Opioids and insulin secretion: a new avenue to fight type 2 diabetes

Project Information

OpiO

Grant agreement ID: 101043671

DOI

10.3030/101043671

EC signature date 8 June 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 997 915,00

EU contribution

€ 1 997 915,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of Data Management plan

Publications

Peer reviewed articles (12)

Diabetes

Author(s): Maurin L.; Marselli L.; Boissel M.; Ning L.; Boutry R.; Fernandes J.; Suleiman M.; De Luca C.; Leloire A.; Pascat V.; Toussaint B.; Amanzougarene S.; Derhourhi M.; Jorns A.; Lenzen S.; Pattou F.; Kerr-Conte J.; Canouil M.; Marchetti P.; Bonnefond A.; Froguel P.; Khamis A.
Published in: Diabetes, 2024, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/DB24-0215

Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas

Author(s): Sarah Meulebrouck; Victoria Scherrer; Raphaël Boutry; Bénédicte Toussaint; Emmanuel Vaillant; Aurélie Dechaume; Hélène Loiselle; Beverley Balkau; Guillaume Charpentier; Sylvia Franc; Michel Marre; Morgane Baron; Martine Vaxillaire; Mehdi Derhourhi; Mathilde Boissel; Philippe Froguel; Amélie Bonnefond
Published in: Diabetologia, 2023, ISSN 1432-0428
Publisher: Elsevier
DOI: 10.1007/s00125-023-06035-x

The discovery of human agouti-induced obesity and its implication for genetic diagnosis

Author(s): Philippe Froguel; Amélie Bonnefond
Published in: Nature Metabolism, 2022, ISSN 2522-5812
Publisher: Nature Publishing Group
DOI: 10.1038/s42255-022-00695-6

Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study

Author(s): Folon, Lise; Baron, Morgane; Toussaint, Bénédicte; Vaillant, Emmanuel; Boissel, Mathilde; Scherrer, Victoria; Loiselle, Hélène; Leloire, Audrey; Badreddine, Alaa; Balkau, Beverley J.; Charpentier, Guillaume; Franc, Sylvia; Marre, Michel; Aboulouard, Soulaimane; Salzet, Michel; Canouil, Mickaël; Derhourhi, Mehdi; Froguel, Philippe; Bonnefond, Amélie
Published in: The Lancet Diabetes & Endocrinology, 2023, ISSN 2213-8595
Publisher: Elsevier
DOI: 10.1016/S2213-8587(22)00392-8

Monogenic diabetes

Author(s): Amélie Bonnefond; Ranjit Unnikrishnan; Alessandro Doria; Martine Vaxillaire; Rohit N. Kulkarni; Viswanathan Mohan; Vincenzo Trischitta; Philippe Froguel
Published in: Nature Reviews Disease Primers, 2023, ISSN 2056-676X
Publisher: Nature Publishing Group
DOI: 10.1038/s41572-023-00421-w

Pathogenic, total loss-of-function DYRK1B variants cause monogenic obesity associated with type 2 diabetes

Author(s): Lise Folon; Morgane Baron; Victoria Scherrer; Bénédicte Toussaint; Emmanuel Vaillant; Hélène Loiselle; Aurélie Dechaume; Frédérique De Pooter; Raphaël Boutry; Mathilde Boissel; Aboubacar Diallo; Lijiao Ning; Beverley Balkau; Guillaume Charpentier; Sylvia Franc; Michel Marre; Mehdi Derhourhi; Philippe Froguel; Amélie Bonnefond
Published in: Diabetes Care, 2024, ISSN 1935-5548
Publisher: American Diabetes Association
DOI: 10.2337/figshare.24840426

European Journal of Endocrinology

Author(s): Blandine Gatta-Cherifi; Alexandre Laboye; Caroline Gronnier; Maud Monsaingeon-Henry; Sarah Meulebrouck; Morgane Baron; Françoise Bertin; Emilie Pupier; Sophie Cambos; Christine Poitou; Johanne Le Beyec-Le Bihan; Amélie Bonnefond
Published in: European Journal of Endocrinology, 2023, ISSN 0804-4643
Publisher: BioScientifica Ltd.
DOI: 10.1093/EJENDO/LVAD132

Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use

Author(s): Lauriane Le Collen; Brigitte Delemer; Christine Poitou; Martine Vaxillaire; Bénédicte Toussaint; Aurélie Dechaume; Alaa Badreddine; Mathilde Boissel; Mehdi Derhourhi; Karine Clément; Jean M. Petit; Frédéric Tran Mau-Them; Ange-Line Bruel; Christel Thauvin-Robinet; Alexandru Saveanu; Blandine Gatta Cherifi; Johanne Le Beyec-Le Bihan; Philippe Froguel; Amélie Bonnefond
Published in: Genetics in Medicine, 2023, ISSN 1530-0366
Publisher: Nature Publishing Group
DOI: 10.1016/j.gim.2023.100857

Diabetologia

Author(s): Bonnefond, Amélie
Published in: Diabetologia, 2022, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-022-05825-z

Nature Communications

Author(s): Sarah Meulebrouck; Judith Merrheim; Gurvan Queniat; Cyril Bourouh; Mehdi Derhourhi; Mathilde Boissel; Xiaoyan Yi; Alaa Badreddine; Raphaël Boutry; Audrey Leloire; Bénédicte Toussaint; Souhila Amanzougarene; Emmanuel Vaillant; Emmanuelle Durand; Hélène Loiselle; Marlène Huyvaert; Aurélie Dechaume; Victoria Scherrer; Piero Marchetti; Beverley Balkau; Guillaume Charpentier; Sylvia Franc; Michel Marre; Ronan Roussel; Raphaël Scharfmann; Miriam Cnop; Mickaël Canouil; Morgane Baron; Philippe Froguel; Amélie Bonnefond
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51004-6

Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD

Author(s): Manuel Johanns; Joel T. Haas; Violetta Raverdy; Jimmy Vandel; Julie Chevalier-Dubois; Loic Guille; Bruno Derudas; Benjamin Legendre; Robert Caiazzo; Helene Verkindt; Viviane Gnemmi; Emmanuelle Leteurtre; Mehdi Derhourhi; Amélie Bonnefond; Philippe Froguel; Jérôme Eeckhoute; Guillaume Lassailly; Philippe Mathurin; François Pattou; Bart Staels; Philippe Lefebvre
Published in: JHEP Reports, 2024, ISSN 2589-5559
Publisher: Elsevier
DOI: 10.1016/j.jhepr.2023.100948

Trends in Endocrinology and Metabolism

Author(s): Lauriane Le Collen; Philippe Froguel; Amélie Bonnefond
Published in: Trends Endocrinol Metab, 2024, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2024.06.006