhibition of sterol transport proteins through the synthesis and ring distortion of diverse, pseudo-natural products

Author(s): Frederik Simonsen Bro; Laura Depta; Nienke Dekker; Hogan Bryce-Rogers; Kaia Præstegaard; Tino Petersson; Thomas Whitmarsh-Everiss; Mariusz Kubus; Luca Laraia
Published in: ChemRXiv, 2024, ISSN 2573-2293
Publisher: CUP
DOI: 10.26434/chemrxiv-2024-mrdg3

Identification of a Privileged Scaffold for Inhibition of Sterol Transport Proteins through the Synthesis and Ring Distortion of Diverse, Pseudo-Natural Products

Author(s): Frederik Simonsen Bro; Laura Depta; Nienke J. Dekker; Hogan P. Bryce-Rogers; Maria Lillevang Madsen; Kaia Fiil Præstegaard; Tino Petersson; Thomas Whitmarsh-Everiss; Mariusz Kubus; Luca Laraia
Published in: ACS Central Science, 2025, ISSN 2374-7951
Publisher: American Chemical Society
DOI: 10.1021/ACSCENTSCI.4C01657