Subtype as a key to reduce heterogeneity of treatment effects in major depressive disorder

Informations projet

SUBTREAT

N° de convention de subvention: 101042183

DOI

10.3030/101042183

Date de signature de la CE 2 Mars 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2027

Financé au titre de

• European Research Council (ERC)

Coût total

€ 1 500 000,00

Contribution de l’UE

€ 1 500 000,00

Coordonné par

KAROLINSKA INSTITUTET
Sweden

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (1)

Data Management Plan

Draft data management plan

Publications

Peer reviewed articles (15)

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression

Auteurs: Guintivano, Jerry; Byrne, Enda M.; Kiewa, Jacqueline; Yao, Shuyang; Bauer, Anna E.; Aberg, Karolina A.; Adams, Mark J.; Campbell, Archie; Campbell, Megan L.; Choi, Karmel W.; Corfield, Elizabeth C.; Havdahl, Alexandra; Hucks, Donald; Koen, Nastassja; Lu, Yi; Mægbæk, Merete L.; Mullaert, Jimmy; Peterson, Roseann E.; Raffield, Laura M.; Sallis, Hannah M.; Sealock, Julia M.; Walker, Alicia; Watson, Hunna J.; Xiong, Ying; Yang, Jessica M.K.; Anney, Richard J.L.; Gordon-Smith, Katherine; Hubbard, Leon; Jones, Lisa A.; Mihaescu, Raluca; Nyegaard, Mette; Pardiñas, Antonio F.; Perry, Amy; Saquib, Nazmus; Shadyab, Aladdin H.; Viktorin, Alexander; Andreassen, Ole A.; Bigdeli, Tim B.; Davis, Lea K.; Dennis, Cindy-Lee; Di Florio, Arianna; Dubertret, Caroline; Feng, Yen-Chen A.; Frey, Benicio N.; Grigoriadis, Sophie; Gloaguen, Emilie; Jones, Ian; Kennedy, James L.; Krohn, Holly; Kunovac Kallak, Theodora; Li, Yun; Martin, Nicholas G.; McIntosh, Andrew M.; Milgrom, Jeannette; Munk-Olsen, Trine; Oberlander, Tim; Olsen, Catherine M.; Ramoz, Nicolas; Reichborn-Kjennerud, Ted; Robertson Blackmore, Emma; Rubinow, David; Skalkidou, Alkistis; Smoller, Jordan W.; Stein, Dan J.; Stowe, Zachary N.; Taylor, Valerie; Tebeka, Sarah; Tesli, Martin; Van Lieshout, Ryan J.; van den Oord, Edwin J.C.G.; Vigod, Simone N.; Werge, Thomas; Westlye, Lars T.; Whiteman, David C.; Zar, Heather J.; Wray, Naomi; Meltzer-Brody, Samantha; Sullivan, Patrick
Publié dans: American Journal of Psychiatry, 2023, ISSN 1535-7228
Éditeur: American Psychiatric Association
DOI: 10.1176/appi.ajp.20230053

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Auteurs: Nguyen, Thuy-Dung; Kowalec, Kaarina; Pasman, Jolle; Larsson, Henrik; Lichtenstein, Paul; Dalman, Christina; Sullivan, Patrick F.; Kuja-Halkola, Ralf; Lu, Yi
Publié dans: Am J Psychiatry, 2023, ISSN 1535-7228
Éditeur: American Psychiatric Association
DOI: 10.17615/axpk-s778

Translational Psychiatry

Auteurs: Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rck; Robert Sigstrm; Lina Jonsson; Caitlin C. Clements; Evelyn Andersson; Julia Boberg; Cathryn M. Lewis; Patrick F. Sullivan; Mikael Landn; Yi Lu
Publié dans: Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023), 2023, ISSN 2158-3188
Éditeur: Springer Nature
DOI: 10.17615/5wts-zz20

Nature Communications

Auteurs: Joeri Meijsen; Kejia Hu; Morten D. Krebs; Georgios Athanasiadis; Sarah Washbrook; Richard Zetterberg; Raquel Nogueira Avelar e Silva; John R. Shorter; Jesper R. Gdin; Jacob Bergstedt; David M. Howard; Weimin Ye; Yi Lu; Unnur A. Valdimarsdttir; Andrs Ingason; Dorte Helenius; Oleguer Plana-Ripoll; John J. McGrath; Nadia Micali; Ole A. Andreassen; Thomas M. Werge; Fang Fang; Alfonso Buil
Publié dans: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024), 2024, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/s41467-024-49507-3

JAMA Psychiatry

Auteurs: Simonsson, O; Mosing, MA; Osika, W; Ullen, F; Larsson, H; Lu, Y; Wesseldijk, LW
Publié dans: JAMA Psychiatry, 2024, ISSN 2168-622X
Éditeur: American Medical Association
DOI: 10.1001/JAMAPSYCHIATRY.2024.0047

Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Auteurs: Rück, Christian; Krebs, Kristi; German, Jakob; Andersson, Evelyn; Kowalec, Kaarina; Nguyen, Thuy-Dung; Ganna, Andrea; Lu, Yi; Gong, Tong; Pasman, Joëlle A.; Bäckman, Julia; Karlsson, Robert; Sullivan, Patrick F.; Jermy, Bradley; Lehto, Kelli; Clements, Caitlin C.; Hörbeck, Elin; Jonsson, Lina; Landén, Mikael; Sigström, Robert; Xiong, Ying
Publié dans: Molecular Psychiatry, 2025, ISSN 1476-5578
Éditeur: Springer Nature
DOI: 10.17615/WR0R-WY55

Nature Communications

Auteurs: Shuyang Yao; Arvid Harder; Fahimeh Darki; Yu-Wei Chang; Ang Li; Kasra Nikouei; Giovanni Volpe; Johan N Lundström; Jian Zeng; Naomi Wray; Yi Lu; Patrick F Sullivan; Jens Hjerling-Leffler
Publié dans: Nature Communications, 2024, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/s41467-024-55611-1

The Lancet Psychiatry

Auteurs: Elise Koch; Sophie Elizabeth Smart; Guðmundur Einarsson; Anders Kämpe; Lina Jonsson; Maris Alver; Matthew Henry Iveson; Andreas Göteson; Antonio F Pardiñas; Ida E. Sønderby; Kevin O’Connell; Qingqin Li; Lu Yi; Hreinn Stefansson; Kári Stefánsson; Heather C Whalley; Mikael Landén; Michael C. O’Donovan; Knut T. Smerud; Gerard R. Dawson; Thomas Werge; Alfonso Buil; Andreas Reif; Lili Milani; Espen Molden; Chiara Fabbri; Alessandro Serretti; James Walters; Cathryn Lewis; Ole A. Andreassen
Publié dans: The Lancet Psychiatry, 2025, ISSN 2215-0366
Éditeur: Elsevier
DOI: 10.31234/OSF.IO/KUMEA_V1

Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Auteurs: Jacob Bergstedt; Jolle A. Pasman; Ziyan Ma; Arvid Harder; Shuyang Yao; Nadine Parker; Jorien L. Treur; Dirk J. A. Smit; Oleksandr Frei; Alexey A. Shadrin; Joeri J. Meijsen; Qing Shen; Sara Hgg; Per Tornvall; Alfonso Buil; Thomas Werge; Jens Hjerling-Leffler; Thomas D. Als; Anders D. Brglum; Cathryn M. Lewis; Andrew M. McIntosh; Unnur A. Valdimarsdttir; Ole A. Andreassen; Patrick F. Sullivan; Yi Lu; Fang Fang
Publié dans: Bergstedt , J , Pasman , J A , Ma , Z , Harder , A , Yao , S , Parker , N , Treur , J L , Smit , D J A , Frei , O , Shadrin , A A , Meijsen , J J , Shen , Q , Hägg , S , Tornvall , P , Buil , A , Werge , T , Hjerling-Leffler , J , Als , T D , Børglum , A D , Lewis , C M , McIntosh , A M , Valdimarsdóttir , U A , Andreassen , O A , Sullivan , P F , Lu , Y & Fang , F 2024 , ' Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease ' , Nature Cardiovascular Research , vol. 3 , no. 6 , pp. 754-769 . https://doi.org/10.1038/s44161-024-00488-y, 2024, ISSN 2731-0590
Éditeur: Springer
DOI: 10.1038/s44161-024-00488-y

Sex differences in familial risk and genetic components of suicide attempts: a register-based cohort study in Sweden

Auteurs: D’Onofrio, Brian M; Fang, Fang; Chang, Zheng; Hu, Kejia; Lichtenstein, Paul; Gong, Tong; Kuja-Halkola, Ralf; Butwicka, Agnieszka; Larsson, Henrik; Bulik, Cynthia; Borges, Karen; Crowley, James J; Rück, Christian; Lu, Yi; Brikell, Isabell; Nguyen, Thuy-Dung; Sullivan, Patrick
Publié dans: BMJ Mental Health, 2026, ISSN 2755-9734
Éditeur: BMJ Group
DOI: 10.17615/00ZR-3P52

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Auteurs: Pasman, Jolle A.; Meijsen, Joeri J.; Haram, Marit; Kowalec, Kaarina; Harder, Arvid; Xiong, Ying; Nguyen, Thuy-Dung; Jangmo, Andreas; Shorter, John R.; Bergstedt, Jacob; Das, Urmi; Zetterberg, Richard; Tate, Ashley; Lichtenstein, Paul; Larsson, Henrik; Odsbu, Ingvild; Werge, Thomas; Reichborn-Kjennerud, Ted; Andreassen, Ole A.; Sullivan, Patrick F.; Buil, Alfonso; Tesli, Martin; Lu, Yi
Publié dans: 2666-7762, 2023, ISSN 2666-7762
Éditeur: Elsevier Ltd
DOI: 10.1016/j.lanepe.2023.100621

Risk factors, impact, and healthcare use related to initial suicide attempts: comprehensive analysis of Swedish population

Auteurs: Kejia Hu; Thuy-Dung Nguyen; Karen Borges; Ralf Kuja-Halkola; Agnieszka Butwicka; Isabell Brikell; James J Crowley; Zheng Chang; Brian M D’Onofrio; Henrik Larsson; Paul Lichtenstein; Christian Rück; Cynthia Bulik; Patrick Sullivan; Fang Fang; Yi Lu
Publié dans: BMJ Medicine, 2025, ISSN 2754-0413
Éditeur: BMJ Group
DOI: 10.17615/A142-2R59

COSGAP: COntainerized Statistical Genetics Analysis Pipelines

Auteurs: Bayram Cevdet Akdeniz; Oleksandr Frei; Espen Hagen; Tahir Tekin Filiz; Sandeep Karthikeyan; Joëlle Pasman; Andreas Jangmo; Jacob Bergstedt; John R Shorter; Richard Zetterberg; Joeri Meijsen; Ida Elken Sønderby; Alfonso Buil; Martin Tesli; Yi Lu; Patrick Sullivan; Ole A Andreassen; Eivind Hovig
Publié dans: Bioinformatics Advances, 2024, ISSN 2635-0041
Éditeur: Oxford University Press
DOI: 10.1093/bioadv/vbae067

An encompassing Mendelian randomization study of the causes and consequences of major depressive disorder

Auteurs: Joëlle A. Pasman; Jacob Bergstedt; Arvid Harder; Tong Gong; Ying Xiong; Sara Hägg; Fang Fang; Jorien L. Treur; Karmel W. Choi; Patrick F. Sullivan; Yi Lu
Publié dans: Nature Mental Health, 2025, ISSN 2731-6076
Éditeur: Springer Nature
DOI: 10.1038/S44220-025-00471-X

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Auteurs: Heimer, Hakon; Stefánsson, Hreinn; Van der Eycken, Erik; Lu, Yi; Schubert, Alexander; Sønderby, Ida; Babic, Aleksandar; Koch, Elise; Camacho Collados, José; Werge, Thomas; Walters, James T R; White, Nathan; Molden, Espen; Posthuma, Danielle; Stefánsson, Kári; O'Connell, Kevin S; Sullivan, Patrick F; Dale, Anders M; Milani, Lili; Marshall, Serena E; Angulo, Cecilia; O'Donovan, Michael C; Andreassen, Ole A; Pardiñas, Antonio F; Selvaggi, Pierluigi; Djurovic, Srdjan
Publié dans: Biological Psychiatry, 2024, ISSN 1873-2402
Éditeur: Elsevier Inc
DOI: 10.17615/X74J-R768