Subtype as a key to reduce heterogeneity of treatment effects in major depressive disorder

Informations projet

SUBTREAT

N° de convention de subvention: 101042183

DOI

10.3030/101042183

Date de signature de la CE 2 Mars 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2027

Financé au titre de

• European Research Council (ERC)

Coût total

€ 1 500 000,00

Contribution de l’UE

€ 1 500 000,00

Coordonné par

KAROLINSKA INSTITUTET
Sweden

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Publications

Peer reviewed articles (10)

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression

Auteurs: Guintivano, Jerry; Byrne, Enda M.; Kiewa, Jacqueline; Yao, Shuyang; Bauer, Anna E.; Aberg, Karolina A.; Adams, Mark J.; Campbell, Archie; Campbell, Megan L.; Choi, Karmel W.; Corfield, Elizabeth C.; Havdahl, Alexandra; Hucks, Donald; Koen, Nastassja; Lu, Yi; Mægbæk, Merete L.; Mullaert, Jimmy; Peterson, Roseann E.; Raffield, Laura M.; Sallis, Hannah M.; Sealock, Julia M.; Walker, Alicia; Watson, Hunna J.; Xiong, Ying; Yang, Jessica M.K.; Anney, Richard J.L.; Gordon-Smith, Katherine; Hubbard, Leon; Jones, Lisa A.; Mihaescu, Raluca; Nyegaard, Mette; Pardiñas, Antonio F.; Perry, Amy; Saquib, Nazmus; Shadyab, Aladdin H.; Viktorin, Alexander; Andreassen, Ole A.; Bigdeli, Tim B.; Davis, Lea K.; Dennis, Cindy-Lee; Di Florio, Arianna; Dubertret, Caroline; Feng, Yen-Chen A.; Frey, Benicio N.; Grigoriadis, Sophie; Gloaguen, Emilie; Jones, Ian; Kennedy, James L.; Krohn, Holly; Kunovac Kallak, Theodora; Li, Yun; Martin, Nicholas G.; McIntosh, Andrew M.; Milgrom, Jeannette; Munk-Olsen, Trine; Oberlander, Tim; Olsen, Catherine M.; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Robertson Blackmore, Emma; Rubinow, David; Skalkidou, Alkistis; Smoller, Jordan W.; Stein, Dan J.; Stowe, Zachary N.; Taylor, Valerie; Tebeka, Sarah; Tesli, Martin; Van Lieshout, Ryan J.; van den Oord, Edwin J.C.G.; Vigod, Simone N.; Werge, Thomas; Westlye, Lars T.; Whiteman, David C.; Zar, Heather J.; Wray, Naomi; Meltzer-Brody, Samantha; Sullivan, Patrick
Publié dans: American Journal of Psychiatry, 2023, ISSN 1535-7228
Éditeur: American Psychiatric Association
DOI: 10.1176/appi.ajp.20230053

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Auteurs: Nguyen, Thuy-Dung; Kowalec, Kaarina; Pasman, Jolle; Larsson, Henrik; Lichtenstein, Paul; Dalman, Christina; Sullivan, Patrick F.; Kuja-Halkola, Ralf; Lu, Yi
Publié dans: Am J Psychiatry, 2023, ISSN 1535-7228
Éditeur: American Psychiatric Association
DOI: 10.17615/axpk-s778

Translational Psychiatry

Auteurs: Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rck; Robert Sigstrm; Lina Jonsson; Caitlin C. Clements; Evelyn Andersson; Julia Boberg; Cathryn M. Lewis; Patrick F. Sullivan; Mikael Landn; Yi Lu
Publié dans: Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023), 2023, ISSN 2158-3188
Éditeur: Springer Nature
DOI: 10.17615/5wts-zz20

Nature Communications

Auteurs: Joeri Meijsen; Kejia Hu; Morten D. Krebs; Georgios Athanasiadis; Sarah Washbrook; Richard Zetterberg; Raquel Nogueira Avelar e Silva; John R. Shorter; Jesper R. Gdin; Jacob Bergstedt; David M. Howard; Weimin Ye; Yi Lu; Unnur A. Valdimarsdttir; Andrs Ingason; Dorte Helenius; Oleguer Plana-Ripoll; John J. McGrath; Nadia Micali; Ole A. Andreassen; Thomas M. Werge; Fang Fang; Alfonso Buil
Publié dans: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024), 2024, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/s41467-024-49507-3

JAMA Psychiatry

Auteurs: Simonsson, O; Mosing, MA; Osika, W; Ullen, F; Larsson, H; Lu, Y; Wesseldijk, LW
Publié dans: JAMA Psychiatry, 2024, ISSN 2168-622X
Éditeur: American Medical Association
DOI: 10.1001/JAMAPSYCHIATRY.2024.0047

Nature Communications

Auteurs: Shuyang Yao; Arvid Harder; Fahimeh Darki; Yu-Wei Chang; Ang Li; Kasra Nikouei; Giovanni Volpe; Johan N Lundström; Jian Zeng; Naomi Wray; Yi Lu; Patrick F Sullivan; Jens Hjerling-Leffler
Publié dans: Nature Communications, 2024, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/s41467-024-55611-1

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Auteurs: Jacob Bergstedt; Jolle A. Pasman; Ziyan Ma; Arvid Harder; Shuyang Yao; Nadine Parker; Jorien L. Treur; Dirk J. A. Smit; Oleksandr Frei; Alexey A. Shadrin; Joeri J. Meijsen; Qing Shen; Sara Hgg; Per Tornvall; Alfonso Buil; Thomas Werge; Jens Hjerling-Leffler; Thomas D. Als; Anders D. Brglum; Cathryn M. Lewis; Andrew M. McIntosh; Unnur A. Valdimarsdttir; Ole A. Andreassen; Patrick F. Sullivan; Yi Lu; Fang Fang
Publié dans: Bergstedt , J , Pasman , J A , Ma , Z , Harder , A , Yao , S , Parker , N , Treur , J L , Smit , D J A , Frei , O , Shadrin , A A , Meijsen , J J , Shen , Q , Hägg , S , Tornvall , P , Buil , A , Werge , T , Hjerling-Leffler , J , Als , T D , Børglum , A D , Lewis , C M , McIntosh , A M , Valdimarsdóttir , U A , Andreassen , O A , Sullivan , P F , Lu , Y & Fang , F 2024 , ' Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease ' , Nature Cardiovascular Research , vol. 3 , no. 6 , pp. 754-769 . https://doi.org/10.1038/s44161-024-00488-y, 2024, ISSN 2731-0590
Éditeur: Springer
DOI: 10.1038/s44161-024-00488-y

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Auteurs: Pasman, Jolle A.; Meijsen, Joeri J.; Haram, Marit; Kowalec, Kaarina; Harder, Arvid; Xiong, Ying; Nguyen, Thuy-Dung; Jangmo, Andreas; Shorter, John R.; Bergstedt, Jacob; Das, Urmi; Zetterberg, Richard; Tate, Ashley; Lichtenstein, Paul; Larsson, Henrik; Odsbu, Ingvild; Werge, Thomas; Reichborn-Kjennerud, Ted; Andreassen, Ole A.; Sullivan, Patrick F.; Buil, Alfonso; Tesli, Martin; Lu, Yi
Publié dans: 2666-7762, 2023, ISSN 2666-7762
Éditeur: Elsevier Ltd
DOI: 10.1016/j.lanepe.2023.100621

COSGAP: COntainerized Statistical Genetics Analysis Pipelines

Auteurs: Bayram Cevdet Akdeniz; Oleksandr Frei; Espen Hagen; Tahir Tekin Filiz; Sandeep Karthikeyan; Joëlle Pasman; Andreas Jangmo; Jacob Bergstedt; John R Shorter; Richard Zetterberg; Joeri Meijsen; Ida Elken Sønderby; Alfonso Buil; Martin Tesli; Yi Lu; Patrick Sullivan; Ole A Andreassen; Eivind Hovig
Publié dans: Bioinformatics Advances, 2024, ISSN 2635-0041
Éditeur: Oxford University Press
DOI: 10.1093/bioadv/vbae067

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Auteurs: Heimer, Hakon; Stefánsson, Hreinn; Van der Eycken, Erik; Lu, Yi; Schubert, Alexander; Sønderby, Ida; Babic, Aleksandar; Koch, Elise; Camacho Collados, José; Werge, Thomas; Walters, James T R; White, Nathan; Molden, Espen; Posthuma, Danielle; Stefánsson, Kári; O'Connell, Kevin S; Sullivan, Patrick F; Dale, Anders M; Milani, Lili; Marshall, Serena E; Angulo, Cecilia; O'Donovan, Michael C; Andreassen, Ole A; Pardiñas, Antonio F; Selvaggi, Pierluigi; Djurovic, Srdjan
Publié dans: Biological Psychiatry, 2024, ISSN 1873-2402
Éditeur: Elsevier Inc
DOI: 10.17615/X74J-R768